Giuseppe Testa and colleagues report that copy number variations at 7q11.23 alter the kinetics of #neuronal maturation, ribosomal biogenesis, the mTOR pathway, and neuronal intrinsic excitability: https://lnkd.in/e-McxxwH Authors: Marija Mihailovich, Pierre-Luc Germain, Reinald Shyti, Davide Pozzi, Roberta Noberini, Yansheng Liu, Davide Aprile, Erika Tenderini, Flavia Troglio, Sebastiano Trattaro, Sonia Fabris, Ummi Ciptasari, Marco Tullio Rigoli, Nicolò Caporale, Giuseppe D'Agostino, Filippo Mirabella, Alessandro Vitriolo, Daniele Capocefalo, Adrianos Skaros, Agnese Virginia Franchini, Sara Ricciardi, Ida Biunno, Antonino Neri, Nael Nadif Kasri, Tiziana Bonaldi, Rudolf Aebersold, Michela Matteoli, Giuseppe Testa #Neuroscience
Post di The Journal of Clinical Investigation
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Exploring Cell Division: Mitosis, Meiosis & Cytokinesis 🧬 Explore the intricate dance of cell division, from the significance of mitosis and meiosis to molecular choreography and health implications. Unravel the mysteries shaping life's fundamental processes. Know More: https://lnkd.in/dwQnGkX3 #cellbiology #ScienceExploration #geneticcode #ResearchInsights #Lifeprocesses #HealthScience #biologydiscoveries
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Dirigente e Allenatrice di Ginnastica Dinamica Militare Italiana - Centro e Sud Italia
Grazie per aver condiviso un video così illuminante che mostra tutti gli organi presenti nel corpo umano. È stato davvero interessante e istruttivo poter osservare la complessità e la bellezza del nostro corpo. Guardando il video, mi ha colpito ancora di più quanto il nostro corpo sia veramente un miracolo della natura. Ogni organo, ogni sistema, ogni cellula lavora insieme in perfetta armonia per mantenerci in vita e in salute. È davvero un tesoro prezioso che ci è stato donato. Tuttavia, guardando il video, mi ha anche ricordato quanto sia importante prendersi cura di questo tesoro ogni giorno. Il nostro corpo è perfetto, sì, ma dobbiamo essere noi a curarlo con le nostre azioni quotidiane. Uno stile di vita corretto, basato su una sana alimentazione, esercizio fisico adeguato e cure preventive, è essenziale per mantenerlo in salute e in forma. Il nostro corpo è l'unico luogo in cui dobbiamo vivere per tutta la vita, ed è nostro dovere garantire che sia un luogo sano e accogliente. Prendercene cura non riguarda solo l'aspetto esteriore, ma è un concetto ad ampio spettro che coinvolge anche la nostra salute mentale. È importante quindi dedicare del tempo a noi stessi, praticare attività che ci rilassino e ci ricarichino, e cercare supporto quando ne abbiamo bisogno. Il benessere psico-fisico è un obiettivo che dovremmo perseguire costantemente, perché solo quando ci prendiamo cura di noi stessi in modo completo possiamo vivere una vita piena e soddisfacente.
𝑨 𝑪𝒐𝒎𝒑𝒍𝒆𝒕𝒆 𝑮𝒖𝒊𝒅𝒆 𝒕𝒐 𝑴𝒖𝒔𝒄𝒍𝒆𝒔 𝒊𝒏 𝒀𝒐𝒖𝒓 𝑩𝒐𝒅𝒚 There are over 650 muscles in your body: Muscles fall into different categories, each with its unique function and contribution. 1. Skeletal muscles, attached to bones, power your voluntary movements like walking and jumping. 𝐋𝐚𝐬𝐭 𝐂𝐡𝐚𝐧𝐜𝐞 𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐒𝐚𝐦𝐩𝐥𝐞 𝐂𝐨𝐩𝐲 𝐨𝐟 𝐑𝐞𝐩𝐨𝐫𝐭👉 https://lnkd.in/gikYGS7g 2. Smooth muscles, found in your internal organs, control involuntary processes like digestion. 3. Cardiac muscles keep your heart tirelessly beating, ensuring the circulation of blood and oxygen. Credit: SciePro #biology #neuroscience #medicine
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Science Artist 🧬 Let's get your Science the Attention & Impact it deserves 🎨 Molecular Graffiti, Illustrations & Animations 🎓 Training Scientists in visual Literacy
🧬🏺✨ DNA meets Mythology - Molecular Cell cover of mine illustrating Cohesin as the two-faced god Janus: Check out the idea behind it 👇 Cohesin is a highly conserved protein complex binding Chromosomes which is famous for doing two things: A) Keeping the sister chromatids together and B) driving DNA loop extrusion. But are these two aspects of Cohesin Biology based on the same function or are there independent mechanisms behind them? Kota Nagasaka from Jan-Michael Peters lab at the Research Institute of Molecular Pathology (IMP) figured it out! They generated a Cohesin mutant that can still mediate loop extrusion, but is deficient in sister chromatid cohesion. So this cover artwork depicts Cohesin as Janus, the two-faced ancient roman god of duality and passages, symbolizing the dichotomy of Cohesin's two functions. Curious about details? Check out the paper: https://lnkd.in/gtrPWn5V
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Vorresti guidare il laboratorio di Cito-Istopatologia nella trasformazione digitale? Grazie alla collaborazione tra Bio-Optica e KFBIO ora potrai farlo. Scopri gli scanner di vetrini per Digital Pathology! Leggi di più sul nostro sito https://lnkd.in/dV3WFV8z #improvingpathology #biooptica #milano #italy #madeinitaly #anatomicalpathology #anatomicpathology #histology #histologylab #histopathology #cytology #pathology #pathologist #immunohistochemistry #anatomiapatologica #istologia #citologia #diagnostics #healthcare #innovation #embedding #embeddingstation #tissueprocessor #microtome #digitalpathology #digitalscanner #kfbio
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MSCA postdoctoral fellow @ Karolinska Institutet | Researcher in liver development and regeneration
Me and my colleague Lenka Belicova are on a mission to share with you the unexpected beauty of the liver! As researchers, we have studied the fascinating biology of the liver through the microscope 🔬 over the past 7 years. There is more to the liver than the red-brown mass one can see on the outside. Check out our page to see the beauty ✨ of this crucial organ with your own eyes! #microscopy #liverisbeautiful #hepatology #cellbiology
Welcome to Discover Liver! The liver is not traditionally seen as a pretty organ, but we believe that there is more to it than the red-brown mass one can see on the outside. On this page, researchers share with you the beauty of the liver ✨ , which we get to see through the microscope 🔬 on a daily basis. Discover the hidden beauty of this crucial organ and gain a deeper appreciation for your liver. Check out our website for more content: www.discoverliver.com Follow us also on instagram: https://lnkd.in/dfJGRKYj and facebook: https://lnkd.in/d7PcJyRt #microscopy #liverisbeautiful #hepatology #cellbiology
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📢 Scopriamo i progetti #𝐏𝐑𝐈𝐍 - 𝐏𝐫𝐨𝐠𝐞𝐭𝐭𝐢 𝐝𝐢 𝐑𝐢𝐥𝐞𝐯𝐚𝐧𝐭𝐞 𝐈𝐧𝐭𝐞𝐫𝐞𝐬𝐬𝐞 𝐍𝐚𝐳𝐢𝐨𝐧𝐚𝐥𝐞 𝟐𝟎𝟐𝟐 di #Ipcb_Cnr: 𝙎𝙝𝙖𝙧𝙚𝙙 𝙥𝙝𝙚𝙣𝙤𝙢𝙞𝙘𝙨, 𝙜𝙚𝙣𝙤𝙢𝙞𝙘𝙨, 𝙖𝙣𝙙 𝙛𝙪𝙣𝙘𝙩𝙞𝙤𝙣𝙖𝙡 𝙜𝙡𝙮𝙘𝙤𝙢𝙞𝙘𝙨 𝙛𝙤𝙧 𝙗𝙚𝙩𝙩𝙚𝙧 𝙉-𝙂𝙇𝙔𝙘𝙤𝙨𝙮𝙡𝙖𝙩𝙞𝙤𝙣 𝙚𝙫𝙖𝙡𝙪𝙖𝙩𝙞𝙤𝙣 𝙖𝙣𝙙 𝙩𝙖𝙧𝙜𝙚𝙩𝙞𝙣𝙜 𝙞𝙣 𝙉𝙀𝙐𝙧𝙤𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙢𝙚𝙣𝙩𝙖𝙡 𝙙𝙞𝙨𝙤𝙧𝙙𝙚𝙧𝙨 (𝙉𝙂𝙇𝙔𝙉𝙀𝙐) 𝘓𝘚1 - 𝘔𝘰𝘭𝘦𝘤𝘶𝘭𝘦𝘴 𝘰𝘧 𝘓𝘪𝘧𝘦: 𝘉𝘪𝘰𝘭𝘰𝘨𝘪𝘤𝘢𝘭 𝘔𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴, 𝘚𝘵𝘳𝘶𝘤𝘵𝘶𝘳𝘦𝘴 𝘢𝘯𝘥 𝘍𝘶𝘯𝘤𝘵𝘪𝘰𝘯𝘴 N-glycosylation #neurodevelopmentaldisorders Congenital Disorders of #Glycosylation #glycogenes Functional #glycomics Microphenotype Leggi la scheda per saperne di più 👇 Consiglio Nazionale delle Ricerche - Università di Catania - Università degli Studi di Urbino Carlo Bo
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Witness the remarkable meeting point of the fallopian tube and the uterus - the isthmus, brought to you by Dr. Kate O'Neill and Dr. Junhyong Kim from the University of Pennsylvania using PhenoCycler. It's truly egg-ceptional! Blue = nuclei Pink = epithelial cells Green = extracellular matrix Orange = T cells Teal = lymphatics Red = smooth muscle cells Learn how spatial biology can help you discover novel insights in human biology, spanning a continuum from discovery to clinical and translational research. https://bit.ly/44bI8Xw #tissuetuesday #spatialbiology #singlecell #immunooncology #HuBMAP
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Orexin receptors are proteins located on the surface of nerve cells in the brain and other tissues of the body that respond to orexin, also known as hypocretin. Orexin is a neuropeptide that plays a crucial role in regulating sleep, wakefulness, and feeding. There are two main types of orexin receptors, known as OX1 and OX2, which are members of the G protein-coupled receptor (GPCR) family. In this study, the homology structure of OXR1 was obtained using Modeller 10.4, based on the PDB model 6TO7. The CHARMM-GUI server was used to embed the receptor in a POPC bilayer membrane. The orexin 1 peptide was obtained from the PDB model 1CQ0. (PDB code: 1CQ0) Rendering by Prof. Caio Sena (@prof_caiosena) made with #proteinimager Try it here https://lnkd.in/dc8yQfy #OrexinReceptors #Neuropeptide #Hypocretin #SleepRegulation #Wakefulness #FeedingBehavior #GPCR #ProteinStructure #HomologyModeling #Modeller #Bioinformatics #Neuroscience #MolecularBiology #StructuralBiology #3DModeling #Research #Science #PDB #OXR1 #OX1 #OX2
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I risultati sono stati pubblicati in un articolo su Sciences Advances
Proteina spia per i tumori del fegato individuata dai ricercatori dell'Università di Trento: “Mutazione di un gene collegata allo sviluppo di neoplasie gravi”
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