The Lancet Group

🏳️⚧️March 31 is transgender day of visibility. Transgender, non-binary, and gender diverse (trans) people face a disproportionate and substantial burden of HIV. With multiple systemic factors contributing to risk of HIV acquisition and barriers to prevention, testing, and treatment. 🏳️⚧️The Lancet HIV has marked Transgender Day of Visibility by publishing a Personal View by Sari Reisner (University of Michigan, Ann Arbor, MI, USA) on the Situated Vulnerabilities and Resiliencies Framework, which describes and explains HIV inequities faced by trans populations. The framework highlights the need for integrated strategies and interventions that are neutral to HIV status and grounded in health and human rights, work with trans communities, and use strengths-based approaches leveraging situated resiliencies to reduce pervasive stigma and advance HIV equity in trans populations. 📰 Read the Personal View here https://lnkd.in/erkntBwK 🏳️⚧️We also publish research from Reisner and colleagues reporting data from the LEGACY cohort: the study shows that gender-affirming care is important for optimising HIV outcomes among trans people. Trans people receiving gender-affirming hormone therapy in this study had 37% lower risk of HIV acquisition and 44% lower risk of viral non-suppression compared with those not receiving hormone therapy. 📰 Read the research here: https://lnkd.in/eCNb3JFU 🎧 In our March podcast, Sari Reisner joins us to discuss his work: https://lnkd.in/eV_raRBw 🏳️⚧️It is essential to recognise trans men and women, non-binary, and gender-diverse populations in the HIV response. Providing social and medical support for trans people to access stigma-free gender-affirming care is essential to ensuring positive HIV outcomes. On Transgender Day of Visibility, we express our support and allyship to trans communities. #tdov #transdayofvisibility #transgender #trans #lgbtq #transgenderdayofvisibility #HIV #publichealth #globalhealth #humanrights

💬 "Uneven and Disappointing" Despite their proven effectiveness, uptake of WHO best buys for combating non-communicable diseases (NCDs) has been uneven and disappointing, as highlighted by the authors of a new Health Policy in The Lancet Regional Health – Europe. However, a range of "quick buys" could drive measurable public health impacts within just five years ✅ After evaluating 49 cost-effective interventions (each costing less than $120,000 per disability-adjusted life-year averted), 25 were identified as quick buys, including those relating to: 🔹 Tobacco (5 interventions) 🔹 Alcohol (4 interventions) 🔹 Unhealthy diet (3 interventions) 🔹 Physical inactivity (1 intervention) 🔹 Cardiovascular disease (3 interventions) 🔹 Diabetes (4 interventions) 🔹 Chronic respiratory disease (1 intervention) 🔹 Cancer (4 interventions) According to Gauden Galea and colleagues, “These findings not only provide valuable guidance for policymakers navigating short-term political cycles but also have the potential to accelerate progress toward global health targets.” Discover the full set of interventions here ➡️ https://hubs.ly/Q03f2XnQ0 Alt: Left, the first page of the Health Policy. Right, Lancet editor Heather Brown speaks at the WHO/Europe launch of the Health Policy.

🔔 We are pleased to announce The Lancet Obstetrics, Gynaecology, & Women’s Health! ⬇️

Lancet weekly highlights ✨ 1️⃣ Almost 40 years ago, the discovery of the vasoactive neuropeptide calcitonin gene-related peptide (CGRP) and its role in migraine pathophysiology ushered in a new era in migraine treatment. Since 2018, monoclonal antibodies (mAbs) targeting the CGRP pathway are available for migraine prevention. What next? On the cover of The Lancet, a Therapeutics paper. 🔗 https://hubs.li/Q03cTyL50 2️⃣ “The sweeping chaotic and ill-considered unilateral halt of global health programmes is no way to institute reforms.” Our editors discuss the demise of USAID and rethinking foreign aid in a turbulent climate. Read a new Editorial. 🔗 https://hubs.li/Q03cTyL50 3️⃣ After a series of senior departures from NHS England, the UK Prime Minister has caused shockwaves by abolishing the body entirely, Jacqui Thornton reports. 🔗 https://hubs.li/Q03cTyrF0 📘 Find this content and more in the March 22 issue of The Lancet: https://hubs.li/Q03cTwSJ0 Alt: Cover of The Lancet, March 22 issue. The cover quote says, “Drugs targeting the CGRP pathway represent a mechanism-specific approach to both acute and preventive migraine treatment with a proven efficacy and an excellent safety and tolerability profile.”

How can we reduce the burden of non-communicable diseases (NCDs) in the most cost-effective way? Today, we at WHO Regional Office for Europe presented 25 specific public health measures – quick buys – that can improve people’s health within in a single political cycle. Co-authored by WHO/Europe’s NCD experts, a new paper in The Lancet Group Regional Health - Europe shows how targeted actions can have a positive impact on population health across Europe and Central Asia in as little as 5 years. The 25 quick buys include policies targeting key risk factors, including tobacco, alcohol, unhealthy diets, and physical inactivity, as well as disease groups, such as cardiovascular diseases, diabetes, chronic respiratory diseases, and cancers. NCDs take a massive toll on lives and economies. In our Region, they account for 90% of all deaths and 85% of disability, including mental ill health. This is why addressing NCDs is a core pillar of the Second European Programme of Work - #EPW2. Ultimately, health is a political choice. We hope this study, with its clear findings, will help the governments and policymakers take bold actions to prevent and respond to the scourge of NCDs – securing better health for generations to come. The paper is available here >> https://bit.ly/4hN8aqA #HealthForAll WHO Regional Office for Europe | World Health Organization | Gauden Galea | Allison Ekberg Dvaladze | David Stuckler | Kremlin Wickramasinghe | Erkin Checheibaev | Martin McKee | Lela Sturua | Svetlana Cotelea-Nicolaescu | Aurelijus Veryga | Benedetta Armocida | Hanna Tolonen | Miranda W.

🗺️Today is World Tuberculosis Day, marking the anniversary of the discovery of Mycobacterium tuberculosis by Dr Robert Koch in 1882. In 2023, tuberculosis once again became the leading cause of death from an infectious disease. In 2023, an estimated 10·8 million people fell ill with tuberculosis worldwide, and 1·25 million people died of tuberculosis. Globally, an estimated 400000 people developed multidrug-resistant or rifampicin-resistant tuberculosis. With ongoing challenges, such as the recent termination of life saving tuberculosis treatment programmes by the Trump administration and possible future challenges, it is imperative to highlight the impact of tuberculosis and do everything possible to realise a tuberculosis-free world. 🗞️ The Lancet Infectious Diseases has published new tuberculosis content for #WorldTBDay. 🆕 Personal View ‘Tuberculosis preventive therapy: scientific and ethical considerations for trials of ultra-short regimens’ by Timothy Walker and colleagues. In this personal view, authors discuss scientific and ethical considerations around the investigation of ultra-short-course preventive therapy for tuberculosis. The full personal view can be found here:  https://bit.ly/4hHvENI 📰News ‘Tuberculosis groups struggle with loss of US funding’ reported by Ed Holt The news piece can be found here: https://bit.ly/4bZoMtM 📝Correspondence ‘Threat of HIV and tuberculosis drug resistance after US funding cuts’ by Max McClure and Monica Gandhi Read more here: https://bit.ly/4c1Krlc 🪪Profile Profile of rovina ruslami by Tony Kirby Read more here: https://bit.ly/4iWCNuE #EndTB

🌐 Today is World Tuberculosis Day, marking the anniversary of the discovery of Mycobacterium tuberculosis by Dr Robert Koch in 1882. TB remains the leading cause of death from an infectious disease.  🧪 The Lancet Respiratory Medicine has some special content, published today and freely available to all, to highlight the devastating impact of TB disease and the urgent need to work towards ending TB. 📰 News End of #USAID leaves enormous funding shortfall for TB by Talha Burki https://lnkd.in/e3PdRXzY 📜 Comments Unveiling a hidden phenotype of early #tuberculosis https://lnkd.in/eisyGu4A Addressing the growing TB disease burden in England https://lnkd.in/ee6fXNZE   The importance of post-tuberculosis morbidity in high-income countries https://lnkd.in/epRS76c5 Equitable, personalised medicine for tuberculosis: treating patients, not diseases https://lnkd.in/evpbQKyx 📚 Review Post-tuberculosis lung disease: towards prevention, diagnosis, and care https://lnkd.in/eSQwd-QM 🙏 Massive thanks to all our authors for their work in this area Joanna Ehrlich Clara Suñer Navarro Gavin Churchyard Frank Cobelens South African Tuberculosis Vaccine Initiative (SATVI) Tom Wingfield Manish Pareek Lorenzo Guglielmetti Samiran Panda Carole Mitnick Dr Rebecca Nightingale Leonardo Martinez Daire Cantillon Beate Ringwald Jamillah Meghji Celso Khosa Andrea Rachow Neelima Navuluri Samara Barnes Refiloe Masekela Gregory Bisson Sara Auld Amanzhan Abubakirov Ailva O'Reilly #EndTB

When a person is diagnosed with tuberculosis, one of their first questions is often, “Why did I get tuberculosis? Why me?” A diagnosis of tuberculosis can be overwhelming. In The Lancet, a new Seminar spotlights what health-care providers can do to ✅ Respond appropriately and effectively to patients’ concerns ✅ Identify people who are at risk or are affected by tuberculosis ✅ Promptly initiate rapid and accurate investigations, then offering effective preventive or curative treatment with adequate support -- including after successful completion of treatment Tuberculosis remains a leading cause of death globally, with ongoing and emerging challenges threatening the strong movement to eliminate the disease. Read the Seminar in full ➡️ https://hubs.li/Q03cTsrm0 Images below based on a figure in the paper illustrating risk factors and main clinical characteristics of tuberculosis infection and disease. #WorldTBDay #EndTB

📢 Measles is resurging, not just in the USA. 57 countries in 2023 saw large and disruptive measles outbreaks, which is an increase of 58% compared to 2022, and almost half of all outbreaks were in Africa. The MMR vaccine is highly effective with 93% protection after one dose and 97% after a second. However, under-vaccination for measles is increasing and this is driven by various factors, such as vaccine misinformation, lack of access to vaccination, or conflict. 💡In a recent comment- ‘Measles in Texas: waning vaccination and a stark warning for public health’, Trish Perl and Krutika K. discuss how declining vaccination rates are driving the resurgence of measles and warn that without urgent action, more preventable diseases will follow. Read the full comment here: https://bit.ly/4hDMg9a 💡Our recent editorial ‘Facts and myths about measles’ highlights that knowing the facts about measles information and disinformation is key for measles control. Quote: ‘Infectious disease specialists have a role in pointing out the high rates of complications of measles infection and questioning the motivations of antivaccine activists.’ Read the editorial here:  bit.ly/4bMMaus #Measles, #MMR, #disinformation, #outbreaks

Exposure to household air pollution remains a leading global risk factor, contributing considerably to the burden of disease ❌ This is despite decreased use of solid fuels for cooking 📉 A new paper in The Lancet estimates 2.67 billion people—just over a third of the global population—were exposed to household air pollution (HAP) from all sources at a mean concentration of 84·2 μg/m3 in 2021. While these figures suggest a notable reduction in the percentage of the global population exposed in 1990, in absolute terms, there has been only a decline of 0.35 billion (10%) from the 3.02 billion people exposed to HAP in 1990. Action on HAP has the potential to improve the quality of life and health outcomes for millions of people ✅ Explore how these new estimates could help health policy makers and practitioners precisely target and tailor health interventions ➡️ https://hubs.li/Q03cGkzP0 Figure: Percentage of global population exposed to HAP from solid cooking fuels, 2021