Altis Biosystems

Altis Biosystems

Biotechnology

Durham, NC 5,215 followers

Capturing the Complexity of the Human Gut

About us

Altis’ mission is to provide scientific innovation, through collaborative relationships, by helping companies develop safer and more effective therapies to treat patients suffering from human disease. We support life science researchers by providing expertise and unique in vitro platforms to further their research and increase their understanding of human biology, while reducing the need for animal testing. Altis Biosystems has pioneered the creation of Repligut® Systems, a collection of in vitro models derived from stem cells and designed specifically for pre-clinical drug discovery. These innovative systems overcome the constraints of conventional cell lines and animal models, providing a highly accurate representation of human intestinal physiology. Our flagship RepliGut® Planar models advance novel pharmaceuticals by harnessing the potential of human donor intestinal stem cells. These cells undergo a process of sequential proliferation and differentiation, ultimately transforming into the essential cell types found in the human gastrointestinal epithelium for use in drug discovery and development. Our RepliGut® Models, which accurately replicate the complex cellular lifecycle of the intestinal crypt, provide an exceptional platform for numerous applications. Derived from various regions of the intestine, they allow for compound screening, disease modeling, drug disposition analysis, toxicity assessments, efficacy studies, and fundamental research investigations. With their human-derived physiologically-relevant capabilities, our models have the power to vastly reduce the dependence on animal studies, in line with the transforming landscape of pre-clinical drug discovery.

Industry
Biotechnology
Company size
11-50 employees
Headquarters
Durham, NC
Type
Privately Held
Founded
2015
Specialties
Drug Discovery, Biotechnology, Pharmacology, Contract Research, Innovation, DMPK, ADME, Toxicology, Inflammation, and Start-up

Locations

  • Primary

    6 Davis Drive

    Suite 500/PO Box 12878

    Durham, NC 27709, US

    Get directions

Employees at Altis Biosystems

Updates

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    5,215 followers

    💡More than one-third of patients receiving chemotherapy treatment will experience severe diarrhea. Chemotherapeutic agents often target actively proliferating cells. During preclinical studies, drug- induced toxicity may go undetected in differentiated cell models that lack this cell population. In our latest preprint, we show that anti-mitotic drugs afatinib and colchicine are cytotoxic to proliferative cells while sparing differentiated cells. Read more about how our primary stem-cell based assay can predict drug-induced toxicity with up to 90% accuracy. https://hubs.ly/Q02VDNvY0

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  • View organization page for Altis Biosystems, graphic

    5,215 followers

    A stem cell begins its journey at the base of the intestinal crypt, continuously dividing to produce new cells. As the stem cell differentiates, it gives rise to transit amplifying cells that proliferate and gradually differentiate into specialized cell types, such as enterocytes, goblet cells, and enteroendocrine cells. This constant turnover drives cell migration along the epithelial layer. During this ascent, the cells mature and take on their specific functions, such as nutrient absorption or mucus secretion. At the top of the crypt, the fully differentiated cells are shed into the intestinal lumen, contributing to the gut's overall functionality and integrity. This process is crucial for maintaining a healthy intestinal barrier and ensuring efficient nutrient absorption. 💡It's essential to utilize models that accurately replicate the intestinal crypt environment, as they better simulate the complex interactions between cell types. Discover the versatility of our RepliGut® Technology and find out how it can accelerate your drug discovery programs: https://hubs.ly/Q02V8N4M0

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  • View organization page for Altis Biosystems, graphic

    5,215 followers

    Intestinal mucus is an important mediator of bacterial interactions, enabling both beneficial and harmful microbes to thrive and compete within the host. 🦠 Altis now offers RepliGut® Mucus produced by primary human intestinal epithelial cells. 📖Read about how RepliGut® Mucus can be used to study bacterial interactions: https://hubs.ly/Q02SLbrD0 Contact us today to learn more or obtain a quote: https://hubs.ly/Q02SLbHx0

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  • View organization page for Altis Biosystems, graphic

    5,215 followers

    Congratulations to Nancy Allbritton, Altis co-founder, on her induction to the National Academy of Engineering this past weekend. This is a prestigious honor and a testament to her remarkable work in the field. This recognition highlights her innovative contributions to technologies like single-cell analysis and gut-on-chip platforms for drug screening, and her impact on engineering education. The Altis team is inspired by her achievements and excited to see how her continued innovations will shape the future of biotechnology. https://hubs.ly/Q02Rll7r0

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Funding

Altis Biosystems 7 total rounds

Last Round

Series A
See more info on crunchbase