Lightcast

We're thrilled to announce that our first scientific paper has been published in the Royal Society of Chemistry's "Lab on a Chip" journal. According to lead author Lawrence Welch, a Senior Scientist at Lightcast, the paper demonstrates the potential of the Lightcast platform to advance single-cell functional studies with unprecedented control, flexibility, and parallelization. "By overcoming the limitations faced by traditional microfluidics or droplet technologies and enabling real-time functional analysis, we aim to bring entirely new capabilities to scientists in drug discovery and life science research," he said. Read the press release and access the paper on our website: https://lnkd.in/eVkSYrGF

Traditional single-cell screening for drug discovery involves multiple sequential stages, with high attrition and costly functional validation steps. Researchers rely on indirect genomic and transcriptomic readouts, requiring secondary screens to confirm function—adding complexity, cost, and delays. A function-focused approach streamlines this process by integrating hit identification and functional screening early in drug discovery. By directly measuring key cellular functions—such as biomolecule secretion, blocking, cell-cell interactions, and target cell killing—nonfunctional candidates can be eliminated sooner, reducing attrition and accelerating development. 🔬 Want to learn more? Download our white paper now: https://lnkd.in/es6rqmDU #DrugDiscovery #SingleCellAnalysis #CellFunction #FunctionFocused #ResearchInnovation #CellTherapy

At NextGen Biomed by Oxford Global today? Drop by Booth 62 for a chat with Julian Ashby and Carrie M..

Happy to be back at #NextGenBiomed in London! Drop by Booth 62 to learn more about the Lightcast platform.

Will we see you at #NextGenBiomed this week? Drop by Booth 62 to chat with Julian Ashby and Carrie M. about how Lightcast can help streamline discovery workflows by enabling precise interrogation of single-cell interactions and functional behaviours at scale. Not in London this week? Visit our Events page to find out where we'll be this spring: https://lnkd.in/extfvCCt

I’m constantly inspired by the innovation, dedication, passion and resilience women bring to advancing science and shaping the future. It’s diversity, beyond gender, fuels innovation, fosters creativity, and helps us tackle complex challenges with unique perspectives and ideas. Let’s continue to inspire, support and empower one another to break barriers and make a lasting impact. Thanks to all the people at Lightcast I work with that help create this environment together !

Last week, we introduced one of our Luminary early-access partners: the Tech Watch team at VIB Technologies. Tech Watch occupies a unique niche in biomedical research, not only mediating access to breakthrough technologies for early-career researchers, but also providing key insights to the companies developing those technologies. In this video, Technology Expert Sarah Geurs tells us about the team's work, and about what drew her to join Tech Watch. 💡 Learn more about the Lightcast Luminary Programme: https://lnkd.in/eZy_Rp4s

In droplet-based single-cell analysis, cell distribution randomness is a major hurdle due to Poisson distribution. This often leads to droplets with multiple cells—or worse, empty ones. With typical droplet-based technologies, nearly three in four droplets may be rendered unusable, wasting researchers' most valuable resources: time and cells. This unpredictability can severely impact the reliability of your assays, with compounded issues when trying to carry out sequential assays. The Lightcast platform leverages machine learning algorithms to eliminate droplets with unwanted contents in real time, ensuring that only droplets with the desired single-cell occupancy are distributed across the experimental array. This game-changing solution enhances single-cell analysis and isolation, making your experiments more reliable and your data more reproducible. The Lightcast platform also enables multi-step workflows and sequential assays through precise droplet merging. From competition assays to serial killing, this unique capability simplifies complex workflows and helps you study dynamic biological processes with unprecedented precision. 📑 Download our new white paper to explore how the Lightcast platform can help you overcome cell distribution randomness and unlock powerful sequential assays: https://lnkd.in/eGZ2UY_a #SingleCellAnalysis #MachineLearning #DropletTechnology #DrugDiscovery #CellTherapy #SequentialAssays #Lightcast

In today’s rapidly evolving therapeutic landscape, understanding cellular behaviour is crucial. A function-focused approach recognises that all therapies—whether cell therapy, checkpoint inhibitors, therapeutic antibodies, or ADCs—are fundamentally rooted in the modulation of cellular functions to achieve therapeutic outcomes. This relies on capturing key functional outputs like: 1. Biomolecule secretion 2. Cell–cell interactions 3. Targeted cell killing 4. Antibody blocking 5. Internalisation This approach delivers invaluable insights, allowing researchers to evaluate therapeutic potential with greater precision. It reduces the reliance on secondary functional screening, ultimately streamlining workflows throughout the drug discovery process. 📑 Check out our new white paper for an in-depth look at how a function-focused strategy can transform your research and accelerate your drug development timeline: https://lnkd.in/eijnHHc8 #DrugDiscovery #TherapeuticDevelopment #FunctionFocused #DrugDevelopment #WhitePaper #CellTherapy #Biomolecules

What better way to start the week than by showcasing one of our incredible Luminary partners? We're lucky to count the Tech Watch team at the Flemish Institute for Biotechnology (VIB) among the members of our Luminary Programme. Working with early-access partners like VIB Technologies has given us the opportunity to continuously develop and improve the Lightcast platform in line with customer needs, which in turn empowers researchers to better understand single-cell heterogeneity and function. Thanks to Sarah Geurs, Toon Swings, and everyone at Tech Watch!