European Annals of Allergy and Clinical Immunology

It's a great honor to confirm, 𝗳𝗼𝗿 𝘁𝗵𝗲 𝘀𝗲𝗰𝗼𝗻𝗱 𝘆𝗲𝗮𝗿 𝗰𝗼𝗻𝘀𝗲𝗰𝘂𝘁𝗶𝘃𝗲𝗹𝘆, the achievement of the 𝕀𝕄ℙ𝔸ℂ𝕋 𝔽𝔸ℂ𝕋𝕆ℝ: 𝟮.𝟲 during the year 2023. +0.3 𝘱𝘰𝘪𝘯𝘵𝘴 𝘪𝘯 𝘤𝘰𝘮𝘱𝘢𝘳𝘪𝘴𝘰𝘯 𝘸𝘪𝘵𝘩 𝘵𝘩𝘦 2022. Thanks to everyone who recognize - every single day - our Journal as a serious product for #professional growth and #knowledge diffusion in the field of #allergy and #immunology. AAIITO Società Scientifica

#Epistaxis is common in allergic rhinitis patients. This study retrospectively analyzed the #efficacy and #safety of sublingual immunotherapy (SLIT) in AR patients with epistaxis. 74 patients aged 4-60 years with 𝗵𝗼𝘂𝘀𝗲 𝗱𝘂𝘀𝘁 𝗺𝗶𝘁𝗲 (HDM)-induced AR and epistaxis completed one year of SLIT with #Dermatophagoides farinae drops. Assessments and examinations were as follow: ➡️ symptom scores ➡️ total medication scores ➡️ combined symptom and medication scores ➡️ visual analog scales ➡️ bleeding scores ➡️ nasal endoscopic

Many food allergens not listed as priorities in Europe can still trigger severe allergic reactions and may go unnoticed as "hidden allergens." The rise of #plantbased diets, new #sustainable foods, and specific food #additives has led to the emergence of new allergens that are significant for public health. Understanding hidden allergens is crucial for both doctors and patients to enhance the #prevention, #diagnosis, and #treatment of food allergies, reducing the risk of 𝗺𝗶𝘀𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝗻𝗴 𝗶𝗱𝗶𝗼𝗽𝗮𝘁𝗵𝗶𝗰 𝗮𝗻𝗮𝗽𝗵𝘆𝗹𝗮𝘅𝗶𝘀. The review by 𝗚𝗶𝘂𝘀𝗲𝗽𝗽𝗲 𝗣𝗮𝗿𝗿𝗶𝗻𝗲𝗹𝗹𝗼, 𝗗𝗲𝘀𝗿é 𝗘𝘁𝗵𝗲𝗹 𝗙𝗼𝗻𝘁𝗮𝗻𝗮, 𝗗𝗮𝗻𝗶𝗹𝗼 𝗩𝗶𝗹𝗹𝗮𝗹𝘁𝗮 outlines the characteristics of common hidden allergens and their diagnostic methods. A thorough history, careful review of ingredient lists, awareness of potential cross-reactions or contamination, along with allergological evaluations using "in vivo" or "in vitro" tests, and oral food challenges when necessary, are recommended for accurate identification of the responsible #allergen. Moving forward, it is essential to advance these diagnostic tools, particularly in molecular allergology, and to mandate allergen #labeling on food products.

A research led by Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Giovanna Achilli­­, and Antonio Di Sabatino explores the link between Omega-5 #gliadin allergy and recurrent acute #urticaria. This study highlights the importance of recognizing this specific allergy in patients with chronic urticaria, paving the way for more 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗲𝘀 𝗮𝗻𝗱 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀. 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀 ➡️ Identification of #Omega5 gliadin as a significant #allergen. ➡️ Correlation between this allergy and recurrent acute urticaria. ➡️ Potential for improved patient #outcomes through targeted allergy testing.

#Adrenaline auto-injector (AAI) training is crucial, but standards for visual training platforms are unclear. This study evaluated the 𝗿𝗲𝗹𝗶𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 of AAI-related YouTube videos. #YouTube videos on AAI were categorized by origin and content aim. Quality, reliability, understandability, and actionability were assessed using the Global Quality Scale (GQS), PEMAT-A/V, DISCERN, and a modified DISCERN. Correct usage steps were also evaluated. 107 English videos were analyzed. No significant differences in #views, #likes, duration, or upload time were found 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗵𝗲𝗮𝗹𝘁𝗵 𝗮𝗻𝗱 𝗻𝗼𝗻-𝗵𝗲𝗮𝗹𝘁𝗵 𝗴𝗿𝗼𝘂𝗽𝘀. However, health group videos had higher GQS, DISCERN total, and modified DISCERN scores. 𝗘𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝘃𝗶𝗱𝗲𝗼𝘀 𝗴𝗲𝗻𝗲𝗿𝗮𝗹𝗹𝘆 𝘀𝗰𝗼𝗿𝗲𝗱 𝗵𝗶𝗴𝗵𝗲𝗿. AAI use was mentioned in 85% of videos, with a median of 6 steps. YouTube is effective for AAI visual learning. Videos by medical #professionals offer the most reliable information. İstanbul Üniversitesi

The study led by João Cardoso Lopes evaluates allergic emergencies in the prehospital context in #Portugal, based on five years of data from a Portuguese emergency centre. The study found that 1.7% of emergency calls were related to suspected hypersensitivity reactions, with the main causes being #Hymenoptera venom (29.9%), food allergies (29.1%), and #medication (25.2%). 59.8% of cases met the criteria for anaphylaxis, but only 34.7% were diagnosed on-site. #Epinephrine was administered in just 39.4% of cases, which indicates underutilization. This research underscores the need for 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝘀, 𝗮𝗽𝗽𝗿𝗼𝗽𝗿𝗶𝗮𝘁𝗲 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗮𝘁 𝘁𝗵𝗲 𝘀𝗰𝗲𝗻𝗲, 𝗮𝗻𝗱 𝘀𝗽𝗲𝗰𝗶𝗮𝗹𝗶𝘇𝗲𝗱 𝗳𝗼𝗹𝗹𝗼𝘄-𝘂𝗽 𝗰𝗮𝗿𝗲 𝗮𝗳𝘁𝗲𝗿 𝗽𝗿𝗲𝗵𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝗲𝘃𝗲𝗻𝘁𝘀. These findings are crucial for improving prehospital care for severe allergic reactions. Co-authors: Jóni Costa Carvalho, Helena Pires Pereira, Inês Costa Farinha, Pedro Botelho Alves, Fabiana Pimentel, Carmelita Ribeiro, Ana Todo-Bom

Limited evidence exists on #𝗱𝗿𝘂𝗴 𝗽𝗿𝗼𝘃𝗼𝗰𝗮𝘁𝗶𝗼𝗻 𝘁𝗲𝘀𝘁𝘀 (DPT) with chemotherapeutic agents. 𝗝𝗼𝗮𝗻𝗮 𝗤𝘂𝗲𝗶𝗿ó𝘀 𝗚𝗼𝗺𝗲𝘀, 𝗟𝗶𝗹𝗶𝗮𝗻𝗮 𝗣𝗮𝘁𝗿í𝗰𝗶𝗮 𝗣𝗲𝗿𝗲𝗶𝗿𝗮 𝗗𝗶𝗮𝘀, 𝗣𝗮𝘁𝗿í𝗰𝗶𝗮 𝗕𝗮𝗿𝗿𝗲𝗶𝗿𝗮, 𝗝𝗼𝗮𝗻𝗮 𝗕𝗮𝗿𝗿𝗮𝗱𝗮𝘀 𝗟𝗼𝗽𝗲𝘀, 𝗠𝗮𝗿𝗶𝗮 𝗝𝗼ã𝗼 𝗦𝗼𝘂𝘀𝗮, 𝗦𝘂𝘀𝗮𝗻𝗮 𝗖𝗮𝗱𝗶𝗻𝗵𝗮 and 𝗗𝗮𝗻𝗶𝗲𝗹𝗮 𝗠𝗮𝗹𝗵𝗲𝗶𝗿𝗼 described DPT experiences in patients with hypersensitivity reactions (HSRs) to #antineoplastic and biological agents. An eight-year retrospective study of patients with HSRs to #chemotherapy who underwent DPT. 54 patients underwent DPT. Suspected drugs: platins (n = 36), taxanes (n = 11). Initial reactions were mostly grade II. STs were negative except one positive intradermal test with #paclitaxel. 𝟲𝟰 𝗗𝗣𝗧𝘀 𝘄𝗲𝗿𝗲 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗲𝗱 ➡️11% were positive 𝟱𝟳 𝗥𝗦𝗔𝘀 ➡️2 were positive (platins)

Maria Bernadette Cilona, Giuseppe Alvise Ramirez, Chiara Asperti, et al.(*) conducted a systematic review using databases like #PubMed, #Scopus, and Web of Science, with the aim to compare the #incidence of severe reactions in patients with and without #asthma. Eight studies with 90,367 patients were included. Among 28,166 patients with #food allergies, those with asthma 𝗵𝗮𝗱 𝗮 𝗵𝗶𝗴𝗵𝗲𝗿 𝗶𝗻𝗰𝗶𝗱𝗲𝗻𝗰𝗲 𝗼𝗳 𝘀𝗲𝘃𝗲𝗿𝗲 𝗿𝗲𝗮𝗰𝘁𝗶𝗼𝗻𝘀. It can be concluded that patients with both food allergies and asthma are at a higher risk of severe, potentially #fatal reactions. #Healthcare professionals should prioritize #prevention and #management for these patients. (*) Arianna Ferlito, Giovanni Benanti, Serena Nannipieri, Rawad Mansour Abdul Hadi, Carlo Capellini, Lorenzo Dagna, Cottini Marcello, Mona-Rita Yacoub

The study from a #Portuguese tertiary center and signed by Cláudia Varandas, 𝗝𝗼𝘀𝗲𝗳𝗶𝗻𝗮 𝗩𝗶𝗲𝗶𝗿𝗮, Catarina Jacinto Correia, Marisa Paulino, Amélia Spínola santos, 𝗔𝗻𝗮𝗯𝗲𝗹𝗮 𝗟𝗼𝗽𝗲𝘀, 𝗦𝘂𝘀𝗮𝗻𝗮 𝗟𝗼𝗽𝗲𝘀 𝗗𝗮 𝗦𝗶𝗹𝘃𝗮, 𝗘𝗹𝗶𝘀𝗮 𝗣𝗲𝗱𝗿𝗼, 𝗝𝗼𝗮𝗻𝗮 𝗖𝗮𝗶𝗮𝗱𝗼 reviewed hypersensitivity reactions (HSR) to #iron products (IP) over a decade. The study involved 18 patients, predominantly #women, with reactions mainly to 𝗳𝗲𝗿𝗿𝗶𝗰 𝗰𝗮𝗿𝗯𝗼𝘅𝘆𝗺𝗮𝗹𝘁𝗼𝘀𝗲. Most reactions were mild, but severe cases were also noted. The study highlights the #effectiveness of re-administration and desensitization protocols, emphasizing the importance of slow infusion rates and individualized patient #management. These findings support the #safety of 𝗿𝗲-𝗰𝗵𝗮𝗹𝗹𝗲𝗻𝗴𝗶𝗻𝗴 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗮𝗹𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝘃𝗲 𝗼𝗿 𝗲𝘃𝗲𝗻 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝗜𝗣, contributing valuable insights into managing HSR to iron products.

𝗛𝗼𝗺𝗮 𝗦𝗮𝗱𝗿𝗶, 𝗔𝘁𝗼𝘀𝘀𝗮 𝗠𝗮𝗱𝗮𝗻𝗶𝗽𝗼𝘂𝗿, 𝗡𝗲𝗴𝗮𝗿 𝗧𝗼𝗮𝗺𝗶, 𝗠𝗮𝗵𝗺𝗼𝗼𝗱 𝗕𝗮𝗸𝗵𝘁𝗶𝗮𝗿𝗶, 𝗛𝗮𝗱𝗶 𝗠𝗼𝗻𝘁𝗮𝘇𝗲𝗿𝗹𝗼𝘁𝗳𝗲𝗹𝗮𝗵𝗶, 𝗘𝗵𝘀𝗮𝗻 𝗭𝗮𝗵𝗺𝗮𝘁𝗸𝗲𝘀𝗵, Zandifar Atefeh and marzieh tavakol suggested that #inflammation from #allergies may increase #seizure risk in children. 𝗡𝗼 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗹𝗶𝗻𝗸 𝘄𝗮𝘀 𝗳𝗼𝘂𝗻𝗱 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀 𝗮𝗻𝗱 𝘀𝗲𝗶𝘇𝘂𝗿𝗲𝘀. However, febrile #convulsions were associated with the number of 𝗰𝗼𝗺𝗼𝗿𝗯𝗶𝗱 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀. A significant link was also found between mothers’ allergic diseases and idiopathic #epilepsy in children indicating that 𝗺𝗼𝘁𝗵𝗲𝗿𝘀’ 𝗮𝗹𝗹𝗲𝗿𝗴𝗶𝗰 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗺𝗼𝗿𝗲 𝘀𝘁𝗿𝗼𝗻𝗴𝗹𝘆 𝗹𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗶𝗱𝗶𝗼𝗽𝗮𝘁𝗵𝗶𝗰 𝗲𝗽𝗶𝗹𝗲𝗽𝘀𝘆 in children than fathers’.