Depixus

Depixus MAGNA One is available now for early adopters! Be among the first to explore the potential of this breakthrough technology, offering insights into biomolecular interactions like never before. Our new website is live and packed with everything you need to explore Depixus MAGNA One's potential, including: - An introduction to Depixus MAGNA One and how it enables real-time analysis of thousands of individual biomolecular interactions. - Applications across biological research and drug discovery, from uncovering disease mechanisms to exploring challenging targets such as protein-protein interactions and RNA. - Access to publications, app notes, brochures, and other resources to discover how MAGNA One can accelerate your research. - Details on how to contact us and bring our award-winning platform into your lab. Ready to dive deeper? Visit depixus.com to learn more.

Depixus MAGNA One is here! Discover what it can do for your research. Launched on October 1st, our award-winning magnetic force spectroscopy instrument offers vivid, real-time views of individual biomolecular interactions at scale. Most analytical techniques rely on averages to yield information about biomolecular interactions—but your research is far from average. Depixus MAGNA One allows you to: 🧬 Understand how molecular heterogeneity affects biological processes 👀 Observe changes in molecular conformations and interactions as they happen 🔍 Spot rare interactions with crucial effects on biology and therapeutics With simplified sample prep, flexible software tools, and rich data detail, there’s no need to settle for bulk or surrogate measurements. Instead, Depixus MAGNA One reveals thousands of individual binding events at once, giving you unprecedented kinetic, structural, and functional insights. With Depixus MAGNA One you get: 🚀 Confident lead selection even for challenging drug targets such as RNA and protein-protein interactions 🔬 In-depth understanding of molecular interactions 💻 A user-friendly tool that makes magnetic force spectroscopy accessible Explore Depixus MAGNA One now — download the brochure for more information: https://lnkd.in/erjiUJxt #MolecularBiology #biotech #biophysics #DrugDiscovery #DrugDevelopment

Last week, we officially launched Depixus MAGNA One at Discovery on Target in Boston! We’re incredibly proud of launching the world’s first commercial technology for exploring single molecule interactomics at scale. In the photo below, Pascale Beurdeley (Fehlbaum), Senior VP of Product Development, demonstrates the power of Depixus MAGNA One, showcasing its ability to analyze complex interactions between diverse biomolecules such as RNA, proteins, and small molecules in real-time. 🔬✨ Depixus MAGNA One is available now. Find out how it can power your research here: https://lnkd.in/eBJHyRpx

*TODAY 12pm EST/5pm BST/6pm EST* Our free webinar with the Biophysical Society is your chance to meet Depixus MAGNA One - the first instrument for real-time analysis of biomolecular interactions at scale https://lnkd.in/gzq-v2kx #biophysics #interactomics #drugdevelopment

Did you hear? Earlier this week we launched Depixus MAGNA One! As part of our launch, we’re thrilled to announce an exclusive webinar in partnership with the Biophysical Society! 📅 Date: October 9, 2024 ⏰ Time: 12:00 PM - 1:00 PM EST 🎤 Hosted by: Gordon Hamilton, CEO of Depixus Depixus MAGNA One is the world’s first large-scale magnetic force spectroscopy platform. It allows you to see biology as it really happens—offering unprecedented real-time insights into thousands of biomolecular interactions simultaneously. Our game-changing laboratory instrument can analyze individual and multi-way interactions between DNA, RNA, proteins and small molecules, including challenging targets such as RNA and protein-protein interactions. Whether you're exploring fundamental biological mechanisms or developing novel therapeutics, don’t miss this chance to explore how Depixus MAGNA One can transform your research. 👉 Register for the webinar here: https://lnkd.in/gzq-v2kx 👈 #Biophysics #DrugDiscovery #Interactomics #DrugDevelopment #Webinar 

We are thrilled to announce the official launch of Depixus MAGNA One, the world’s first laboratory instrument for analyzing individual biomolecular interactions at scale! 🎉 Depixus MAGNA One enables researchers to explore complex biological interactions with unprecedented detail and ease. From DNA, RNA, proteins, and more, it offers real-time insights into the molecular mechanisms driving disease, accelerating drug discovery and development. 🔬💡 🌟 Key features: - Real-time measurement of thousands of individual interactions - Probe the energetics of complex multi-way interactions across a wide range of affinities - Generate detailed kinetic and thermodynamic data  - Improved confidence in lead selection, especially for hard-to-drug targets Learn more in our official press release: https://lnkd.in/eBJHyRpx #RNATherapeutics #DrugDiscovery #Biotech #Interactomics #ProteinBinding #ProteinInteractions

🎉 New paper out now in Nature Communications! In a recently published study, RNA-targeted drug discovery expert John (Jay) Schneekloth used Depixus’ Magnetic Force Spectroscopy (MFS) technology to investigate how synthetic ligands can flip the PreQ1 bacterial riboswitch. Riboswitches are structured RNA sequences that change conformation when bound by a ligand, helping to control metabolic pathways by altering gene expression. Using Depixus’ MFS platform, Schneekloth and colleagues confirmed that their novel synthetic ligand binds to and stabilizes the RNA structure of the PreQ1 riboswitch. Whereas binding by the natural PreQ1 ligand induces a stable folded structure, the synthetic ligand instead stabilizes a partially folded state via a kinetic mechanism—a distinction other measurement techniques could not make. 🧬 The result: a synthetic ligand that effectively modulates gene activity. Depixus’ MFS platform’s ability to shed light on molecular interactions in biologically relevant settings made it essential to this work—and makes it a valuable tool for lead selection in the development of novel therapeutics. 🚨 To learn more about this study, read the press release now: https://lnkd.in/egKcCZgH #DrugDiscovery #DrugDevelopment #RNAtherapeutics #biotech

When it comes to understanding biomolecular interactions, having a comprehensive view is crucial. With our magnetic force spectroscopy (MFS) platform, you can get both kinetic and thermodynamic data on a single instrument and in a single experiment with minimal starting material. With our MFS platform, you can: 🔬 Get direct read-outs of association and dissociation rates (kon & koff) without relying on surrogate measurements. ⏱ Monitor the impact of ligand binding, and capture dynamic measurements in real time. 🌡️ Measure the energy of interactions, including entropy, enthalpy, and DeltaG, for a full understanding of the forces at play. 🔎 Reveal biological variability in stunning detail by repeated analysis of thousands of individual interactions By combining these insights, our MFS platform provides a deeper understanding of how molecules associate and dissociate – critical for deciphering disease mechanisms and assessing drug interactions. With our technology, you can have improved confidence in lead selection, especially for hard-to-drug targets. Why conduct multiple experiments when you can just run one? With our MFS platform, you get the full story, all at once.

We’ve teamed up with Professor Matthew Disney and his team at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology to explore potential therapeutic approaches for diseases like #HuntingtonsDisease and #SpinocerebellarAtaxia. Using our magnetic force spectroscopy (MFS) platform, our team has explored small molecules targeting RNA repeat expansions linked to these neurological diseases. We conducted force ramp experiments to assess the stability of RNA structures, focusing on the interaction between MBNL1 protein and r(CAG)21 RNA. We then repeated these experiments with three specially designed small molecules to evaluate their impact on RNA structural stability and MBNL1 binding. What did we learn? 📊 MBNL1 binding decreases the stability of r(CAG)21, making it more likely to unfold and further entrap more MBNL1 molecules. 💡Our MFS platform also provided detailed, real-time insights into complex interactions at the single-molecule level, revealing the mechanistic effects of small molecules on RNA-protein dynamics. 🧬 The findings suggest that specific small molecules may interfere with RNA refolding and influence RNA-protein dynamics, offering a potential therapeutic approach. This study shows how our MFS platform is advancing the study of RNA-targeting therapeutics, helping to identify small molecules that could disrupt harmful RNA structures and restore normal protein function. If you could directly observe how small molecules interact with disease-associated RNA, what would you explore? To learn more about the study, read the article on our website: https://lnkd.in/eBtxwUCj #RNATherapeutics #DrugDiscovery #Biotech #Interactomics

Exploring the intricacies of protein-DNA interactions? Check out the data we collected using our magnetic force spectroscopy (MFS) platform to explore non-homologous end joining (NHEJ)👇 NHEJ is an essential DNA repair process. To characterize the binding kinetics and stability of the NHEJ protein complex, we first attached two blunt double stranded DNAs at a fixed distance apart along a DNA scaffold, tethered between a surface and a paramagnetic bead. We then added the NHEJ proteins Ku70-Ku80 and APLF and applied force cycles to the beads. What did we learn? 🔬 Using our MFS platform, we conducted force cycle experiments, cycling between three forces (0.01 pN, 2 pN, and 20 pN), to study the interactions between dsDNA blunt ends and NHEJ proteins. 📈 At 0.01 pN, the scaffold was relaxed bringing the two blunt ends into proximity. Without any protein binding, increasing the force to 2 pN fully stretched the scaffold, as seen in the dark blue trace. 🚧 When the NHEJ proteins Ku70-Ku80 and APLF were bound to the dsDNA blunt ends, a 2 pN force resulted in a transient blockage in the rising of the bead, as depicted in the light blue trace. ⚖️ This blockage is due to Ku70-Ku80 binding to each dsDNA blunt end, with APLF connecting the two. This effectively stabilizes the structure and resists the applied force. Our MFS platform offers a powerful tool for investigating a wide range of protein-DNA interactions as well as other molecular interactions. Interested in learning how it can advance your research? Let's connect and discuss your specific needs. Book a call with our Chief Commercial Officer, Steve Klose: https://lnkd.in/d_iHHujE #ProteinDNAInteraction #MolecularBiology #ProteinBinding #DNAResearch