Jobst Technologies GmbH - an IST AG company

The 33rd Annual Meeting of the Deutsche Transplantationsgesellschaft e.V. is in full swing – we are looking forward to meet you at our booth! 🤝 Thanks to the committee and the DTG the event is packed with latest results on success factors and current challenges of the clinical reality in organ transplantation. Both state of the art as well as novel approaches including hypothermic and normothermic transplantation are discussed and presented. Our team will be on-site to present our innovative biosensor solutions aimed at improving the quality of life for transplant patients. We warmly invite all attendees to visit our booth and learn more about the features and advantages of our biosensors for continuous metabolic monitoring in organ care applications! In addition, we will be exhibiting at COMPAMED MEDICA in Düsseldorf next week. This fair, taking place from November 11 to 14, 2024, is one of the world’s leading events for the medical technology industry. We look forward to showcasing our biosensor portfolio to an international audience there as well. We look forward to inspiring 💡 conversations and exchanges with leading experts and colleagues from around the world! #JobstTechnologies #DTG2024 #COMPAMEDMEDICA2024 #TransplantationMedicine #Innovation #Research #compamed #glucose #biosensor #lactate #IVAM #organcare

🔔 Join Us at COMPAMED! We’re thrilled to host a unique, hands-on session in microfluidics at COMPAMED, alongside the IVAM Microtechnology Network! Get ready to Build Your Own Microfluidic Setup and dive into the latest microfluidic innovations with live demonstrations from top industry players: 🌟 Bartels Mikrotechnik 🌟 Disc Pumps | The Lee Company 🌟 microfluidic ChipShop GmbH 🌟 memetis GmbH 🌟 Jobst Technologies GmbH - an IST AG company 🌟 Fluigent Discover components from top suppliers like Sensirion, Honeywell, Festo, Staiger GmbH & Co. KG, and many more! 🗓️ Date: 12.11.2024 ⏰ Time: 05:10 pm CET 📍 Location: COMPAMED High-Tech Forum, Hall 8a - G40 Register here: https://lnkd.in/emhy7bUr #LabonaChip #microfluidics #IVAM #COMPAMED2024 #Innovation #HighTechForum #IVAMNetwork #Networking #Microtechnology

🔬 Proudly presenting the UNLOOC consortium partners, boasting an extensive network of 51 organisations from 10 countries! In the coming months we will introduce each partner and the related use cases - all making groundbreaking research in the area of organ-on-chips. 🔬The UNLOOC project is coordinated by microfluidic ChipShop GmbH from Germany. An innovation consulting company Spinverse from Finland provides the consortium with administrative services. 🔬 This project is supported by the Chips Joint Undertaking (Grant Agreement No. 101140192) and its members including the top-up funding of Belgium, Germany, Hungary, Ireland, Italy, the Netherlands, Portugal, Romania and Spain. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI). 🤩 Stay tuned for our posts on this channel! #UNLOOCChipsJU #unlooc #OrganOnChip #consortium #FutureOfMedicine #EUresearch

Biosensor application in bioprocessing: 💡what are your thoughts?💡 Over the past weeks we dived into different possibilities on how to integrate enzyme-based sensors for measuring and monitoring Glucose, Lactate, Glutamine, and Glutamate levels in bioprocessing 🎯 . The considerations we tackled were   1.      Ensuring sterility with microdialysis probes 2.      Gamma-Irradiated glucose biosensors as in-line sensors 3.      Automated sterile sampling and media extraction 💬 We want to hear from you! What did we miss? What do you see as the key requirements for next-generation online process analytical tools? Share your thoughts in the comments below! 👇 #biosensors #continuous #glucose #lactate #glutamine #glutamate #sterile #bioprocessing #PAT #BioProcessInternational #BPIConf

📢Continuous PAT in Bioprocessing 3: Sterile Sampling Sterile sampling kits and sterile sampling probes are widely used for safe and ⚡contamination-free medium extraction⚡ in bioprocesses. This provides real-time information, assists the improvement of the overall efficiency of the bioprocess and generates data for AI-based models. Sterile sampling can be facilitated by either pulling out sample through sterile filter membranes, check valves, septum-based solutions or sterile connector systems and further. Repeatable-use sterile sampling probes offer the highest degree of automation and can thus interface sensor components that automatically provide valuable data with short intervals between sample draw-outs and even continuous flow read-out. Contamination-free repeatable-use sampling: ⁉Sterile sampling probes ensure the sterility of closed cultivation systems by employing either micro filter membranes or probe-tip mounted check valves. After extraction through these filters or valves, reactor medium sample is pulled out and analyzed outside immediately of the bioreactor. Further options for continuous, repeatable-use sampling present themselves by separating the fluidic line of an extraction port with a peristaltic pump roller, by a check-valve or a combination of both. Additional measures to ensure the safety of the reactor can encompass sterile air flushing, introduction of cleaning agents, localized heating or UV-irradiation for automated sanitation. Our enzymatic-based biosensor components can be directly interfaced with the outlet of such probes, giving immediate readings of Glucose, Lactate, Glutamine (and others) right at the point of exit without any time delay or manual handling required 🎯. 👉Real-Time Adjustments to target optimal culture conditions: Repeated, automated monitoring allows for real-time adjustments to be made, ensuring that the bioprocess remains within desired parameters range. Having dedicated biosensor components interfacing a reactor provides the opportunity for frequent automated sampling and analysis. With direct measurement at the reactor site a hands-off approach is facilitated, allowing for scalable application with minimal geometrical footprint, and the capability to automate reactor oversight and control minute by minute 24h per day, 7 d a week. 👉Components for automated at-line monitoring Jobst Technologies provides enzyme-based biosensors suitable for at-line monitoring of Glucose, Lactate, Glutamine, Glutamate, and others✅. Our small flow through cells can cope with ultra-low sample volume and provide long-term robust operation. Jobst Technologies’ biosensors operate directly with (even cell-containing) cultivation medium without any sample preparation required. 🤝 Meet us: For more information visit us at booth 1729 at the BioProcess International 2024 in Boston and reach out via eMail at info.jobst@ist-ag.com. #biosensors #continuous #glucose #lactate #glutamine #sterile #bioprocessing #PAT

📢 Continuous PAT in Bioprocessing 2: Gamma-Irradiated Glucose Biosensors Gamma-irradiated glucose biosensors offer ⚡inline metabolic monitoring⚡ in bioprocessing. Without any additional fluid handling needed, the sensor components can continuously measure glucose levels. This provides critical data for continuous metabolic monitoring and even closed-loop control systems for targeted glucose levels with hands-free operation during the whole cultivation cycle. Robust and Reliable Monitoring: ⁉ Our glucose biosensor is capable to withstand gamma irradiation, ensuring it remains functional and reliable in demanding bioprocess environments. This robustness is crucial for maintaining continuous and accurate monitoring in the application. By using our proprietary “xx-range” membrane configuration multiple weeks of continuous operation directly in contact with the medium can be achieved 🎯. 👉 Optimizing Feed Strategies: With real-time data on glucose levels, bioprocess engineers can design and monitor optimized growth, production, transfection conditions and any additional strategy and process model where glucose is a relevant input to ✅. Continuous in-line monitoring with gamma irradiated glucose sensors thus can lead to improved process efficiency and control as well as product quality and safety without any hands-on time for sensor handling.  Cost and labor effective solutions for continuous automated PAT will be of paramount interest not only in traditional biomanufacturing, and even more in Cell and Gene Therapy manufacturing and other Advanced Therapeutics production.  Furthermore, via advanced feeding algorithms and AI models, this data can play the key role in optimizing conditions for cultivations. This offers potential for more consistent, higher quality and cost-effective products in upstream bioprocessing 🥉 . 👉 Components for continuous in-line glucose monitoring: Jobst Technologies provides enzymatic-based biosensor components suitable for gamma irradiation in various form factors, ready to be integrated in PG13.5 threaded reactor probes, flow through cells for perfusion and fed-batch reactors, micro-probes for single use bag applications and more. If you are an automation provider for bioprocess technology equipment, or a R&D lab looking for additional PAT tools don’t hesitate to reach out to us! 🤝 Meet us: For more information visit us at booth 1729 at the BioProcess International 2024 in Boston and reach out via eMail at info.jobst@ist-ag.com. #biosensors #continuous #glucose #lactate #glutamine #glutamate #sterile #bioprocessing #PAT #BioProcessInternational #BPIConf

📢 Continuous PAT in Bioprocessing 1: Enhancing sterility security with Microdialysis Probes In bioprocess technology, ⚡ maintaining sterility is crucial⚡ . One effective solution to generate online readings of metabolic conditions is the use of microdialysis probes that can withstand autoclaving. These probes can be pre-mounted in single-use bags, T-flasks or smaller scale disposable reactors via LUER Lock ports and other mounting configurations. ⁉ During operation, a continuous stream of transport fluid in the single µl/min range flows through the probe. It passes a semi-permeable membrane that allows small molecules (like metabolites) from the surrounding reactor medium to diffuse into the transport fluid but poses a tight barrier for microbial contaminations. The fluid, now containing the diffused molecules representing the concentrations in the reactor closely, is leaving the probe on the outlet and analyzed in real-time with our flow-through biosensor components. 👉 Continuous Monitoring for Consistent Data Microdialysis probes provide a reliable method for continuous monitoring of critical parameters like glucose, lactate as well as glutamine concentrations, and others. Furthermore, via advanced feeding algorithms and AI models, this data can play the key role in optimizing conditions for cultivations. Cost Savings and Efficiency By enabling precise control over nutrient feed, these probes help in reducing the amount of feed or perfusion medium required. The automated operation of continuous online monitoring via microdialysis probes greatly reduces hands-on time of the operators and is not consuming precious process medium. 👉Enhanced Product Quality and Safety The application of continuous biosensors for PAT with microdialysis probes generates valuable data in single-use bags, (very) small-to medium reactor sizes up to large scale production and perfusion reactors. The ability to monitor and adjust conditions in real-time ensures that the final product meets high-quality standards and supports GMP requirements on quality and safety of the process. Especially in CGT and ATMP metabolic fingerprinting of the production process offers traceability, comparability and contributes to predictability of treatment success. 🎯 👉Components for online PAT Jobst Technologies from Freiburg, Germany, and have joined forces with a commercial manufacturer of LUER-connector integrated microdialysis probes in providing the crucial components for such a monitoring system✅. If you are a provider for bioprocess technology equipment or a R&D lab looking for additional PAT tools don’t hesitate to reach out to us to obtain sample components! For more information visit us at booth 1729 at the BioProcess International 2024 in Boston and reach out via eMail at info.jobst@ist-ag.com 🤝. #biosensors #continuous #glucose #lactate #glutamine #glutamate #sterile #bioprocessing #PAT #BioProcessInternational #BPIConf

🚀 Continuous PAT in Bioprocessing 👉 Are you looking to enhance the efficiency of your bioprocesses? Curious about how continuous monitoring of cell metabolism can save costs and improve product quality? 📣 In our upcoming LinkedIn posts, we delve into three application scenarios for biosensors in bioprocess technology. At Jobst Technologies, we specialize in continuous biosensors for glucose, lactate, glutamine, glutamate and more, providing cutting-edge solutions for plug-and-play continuous monitoring in bioprocess environments. ⚡ Our products ensure high accuracy and robust reliability even under challenging conditions ⚡. Process Analytical Technologies (PAT) play a crucial role in modern bioprocessing by enabling monitoring and even control of critical process parameters. PAT tools, such as our advanced biosensor components, provide valuable insights into the cultivation process. This opens the door for improved process efficiency, reduced variability, and enhanced quality of the therapeutic product 🎯. Join us as we explore the application of our sensors not only to enable continuous PAT analysis, but also to ensure sterility and safety of the reactor ✅. Stay tuned to find out how these technologies can revolutionize your bioprocessing operations! For more information visit us from Sept. 23rd – 26th 2024 at booth 1729 at BioProcess International 2024 in Boston, USA and reach out via eMail at info.jobst@ist-ag.com 🤝.   #biosensors #continuous #glucose #lactate #glutamine #glutamate #sterile #bioprocessing #PAT #online #BPI #BioProcessInternational #CellandGeneTherapyInternational #BPIConf

📢 Second Generation PAT4CGT Prototype Shipped to Stemmatters!! 🔗 Collaboratively developed by expert teams at Jobst Technologies GmbH - an IST AG company,  Limula and Bioprocess Technology at TU Wien, our second generation prototype marks a significant step forward. 💡 It features improved ergonomics, enhanced casing to protect internal components, a sampling port with longer tubing, improved software and graphic interface. ⬇ Learn more

📢 This week, Stemmatters had the pleasure of hosting the esteemed partners from the PAT4CGT Project for an in-person General Assembly and the completion of the technology transfer of the project’s prototype to Stemmatters. We were thrilled to be joined by representatives from Limula, Jobst Technologies GmbH - an IST AG company, Technische Universität Wien, Exothera , Da Vinci Labs, and Crowdhelix. Together, we discussed the progress and next steps of our innovative project as we pass the halfway point of the project. 🚀 We're excited to announce that the PAT4CGT prototype is now up and running at Stemmatters, ready to identify and monitor critical process parameters (CPPs) for cell and gene manufacturing processes. A big thank you to all of our project partners for such a productive visit! We look forward to our continued collaboration in the next stage of this groundbreaking project. #innovation #pat4cgt #collaboration #cellgenetherapy #celltherapy #genetherapy #CGTmanufacturing