Altis Biosystems

RepliGut® Models mimic in vivo responses to support a variety of research and pharmacological applications. Explore RepliGut® applications: https://hubs.ly/Q02V-_NJ0

💡More than one-third of patients receiving chemotherapy treatment will experience severe diarrhea. Chemotherapeutic agents often target actively proliferating cells. During preclinical studies, drug- induced toxicity may go undetected in differentiated cell models that lack this cell population. In our latest preprint, we show that anti-mitotic drugs afatinib and colchicine are cytotoxic to proliferative cells while sparing differentiated cells. Read more about how our primary stem-cell based assay can predict drug-induced toxicity with up to 90% accuracy. https://hubs.ly/Q02VDNvY0

RepliGut® StemTox is a rapid and robust assay to predict drug-induced gastrointestinal toxicity in a 96-well plate. Read our latest preprint to find out how this assay detects potential adverse effects before human trials https://hubs.ly/Q02VsBL30

A stem cell begins its journey at the base of the intestinal crypt, continuously dividing to produce new cells. As the stem cell differentiates, it gives rise to transit amplifying cells that proliferate and gradually differentiate into specialized cell types, such as enterocytes, goblet cells, and enteroendocrine cells. This constant turnover drives cell migration along the epithelial layer. During this ascent, the cells mature and take on their specific functions, such as nutrient absorption or mucus secretion. At the top of the crypt, the fully differentiated cells are shed into the intestinal lumen, contributing to the gut's overall functionality and integrity. This process is crucial for maintaining a healthy intestinal barrier and ensuring efficient nutrient absorption. 💡It's essential to utilize models that accurately replicate the intestinal crypt environment, as they better simulate the complex interactions between cell types. Discover the versatility of our RepliGut® Technology and find out how it can accelerate your drug discovery programs: https://hubs.ly/Q02V8N4M0

One of the standout features of our RepliGut® technology is its innovative approach to drug testing. The sequential proliferation and differentiation phases enable researchers to independently explore drug effects on both proliferative and fully differentiated intestinal epithelial cells. Visit our website for more details: https://hubs.ly/Q02TP3GJ0

Intestinal mucus is an important mediator of bacterial interactions, enabling both beneficial and harmful microbes to thrive and compete within the host. 🦠 Altis now offers RepliGut® Mucus produced by primary human intestinal epithelial cells. 📖Read about how RepliGut® Mucus can be used to study bacterial interactions: https://hubs.ly/Q02SLbrD0 Contact us today to learn more or obtain a quote: https://hubs.ly/Q02SLbHx0

❓Curious about how RepliGut® technology can elevate your research program? We're here to help! Connect with our expert scientists to design a fully customized protocol tailored to your specific research needs. Your research goals are within reach—let's make it happen! 💡 Contact us➡️ https://hubs.ly/Q02SmQv60

🌐Our epithelial stem cell biobank includes six distinct regions of the intestine. With our innovative RepliGut® technology, you can conduct drug safety, efficacy, and absorption studies across multiple intestinal regions and diverse human donors. 💊 🔓Unlock new insights into gastrointestinal health! https://hubs.ly/Q02S23H_0

Congratulations to Nancy Allbritton, Altis co-founder, on her induction to the National Academy of Engineering this past weekend. This is a prestigious honor and a testament to her remarkable work in the field. This recognition highlights her innovative contributions to technologies like single-cell analysis and gut-on-chip platforms for drug screening, and her impact on engineering education. The Altis team is inspired by her achievements and excited to see how her continued innovations will shape the future of biotechnology. https://hubs.ly/Q02Rll7r0

We're #hiring a new Research Scientist I, Project Lead in Durham, North Carolina. Apply today or share this post with your network!