Machine Medicine

What advancements are needed for brain stimulation systems to regulate physiology effectively? Dr Joram van Rheede from the University of Oxford discusses ways to advance brain stimulation systems as effective regulators of physiology, incorporating circadian rhythms and predictive modelling. While current systems utilize sensor data for biomarker detection, future models should integrate time-of-day awareness and anticipate physiological changes, including sleep patterns. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #DeepBrainStimulation #CircadianRhythms #NeuroscienceInnovation #HealthcareTechnology #WearableTech #ClinicalTrials #HealthTech

What does the study reveal about the effects of deep brain stimulation on sleep spindle activity and overall sleep structure? Dr Joram van Rheede from the University of Oxford examined sleep spindle activity using a validated algorithm adapted for local field potentials from deep brain stimulation (DBS) devices. Despite sparse data, the algorithm detected increased spindle activity, aligning with periods of high slow wave power. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #DeepBrainStimulation #SleepScience #Neuroscience #EEG #ClinicalTrials #SleepResearch #HealthcareInnovation

How does deep brain stimulation affect sleep structure and timing in patients? Dr Joram van Rheede discusses the importance of slow-wave activity in deep sleep for memory consolidation and metabolic processes. Data from deep brain stimulation (DBS) devices show that, before DBS, patients often experience deep sleep later in the night. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #SleepScience #DeepBrainStimulation #Neuroscience #SleepDisorders #MentalHealth #EEG #ClinicalResearch

What recent advancements have been made in identifying biomarkers for Deep Brain Stimulation therapy in major depressive disorder? Dr Joram van Rheede from the University of Oxford discusses the use of DBS for major depressive disorder (MDD) as an emerging field, with experimental therapy targeting the subcallosal cingulate gyrus—a key region in mood regulation. He also mentions the recent research aimed to identify a biomarker to help DBS systems adapt to individual patient needs. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #DeepBrainStimulation #MajorDepressiveDisorder #Neuroscience #MentalHealthInnovation #Biomarkers #AIinHealthcare #SleepResearch

What are the implications of deep brain stimulation on the brain's master clock and circadian rhythms? Dr Joram van Rheede explains that deep brain stimulation (DBS) interacts with the brain's master clock, the suprachiasmatic nucleus (SCN), which regulates circadian rhythms, body temperature, and other physiological processes. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #CircadianRhythms #DeepBrainStimulation #Neuroscience #BrainHealth #MedicalDevices #SleepScience #HealthcareInnovation

Tremor affects about 2 percent of the global population and is immensely disabling, preventing individuals from eating, drinking and dressing in extreme forms. It is super-gratifying, therefore, to see that Machine Medicine's novel pixel-based, deep-learning approach to tremor severity estimation accurately tracks changes in symptom severity in multiple different treatment conditions, in both direction and magnitude (compared to specialist movement disorder clinicians). ArXiv preprint available here: https://lnkd.in/e3GiJQWA Comments and suggested improvements welcome! And congrats to our data science team, and especially first author Felipe Duque Quiceno, for this superb piece of work.

How do long-term changes in brain dynamics and the sleep-wake transition impact the effectiveness of DBS systems? Dr Joram van Rheede from the University of Oxford discusses the impact of long-term changes in brain dynamics, focusing on differences between waking and sleeping states. Waking brain activity is characterized by fast, low-amplitude signals, while sleep shows larger, slower waves. This transition suggests that brain function varies significantly between day and night. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #BrainDynamics #DeepBrainStimulation #Neuroscience #ParkinsonsDisease #SleepResearch #MedicalDevices #HealthcareInnovation

What does the Good Regulator Theorem imply about the dynamics of the brain in DBS systems? Dr Joram van Rheede from the University of Oxford explains the "Good Regulator Theorem," which states that an effective regulator must contain a model of the system it regulates. When applied to deep brain stimulation (DBS), understanding the dynamics of biomarkers is crucial. Dr. Joram emphasizes that traditional research, often conducted during the day, may overlook how biomarkers respond to stimulation over longer time scales, which is essential for effective therapy. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #Neuroscience #DeepBrainStimulation #Cybernetics #Biomarkers #HealthcareInnovation #CircadianRhythms #MedicalResearch

How can Deep Brain Stimulation be optimized to manage neurological conditions? Dr Joram van Rheede from the University of Oxford discusses how DBS helps control symptoms by modulating abnormal brain activity. Traditionally, clinicians manually adjust the stimulation, but this method can be inefficient. He highlights the advancements in closed-loop DBS systems, which automatically adjust stimulation in real-time based on brain activity, improving the precision and effectiveness of the treatment. Identifying biomarkers is key to optimizing this therapy. You can watch the whole video here:  https://lnkd.in/eyxiv5w9 #Neuroscience #MedTech #HealthcareInnovation #BrainHealth #MedicalTechnology #Neurology

How can Bayesian analysis improve the inferential framework in cognitive science and psychology compared to traditional significance testing? Dr. Conor Houghton advocates for Bayesian analysis in cognitive science and psychology, critiquing the reliance on traditional significance testing and the replication crisis in psychology experiments. You can watch the whole video here:  https://lnkd.in/d8fk3rjX #BayesianAnalysis #CognitiveScience #Psychology #ReplicationCrisis #StatisticsInScience #DataAnalysis #ScientificMethod #MachineLearning