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Co-Founder, CEO & CSO at Bastion Therapeutics | Immunology | Cell Therapy | Autoimmunity | Oncology | Inflammation | Life Science Consulting
🔬 The intimate relationship between the epithelium and the immune system is essential for maintaining tissue #homeostasis. When this delicate balance is disrupted, it can lead to #autoimmunediseases and #cancer. While stem cell-derived #organoids have become powerful models for studying epithelial function, they fall short of capturing the complete organ-level processes due to the absence of tissue-resident immune cells. 🧫 Introducing human intestinal immuno-organoids (IIOs)! These groundbreaking models are formed through the self-organisation of epithelial organoids and autologous tissue-resident memory T (TRM) cells. A portion of these TRM cells integrate within the epithelium, continuously surveying the barrier. This interaction is driven by TRM cell-enriched transcriptomic programs that govern cell motility and adhesion, offering a deeper understanding of immune surveillance at the epithelial level. 🧬 By combining IIOs with single-cell transcriptomics, researchers (Timothy Recaldin et al.) investigated the complex dynamics of intestinal #inflammation triggered by cancer-targeting biologics in patients. The study uncovered that inflammation led to the emergence of an activated CD8+ T cell population, acquiring intraepithelial and cytotoxic features over time. This process was preceded by a T helper-1-like CD4+ population that initially produced cytokines and later became cytotoxic. 💡 The versatility of IIOs, coupled with their ability to mimic real immune interactions, allowed researchers to identify the Rho pathway as a potential target for mitigating immunotherapy-associated intestinal inflammation. These findings highlight the potential of IIOs in studying tissue-resident immune responses in #tumorigenesis, #infections, and autoimmune diseases. 🤔 How do you think this innovative approach with IIOs could impact future research in autoimmune diseases or cancer treatment? --- 👋 Hi, I’m Nia! I’m passionate about exploring the latest advancements in #immunology, #therapeutics, #biotech, and #startups. If you’re as fascinated by the future of #healthcare as I am, hit that follow button for more insights, discussions, and cutting-edge news. Let’s stay connected and keep the conversation going! #ScientificResearch #Immunology #Organoids #CancerResearch #AutoimmuneDiseases #Biotech #Innovation #HealthcareScience