An investigator-initiated trial supported by Lightpoint has highlighted the safety profile and early feasibility of using SENSEI® with a 99mTc-PSMA-targeted tracer for the intraoperative detection of metastatic lymph nodes in primary prostate cancer, prior to robot-assisted radical prostatectomy. Building on previous results for sentinel node biopsy, the publication demonstrates the utility of Lightpoint’s drop in gamma probe at initial diagnosis, potentially broadening the application of this technology in the disease, where radioguided surgery with this tracer has typically been performed in the recurrent setting. Further research is now being conducted to confirm the ability of SENSEI and targeted radiation imaging agents to detect micrometastatic prostate cancer during surgery as well as exploring their use in other urologic and non-urologic malignancies. Read the paper below or visit https://lnkd.in/dekia9t for more on Lightpoint and SENSEI
Recently published in Clinical Nuclear Medicine, Harke et al. report that “radioguided surgery with the novel drop-in gamma probe - SENSEI - and 99mTc-PSMA-I&S allows for a safe intraoperative screening for lymph node metastases in robot-assisted radical prostatectomy for primary prostate cancer.“ Harke and colleagues conducted a retrospective study that included data from 13 patients with prostate cancer with a Briganti-Score nomogram risk score ≧ 10% and had no metastatic lesions as detected by conventional imaging. Patients underwent 99mTc-PSMA-I&S SPECT/CT imaging followed by robot-assisted radical prostatectomy with radioguided surgery using the SENSEI drop-in gamma probe. Sensitivity and specificity of the SENSEI probe ranged up to 78% and 100%, respectively, and no major complications were reported. https://lnkd.in/ge79ene4 SENSEI® has attained a marketing authorisation in the U.S., having been registered with the U.S. FDA and has attained a Conformité Européenne (CE) Mark for use in the European Economic Area for the intraoperative detection of sentinel lymph nodes.