Cannabiscientia SA

The entry of cannabis and cannabinoids into the heavily regulated channels of standardised modern medicine is still in its early stages globally. Only a select few cannabinoid products are currently approved for the treatment of a limited number of conditions, though off-label use is widespread. The main challenge in getting a medicine approved is managing to get it to successful completion of all the stages of clinical trials. Difficulties in establishing intellectual property (IP) around cannabinoid treatments are holding back new research and development. Co-authored in collaboration with Cannabiscientia SA, this report gives a clear and detailed account of all activity involving cannabis and cannabinoids in the landscape of pharmaceutical medicine, at a global level. The main topics covered include an analysis of the relevant landscape in clinical trials, patents and innovation. Prohibition Partners Jazz Pharmaceuticals GW Pharmaceuticals plc University of Colorado Yale University University of Florida NYU Langone Health University Health Network University of California, San Diego - Rady School of Management

New Study on Cannabis-Based Medicinal Products (CBMPs) and Suicidal Ideation   A recent study analyzed the impact of Cannabis-Based Medicinal Products (CBMPs) on suicidal ideation (SI) among individuals with chronic conditions using CBMPs.   The study revealed that, at the start, 25% of participants reported experiencing SI. Those with SI showed higher levels of depression, poorer general health, and lower quality of life compared to those without SI. Specifically, the SI group had a mean depressed mood score of 17.4 versus 11.3 in the non-SI group, disturbed sleep scores of 13.8 versus 12.2, general health scores of 43.6 versus 52.2, and quality of life scores of 0.44 versus 0.56.   The study tracked participants over time and found positive trends. At the 3-month follow-up, SI prevalence decreased from 23.6% to 17.6%. At the 12-month follow-up, there was a significant reduction in depressed mood, especially among those with SI, with their scores dropping from a baseline mean of 17.7 to 10.3. For other patients, the scores decreased from a baseline mean of 11.1 to 7.0.   In conclusion, CBMPs show promise in reducing both the prevalence and intensity of suicidal ideation, offering a potential therapeutic benefit for individuals dealing with chronic conditions and associated mental health challenges. Yours in Science, Cannabiscientia SA   #MedicalCannabis #QoL #Suicidal  

Cannabis and Multiple Sclerosis: analysis of major clinical studies Are you interested in learning about the latest research on cannabis and its potential benefits for Multiple Sclerosis (MS)? Join Cannabiscientia SA for an enlightening session where we'll be reading an excerpt from Principles of Clinical Cannabinology focusing on "Cannabis and Multiple Sclerosis". In this session, we will explore MS and its impact on the nervous system, discuss current pharmacological remedies and their limitations, and explore the promising role of cannabis in managing MS symptoms, particularly spasticity. We will also review key findings from major clinical studies on the use of cannabis in MS treatment and examine the side effects and safety considerations of cannabinoid preparations. This is a must-attend for anyone interested in the role of cannabis in neuroinflammatory diseases. Whether you're a healthcare professional, a researcher, or someone affected by MS, this session will provide valuable insights. Take advantage of this opportunity to expand your knowledge and engage in a live discussion on this important topic! We are looking forward to seeing you there! #MultipleSclerosis #Cannabinoid #MedicalCannabis

CBD for glioma   In our last LinkedIn lesson, we deepen the role of cannabis and cannabinoids in treating gliomas and glioblastomas, by reading an excerpt taken from Cannabiscientia’s handbook “Principles of Clinical Cannabinology” (you can find the lesson here: https://lnkd.in/eZbiNu5q) To corroborate what we discussed, a recent review published in the Journal of Translational Medicine has explored the therapeutic potential of cannabidiol (CBD) in glioma treatment.   Highlighting CBD's anti-tumoral, anti-inflammatory, and neuroprotective properties, the review delves into preclinical and clinical research, including the efficacy of CBD in inhibiting glioma cell proliferation, inducing apoptosis, and enhancing the effects of traditional therapies. It also discusses the role of nanomedicine in improving CBD delivery.   Despite challenges, CBD shows promise as a novel treatment for glioma, with ongoing research needed to address current limitations.   Yours in Science, Cannabiscientia SA #CBD #Glioma #Nanomedicine

Exploring Cannabinoids for Glioblastoma Join us for our next LinkedIn session where we'll read an excerpt from Cannabiscientia's comprehensive handbook, "Principles of Clinical Cannabinology," which analyzes the recent study on the efficacy and safety of nabiximols in patients with glioblastoma. Glioblastoma, or glioblastoma multiforme (GBM), is among the most common and aggressive brain tumors, predominantly affecting adults. Despite various treatments, effective therapies to combat glioblastoma are still lacking, and the average survival rate remains dismally low. In this session, we'll explore the potential of nabiximols, a nasal spray containing cannabinoids (THC and CBD in a 1:1 ratio), which has shown promise in recent studies. Don't miss this chance to gain valuable insights and stay informed about the evolving landscape of cannabis in oncology. See you there! #Glioblastoma #Oncology #MedicalCannabis

Exploring the Anti-inflammatory Potential of Fermented Hemp Seeds   A recent study has uncovered the significant anti-inflammatory potential of Cannabis sativa L. (hemp) seeds fermented with Lactiplantibacillus plantarum. This research highlights how fermentation can enhance the natural anti-inflammatory properties of hemp seeds, making them a promising food source for managing inflammation-associated disorders.   The study examined the effects of fermenting hemp seeds with 10 different probiotic strains, finding that those fermented with Lactiplantibacillus plantarum (FHS) showed the most notable anti-inflammatory activity. The fermented hemp seeds demonstrated a reduction in the expression of critical inflammatory markers such as TLR4, NF-κBp65, and iNOS. Additionally, there was a dose-dependent inhibition of inflammatory cytokines TNF-α, IL-6, IL-1β, and NO within a concentration range of 50 to 500 µg/mL.   Metabolomics analysis revealed significant metabolic changes in the fermented seeds, identifying indolelactic acid (IA) and homovanillic acid (HVA) as the primary anti-inflammatory metabolites. These compounds exhibited lower IC50 values for inhibiting TNF-α, IL-1β, IL-6, IL-18, and NO, confirming their potent anti-inflammatory abilities. The study also validated the uptake and bioaccessibility of these metabolites, further affirming their potential benefits.   This research opens the door to developing novel hemp seed-based products to mitigate inflammation and improve health outcomes.   Yours in Science, Cannabiscientia SA   #Inflammation #HempSeeds #Probiotics   https://lnkd.in/dfevwseN.

Thank you Cannabis Health for citing Principle of Clinical Cannabinology and co-authors Viola Brugnatelli and Fabio Turco in this article on #alzheimer's

Join us for an insightful session on the age-old use of cannabis in medicine, focusing on the endocannabinoid system's role in pain management. Discover the history of cannabis and its potential to treat chronic pain, mood disturbances, and sleep issues. Learn about the current clinical evidence supporting the use of cannabis and its active components, THC and CBD, in pain therapy. Get practical insights into how cannabis is applied in pain management, including modern delivery methods beyond inhalation. Understand why ongoing education and training for healthcare professionals are crucial in this evolving field. We will read an excerpt from the first edition of Cannabiscientia's handbook, "Principles of Clinical Cannabinology." Explore how endocannabinoids interact with our nervous system to modulate pain. Exciting News: The second edition of "Principles of Clinical Cannabinology" is now available for pre-order here: https://lnkd.in/ezhAUd_U When: Next Tuesday, July 9th Time: 5.30 PM CET #EndocannabinoidSystem #PainManagement #ClinicalCannabinology

Exploring the Endocannabinoid System's Role in Depression and Treatment Response   Recent research has further analyzed the role of the #endocannabinoid system (ECS) in #depression and suicidality.   A study involving 17 patients with severe major depression undergoing #electroconvulsive therapy (ECT) identified changes in plasma endocannabinoid levels and their correlation with depressive symptoms.   Findings showed significant increases in endocannabinoid concentrations after six and twelve ECT sessions, with notable correlations between these levels and symptoms of depression, #anxiety, and suicidality. One specific endocannabinoid, l-Gly, distinguished between remitted and non-remitted patients during therapy.   This research suggests that ECS imbalance is linked to depression and can be modulated by ECT, positioning plasma endocannabinoids as potential biomarkers for depression treatment response.   Yours in Science, Cannabiscientia SA

Discover the millennia-old use of cannabis in oncology, supported by intriguing historical anecdotes. Understand the potential of phytocannabinoids in alleviating symptoms like nausea, appetite loss, pain, mood disturbances, and sleep issues in cancer patients. Explore the current state of clinical evidence supporting the use of cannabis and its active components, THC and CBD, in cancer therapy. Gain practical insights into the application of cannabis in palliative care, including modern delivery methods beyond inhalation. Learn why ongoing education and training for healthcare professionals are essential in this field. 🍀 Join us next Tuesday for our weekly appointment! 🍀🍀 Discover more in our handbook Principles of Clinical Cannabinology: https://lnkd.in/ezhAUd_U #Cannabis #PalliativeCare #Oncology #MedicalCannabis #Cannabinoids #CancerTherapy