An exciting opportunity for a post-doctoral research associate
We are looking for a post-doctoral research associate to work on our Wellcome Trust funded addiction programme looking for novel ways of combating the opioid crisis. The research will be conducted @University of Glasgow Advanced Research Centre (ARC) @University of Glasgow in close collaboration with Dr Carrie Jones @Warren Centre for Neuroscience Drug Discovery @Vanderbilt University. This post, will investigate molecular mechanisms that can prevent opioid misuse and opioid-use-disorder and hence have a major impact on the global opioid crisis. In exciting breakthrough studies, we have discovered that inhibition of the M5 muscarinic acetylcholine receptor (M5-receptor) can prevent opioid drug seeking and reduce cue-induced relapse. The implications of our findings are huge. They indicate that by co-administration of a drug that inhibits the M5-receptor with opioid analgesics we can reduce the likelihood of patients becoming addicted to opioids and for those patients in remission from opioid addiction we can reduce the likelihood of relapse. This project will work in close collaboration with leading in vivo pharmacologist Dr. Carrie Jones, Vanderbilt University, Nashville USA, to understand fundamental aspects of M5-receptor biology and optimise ligands that can modulate M5-receptor activity to reduce the risk of opioid-addiction whilst retaining the drug’s analgesic properties. As part of a multi-disciplinary team, you will generate novel genetically engineered mice that will be used in combination with unique tool ligands in conjunction with anatomical, behavioural and molecular biology-based studies to explore how M5-receptors regulate reward-seek pathways associated with drug-addiction and validate the potential of this G protein-coupled receptor (GPCR) as a therapeutic target. This is an opportunity for a highly motivated Research Scientist to conduct basic research with potential for pre-clinical translation. The candidate will be responsible for mapping the neuroanatomy of M5-receptor in the brain, pharmacological characterisation and in vitro and in vivo testing of novel agonists/ antagonists to M5-receptor and pre-clinical addiction studies to validate the M5-receptor as a target in the treatment of addiction. The candidate will be based at University of Glasgow in state-of-the-art laboratories located in the newly built Advanced Research Centre (ARC) in the heart of the University campus and have the opportunity to spend time in our collaborator’s lab in Nashville, Tennessee. Informal enquiries may be directed to Professor Andrew Tobin, Andrew.Tobin@glasgow.ac.uk This post is full time and has funding until 30th September 2029 To apply online at: https://lnkd.in/gESncnt9