BioModels

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In vitro and ex vivo analyses are important components of a complete preclinical program. Whether intended to complement an existing in vivo project or indicated as standalone experiments, 𝗕𝗶𝗼𝗠𝗼𝗱𝗲𝗹𝘀 𝗵𝗮𝘀 𝘁𝗵𝗲 𝘁𝗼𝗼𝗹𝘀 𝗮𝗻𝗱 𝗲𝘅𝗽𝗲𝗿𝘁𝗶𝘀𝗲 𝘁𝗼 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝗱𝗮𝘁𝗮 𝘁𝗵𝗮𝘁 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗲𝗳𝗳𝗶𝗰𝗮𝗰𝘆 𝗮𝗻𝗱 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝗼𝗳 𝗮𝗰𝘁𝗶𝗼𝗻 𝘀𝘁𝘂𝗱𝗶𝗲𝘀. If you’d like to start a conversation and discuss how we can help support your program goals, please contact Ashlee Graham directly!

Interested in evaluating your therapeutic in a preclinical model of GVHD? Assess your experimental materials for efficacy and mechanism of action in our established rodent models. 𝘉𝘪𝘰𝘔𝘰𝘥𝘦𝘭𝘴' 𝘎𝘝𝘏𝘋 𝘮𝘰𝘥𝘦𝘭𝘴 𝘢𝘭𝘭𝘰𝘸 𝘺𝘰𝘶 𝘵𝘰 𝘦𝘷𝘢𝘭𝘶𝘢𝘵𝘦 𝘵𝘩𝘦 𝘪𝘮𝘮𝘶𝘯𝘰𝘱𝘢𝘵𝘩𝘰𝘭𝘰𝘨𝘺 𝘰𝘧 𝘱𝘰𝘴𝘵-𝘵𝘳𝘢𝘯𝘴𝘱𝘭𝘢𝘯𝘵 𝘥𝘪𝘴𝘦𝘢𝘴𝘦 𝘪𝘯 𝘷𝘢𝘳𝘪𝘰𝘶𝘴 𝘰𝘳𝘨𝘢𝘯𝘴 𝘴𝘶𝘤𝘩 𝘢𝘴 𝘴𝘬𝘪𝘯, 𝘨𝘶𝘵, 𝘭𝘪𝘷𝘦𝘳, 𝘢𝘯𝘥 𝘭𝘶𝘯𝘨. 𝗧𝗵𝗲 𝗕𝗶𝗼𝗠𝗼𝗱𝗲𝗹𝘀 𝘁𝗲𝗮𝗺 𝗶𝘀 𝗲𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲𝗱 𝘄𝗶𝘁𝗵 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲 𝗚𝗩𝗛𝗗 𝗺𝗼𝗱𝗲𝗹 𝗶𝗻𝗱𝘂𝗰𝘁𝗶𝗼𝗻 𝗽𝗮𝗿𝗮𝗱𝗶𝗴𝗺𝘀: • Acute GVHD (Major MHC Mismatch) • Sclerodermatous Chronic GVHD (Minor MHC Mismatch) • Humanized GVHD (PBMC Xenograft- xGVHD) • Graft vs Leukemia (GVL) Below please find data on our acute GVHD model. For additional information on our other models and/or to discuss your study needs, please contact Ashlee Graham directly. We look forward to connecting! 

Targeting the September 5th deadline for your NIH SBIR grant submission? 𝗔𝘀 𝗮 𝗳𝘂𝗹𝗹 𝘀𝗲𝗿𝘃𝗶𝗰𝗲 𝗽𝗿𝗲𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗖𝗥𝗢, 𝘁𝗵𝗲 𝗕𝗶𝗼𝗠𝗼𝗱𝗲𝗹𝘀 𝘁𝗲𝗮𝗺 𝘄𝗲𝗹𝗰𝗼𝗺𝗲𝘀 𝘁𝗵𝗲 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝘁𝗼 𝘀𝗲𝗿𝘃𝗲 𝗮𝘀 𝗮 𝘀𝘂𝗯-𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗼𝗿 𝗳𝗼𝗿 𝘆𝗼𝘂𝗿 𝗮𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻. We’ll provide: • study designs and quotes reflective of the experiments you have in mind • corresponding documentation such as letter of support, facilities description, and anything else you may need We’re happy to revise designs/estimates based on reviewer feedback, and when awarded, we’ll look forward to working together. Visit www.BioModels.com and fill out the contact us form at the bottom of the page to learn more!

Are you "𝘁𝗵𝗶𝗻𝗸𝗶𝗻𝗴 𝗼𝘂𝘁𝘀𝗶𝗱𝗲 𝘁𝗵𝗲 𝗯𝗼𝘅” for your next preclinical study? At BioModels, we understand that not every preclinical program has a clearly defined path to IND. Sometimes projects require creative scientific thinking and model development to deliver the solutions needed to advance your asset. 𝗕𝗶𝗼𝗠𝗼𝗱𝗲𝗹𝘀 𝘀𝗽𝗲𝗰𝗶𝗮𝗹𝗶𝘇𝗲𝘀 𝗶𝗻 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗻𝗴 𝘁𝗼 𝗱𝗲𝘃𝗲𝗹𝗼𝗽 𝗰𝘂𝘀𝘁𝗼𝗺𝗶𝘇𝗲𝗱 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀. Whether you’re interested in… • Proof-of-concept experiments designed to validate novel targets • Approaches that have been described in the literature • The ability to model disease indications for which the current animal models are insufficient or do not exist …𝘁𝗵𝗲 𝗕𝗶𝗼𝗠𝗼𝗱𝗲𝗹𝘀 𝘁𝗲𝗮𝗺 𝗶𝘀 𝗵𝗲𝗿𝗲 𝘁𝗼 𝗯𝗿𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝗶𝗱𝗲𝗮 𝗳𝗿𝗼𝗺 𝗰𝗼𝗻𝗰𝗲𝗽𝘁 𝘁𝗼 𝗰𝗼𝗺𝗽𝗹𝗲𝘁𝗶𝗼𝗻. Visit www.BioModels.com and fill out the contact us form at the bottom of the page to start the conversation! 

Another successful Microbiome Movement with Hanson Wade Group! Caitlin SL Parello Olivia Grillo

With an increasing need for translational preclinical NAFLD, NASH, and liver fibrosis models, BioModels is pleased to share our recent validation data from the amylin liver NASH (AMLN) model.  This model recapitulates many features of human disease, including steatosis and fibrosis. BioModels is ready to help you assess your therapeutic for the treatment of this extremely prevalent disease.   From an initial consultation to better understand the disease model and develop a study design, through study execution and data reporting/interpretation, BioModels is here to be your partner every step of the way. For additional AMLN NASH model information and representative data, please visit our website at www.biomodels.com. If you’d like to start a conversation and discuss how we can help support your program goals, please contact Ashlee Graham directly.

Another successful oral presentation and poster by our Associate Director, Caitlin SL Parello! We teamed up with Taconic Biosciences and Dallas Tissue Research to present “Validation of a Microbiome Dependent Colitis Model via Fecal Microbial Transplant in Germ-Free IL-10 Deficient Mice” If you’d like to receive a copy of the poster or presentation slide deck please send an email to info@biomodels.com or message Ashlee Graham on LinkedIn and we’ll send it right over!

We’re ready to meet and connect at IMMUNOLOGY2024! Stop by BioModels booth #407 to learn more with Caitlin SL Parello, Andrew Borkowski and Ashlee Graham ! #aai2024 #immunology2024

In case you missed it, we shared some big news - www.biomodels.com has a fresh new look! 𝑂𝑢𝑟 𝑛𝑒𝑤 𝑤𝑒𝑏𝑠𝑖𝑡𝑒 𝑖𝑠 𝑛𝑜𝑤 𝑙𝑖𝑣𝑒 𝑎𝑛𝑑 𝑟𝑒𝑎𝑑𝑦 𝑓𝑜𝑟 𝑦𝑜𝑢 𝑡𝑜 𝑑𝑖𝑠𝑐𝑜𝑣𝑒𝑟 ℎ𝑜𝑤 𝑜𝑢𝑟 𝑡𝑎𝑖𝑙𝑜𝑟𝑒𝑑 𝑠𝑒𝑟𝑣𝑖𝑐𝑒𝑠 𝑎𝑛𝑑 𝑒𝑥𝑝𝑎𝑛𝑑𝑖𝑛𝑔 𝑐𝑎𝑝𝑎𝑏𝑖𝑙𝑖𝑡𝑖𝑒𝑠 𝑐𝑎𝑛 𝑠𝑢𝑝𝑝𝑜𝑟𝑡 𝑦𝑜𝑢𝑟 𝑝𝑟𝑒𝑐𝑙𝑖𝑛𝑖𝑐𝑎𝑙 𝑟𝑒𝑠𝑒𝑎𝑟𝑐ℎ 𝑔𝑜𝑎𝑙𝑠 𝑎𝑛𝑑 𝑑𝑟𝑖𝑣𝑒 𝑖𝑛𝑛𝑜𝑣𝑎𝑡𝑖𝑜𝑛. Have questions or want to explore a potential collaboration? Check out our new website and fill out the contact us form to get started! Thank you for being part of the BioModels community!