adthera bio

🚀 Scaling Cell Therapy Manufacturing with the Right Automation Platforms 🚀 The majority of cell therapies manufactured today rely on a series of modular devices—but selecting the right platform for each step is critical to ensuring a cost-effective, closed, and scalable process from clinical development through to commercial supply. At adthera, our process development team specializes in automation solutions across key unit operations, including: 🔹 Starting Material Washing – Efficient removal of contaminants while maintaining cell viability 🔹 Cell Selection – High-purity enrichment with optimized recovery 🔹 Cell Expansion – Scalable solutions for high-yield manufacturing 🔹 Final Fill & Finish – Closed-system aliquoting to ensure product integrity and regulatory compliance The platforms (Fresenius Kabi LOVO, Miltenyi Biotec Clinimacs, ScaleReady Grex, Fresenius Kabi CUE) you see in today’s video have successfully been deployed by us to generate in excess of 4 billion gamma-delta T cells in a fully closed, GMP-ready process. 🌍💉 💡 Whether you’re optimizing a clinical-stage process or scaling towards commercialization, adthera can help you: ✅ Identify the right automation platform for your therapy ✅ Reduce manual interventions and enhance regulatory compliance ✅ Improve yield, efficiency, and cost-effectiveness 📩 Reach out if you’d like to hear more or want to learn how we can help you accelerate your pipeline! Connect with the team ( Colin Sims, Stuart Curbishley, Kwok Pang, Matt Symes) tomorrow at Terrapinn advanced therapies! Learn more at info@adthera.bio | adthera.bio #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment Terumo Blood and Cell TechnologiesSexton Biotechnologies

🌐 Introducing adthera bio's digital simulations for Ballroom Manufacturing: Enhancing Compliance and Efficiency 🏭 In our recent poll, we asked the community about the biggest risks of operating a scaled-out ballroom cleanroom with paper records and procedural controls. The response was clear: operational management, containment breach investigations, and batch deviation management are critical pain points. At adthera bio, we're taking a proactive approach to address these challenges by leveraging our GMP simulation suite and digital twin technology from OUAT!. Our virtual evaluation tools allow you to: 🔍 Simulate Operational Models: Evaluate process flows, operator movements, and scenario simulations without impacting live production. 📈 Enhance Risk Mitigation: Virtually test manufacturing models, from small setups (4 workstations) to larger, complex systems (15+ workstations) with dedicated fill suites. 🛡️ Support Compliance: Ensure traceability and compliance in parallel manufacturing environments for advanced therapies. 💡 Curious about how this works? Let's connect and explore how we can support your manufacturing model's efficiency and compliance. 📩 Contact our experts: Kwok Pang, Chief Digital Officer Stuart Curbishley, Chief Development & Manufacturing Officer 👉 Visit us at adthera.bio 💬 What challenges are you facing in your operational models? How could a digital twin enhance your approach to advanced therapy manufacturing? Share your thoughts below! #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment

The adthera team is Heading to Advanced Therapies 2025! 🌟 Team adthera will be attending the Terrapinn Advanced Therapies 2025 conference at ExCeL London on March 18-19. This is a fantastic opportunity to connect, collaborate, and discuss the future of cell and gene therapy! 👥 Meet Our Team: Colin Sims, Chief Executive Officer Kwok Pang, Chief Digital Officer Stuart Curbishley, Chief Development & Manufacturing Officer Matt Symes, Head of Strategy & Finance We’d love to connect with innovators, partners, and thought leaders who are passionate about advancing the industry. Whether you’re exploring digital innovations in cell and gene , navigating the CDMO landscape, or simply want to exchange ideas, reach out to us at info@adthera.bio or connect directly on LinkedIn. Let’s make strides together towards transforming advanced therapies and delivering life-changing treatments to patients! #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #cdmo #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment

✅ Poll Results Are In: Top 2 area of CGT Manufacturing is in Final Fill & Finish and Expansion! ✅ Thank you to everyone who participated in our recent LinkedIn poll on CGT manufacturing automation! 🗳️ The results are clear—Final Fill & Finish has emerged as one of the two area where the greatest opportunity for automation and process optimization lies. 📢 So, what’s next? We have been working on the Fresenius Kabi #Cue system to develop key considerations for Final Fill automation and how the Fresenius Kabi Cue system offers a path to a closed, semi-automated final product filling solution. Some of the key findings include: 🔹 Current Challenges – Many final fill processes still require operator intervention, increasing risk and variability. 🔹 Opportunities for Improvement – Closed-system automation can streamline handling, improve residual washout, and enhance GMP compliance. 💡 How the Cue Device Optimizes Final Fill & Finish 💡 The Fresenius Kabi Cue system has been identified as the leading solution for improving precision, automation, and compliance in final fill processes. Why? ✔️ Precision Filling at Low Volumes – Unlike conventional systems, Cue ensures accurate dispensing even at low volumes, minimizing overfill and product loss. ✔️ Flexible Container Compatibility – The system accommodates varied container types, including cryobags and CellSeal vials, supporting clinical and commercial needs. ✔️ Efficient Washing & Residual Removal – Cue’s spinner membrane filtration enables high-efficiency washout, reducing residual contaminants by over 97%, a key improvement over existing systems. ✔️ Optimized Process Control – With automated sampling points and real-time monitoring, Cue enhances process consistency while reducing manual interventions. ✔️ Regulatory & GMP Compliance – The system operates in a functionally closed manner, supporting ISO 8/Grade C environments while ensuring compliance with stringent cGMP regulations. 📢 adthera Bio: Your Partner in Final Fill Optimization At adthera, we specialize in evaluating and implementing automation solutions to streamline CGT manufacturing. If you’re looking to enhance fill-finish precision, reduce manual handling, and optimize compliance, our team can support you with: 🔬 Final Fill strategy assessment 🔧 Automation feasibility studies 🛠️ Process optimization and validation 📩 Interested in discussing your final fill strategy? Reach out to adthera today and let’s explore how we can enhance your CGT manufacturing workflow! #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #celltherapymanufacturing #innovation #digital #partnerships #collaboration #GMP #simulation #manufacturing #processdevelopment Terumo Blood and Cell Technologies Sexton Biotechnologies ScaleReady

🚀 The Future of CGT Manufacturing: Which leading edge technology should we bring in next? 🚀 The cell and gene therapy (CGT) industry is evolving fast, and automation is at the heart of scaling up efficiency, consistency, and patient access. But where should we focus our digitization and automation efforts? 🤔 We're running a quick LinkedIn poll to hear from YOU—our community of CGT professionals, innovators, and problem-solvers. 📊 Which CGT manufacturing process would benefit most from automation? 🔹 Cell washing 🔹 Selection 🔹 Expansion 🔹 Fill/finish 💡 Vote now and share your insights in the comments! What challenges are you seeing in these steps? Have you implemented automation in your workflow? Let's spark a discussion that helps shape the future of CGT manufacturing! ⚙️🔬 📢 Don’t just vote—tag your network! Invite your colleagues, peers, and industry leaders to weigh in. The more voices, the better the insights! Learn more at info@adthera.bio | adthera.bio #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment

Farewell to the Cocoon Platform – On to Its European Tour! 🌍✨ At adthera, we’re saying goodbye (for now) to the Lonza Cocoon platform as it embarks on its European journey. A huge thank you to Lonza for providing this advanced technology during its time with us! But Cocoon was just one piece of the puzzle. As we continue to redefine the future of cell & gene therapy manufacturing, we’ve built an ecosystem that hosts best-in-class technologies from leading innovators, including: 🔹 Miltenyi Biotec – CliniMACS Prodigy 🔹 Cytiva – Sefia platform 🔹 Fresenius Kabi – Lovo & Cue 🔹 ChemoMetec -Nucleocounter 🔹 Sexton Biotechnologies – CellSeal® CT5 🔹 Adva Biotechnology – Adva X3 platform 🔹 Ori Biotech – IRO platform 🔹 ScaleReady – G-Rex platforms 🔹 MaxCyte, Inc. – Electroporation devices We’re not stopping here—innovation never stands still! 🚀 Which cutting-edge platform should we bring in next? If you're a technology provider with a game-changing solution for CGT manufacturing, let’s talk! Learn more at info@adthera.bio | adthera.bio #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment Adrian A.

Our NucleoCounter has been animated! ChemoMetec was featured in Adthera Bio's animation on scaling CGT manufacturing.   Their GMP simulation suite (powered by OUAT! tech) uses digital twin technology to model scenarios and mitigate risks - a fresh perspective that emphasizes a digital-first strategy for compliant, scalable CGT production. #CGT #manufacturing #digitaltwin #innovation #OUAT #cellcounting #nucleocounter

🚀 Scaling Out Cell & Gene Therapy Manufacturing: A Digital Approach to Risk Mitigation 🏭 We’re excited to share how adthera bio is leveraging digital twin technology to tackle these challenges head-on. 🔹 Our GMP simulation suite—now virtualized using OUAT! technology—enables us to assess different scaled-out manufacturing strategies: 1️⃣ 4-workstation model 2️⃣ Ballroom-style model with 15+ workstations 3️⃣ 8-workstation model with an associated final fill room By simulating process, people, and material flows, we can identify risks and compliance concerns before implementation—ensuring robust manufacturing continuity and scalability from hundreds to thousands of batches in a compliant environment. In addition, we are planning to test digital solutions in our physical GMP simulation suite to transform the level of visibility in the manufacturing space. 🔬 Key considerations in our risk assessment & digitalisation study: ✅ Process closure is essential—open manufacturing steps must be mitigated before a Grade C ballroom model is viable. ✅ Digital tools like RTLS & RFID are critical for tracking materials & personnel, reducing contamination risks in concurrent manufacturing. ✅ Automation & modular facility design provide scalability while maintaining operational flexibility. ✅ A digital-first strategy ensures regulatory compliance, enhances traceability, and optimizes production scheduling. 💡 The future of CGT manufacturing isn’t just about scale—it’s about intelligent, data-driven decision-making to mitigate risk and maintain uninterrupted GMP-compliant production. What’s your take? Have you encountered scalability challenges in CGT manufacturing? How are you mitigating risks in a high-throughput, multi-product environment? Join the conversation below! 👇 #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment Miltenyi Biotec ScaleReady Fresenius Kabi PHCbi Global Terumo Blood and Cell Technologies ChemoMetec

🔬 Scaling Out Cell & Gene Therapy Manufacturing: What Are the Key Risks? 🏭 The ballroom manufacturing model offers efficiency and scalability for Cell & Gene Therapy (CGT), but it comes with significant operational challenges—especially when relying on paper records & procedural controls. At adthera bio, we’ve been assessing these risks in depth, and we want to hear from the community! 📊 Poll: What do you see as the biggest risk in a scaled-out ballroom cleanroom using paper-based controls? 1️⃣ Risk assessment of containment failure (e.g., vector leak) with limited data 2️⃣ Managing manufacturing batch records effectively 3️⃣ Batch production scheduling – workforce & materials 4️⃣ Environmental & facility monitoring – volume & complexity The transition to digitalised and automated manufacturing is key, but for those currently operating in paper-driven environments, risk mitigation strategies must be robust. 💬 What’s your take? Have you faced challenges in a ballroom model? What steps do you see as critical to ensuring compliance and efficiency in a multi-product, concurrent manufacturing environment? Let’s start the discussion! 👇 Learn more at info@adthera.bio | adthera.bio #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #processdevelopment

🔗 Navigating Supply Chain Complexity in Life Sciences 🚀 Did you know that over 70% of IT projects fail? The top reasons? ❌ Poorly defined system requirements ❌ Lack of process maturity ❌ Unrealistic timelines ❌ Inaccurate budgeting At adthera, we understand that selecting and implementing the right supply chain system is critical for operational success. Our expert-led approach ensures: ✅ Clear definition & documentation of supply chain requirements ✅ Comprehensive vendor assessments to find the best-fit solutions ✅ Solution sandbox testing to match business needs ✅ Implementation & validation evaluation to determine total cost of ownership With decades of experience in life sciences and digital transformation, we help companies streamline operations, mitigate risks, and maximize ROI. 📩 Connect with Kwok Pang, our Chief Digital Officer, to see how we can help Learn more at info@adthera.bio | adthera.bio #cdmo #regenerativemedicine #digitalfirst #celltherapy #immunotherapy #innovation #processdevelopment #continousimprovement #gmp #clinicaltrials #atmp #advancedtherapies #personalizedmedicine #gxp #optimization #automation #bestinclass #rightfirsttime #celltherapymanufacturing #innovation #digital #partnerships #collaboration #networking #digitaltransformation #quailtycontrol #qualityassurance #GMP #simulation #manufacturing #supplychain #processdevelopment