Broad Clinical Labs

Broad Clinical Labs is excited to formally announce our work with Genomes2Veterans (G2V) Research Program, which will use our BCL developed Blended Genome Exome (BGE) technology to return genomic risks for prostate cancer to Veteran(s) who enroll in the trial. BCL is delighted to have worked with the team at Veterans Affairs to validate and launch this new pipeline and we look forward to delivering results to participants very soon!

Delve into the accuracy of Whole Genome Sequencing (WGS) for clinical testing with us at #ASHG2024! Join Michael Gatzen as he presents "Orthogonal validation of sequencing in the clinical setting: Lessons from assessing concordance between whole genome sequencing and genotyping arrays with 133,000 samples" at the Omics Technologies Poster Session, Board 1161T, on Thursday, Nov. 7, 2024, from 2:30–4:30pm. Read more here: https://bit.ly/3NCtkel #WGS #ClinicalTesting #GeneticTesting #AllOfUs #Research

Join our partner as they discuss their latest science and showcase their solutions to your clinical needs! Industry Education Session Presented by Fabric Genomics: Best of both worlds: monogenic and polygenic analysis built on the backbone of clinical genetic disease testing. Thu, Nov 07 - Room 108 12:00pm–1:00pm Speakers: • Samuel Strom, PhD FACMG; VP Clinical Operations and Clinical Genomics at Fabric Genomics • Robert Green, MD MPH; Professor of Medicine (Genetics) at Harvard Medical School • Francisco M. De La Vega, PhD; Chief Technology Officer at Galatea Bio • Niall J Lennon, PhD; CSO and Chair at Broad Clinical Labs #ASHG2024 #BroadClinicalLabs #NGS #ClinicalSequencing #DiseaseTesting

Join us to hear from Steve Barnard about the latest Illumina innovations from Library Prep, Sequencing, and Analysis and learn how we are enabling transformative applications using Multiomics. Niall J Lennon from Broad Clinical Labs will join Steve to provide insights into new Illumina technology. Industry Education Session Presented by Illumina: Illumina Innovation Roadmap Wed, Nov 06 - Room 109 12:00pm–1:00pm #ASHG2024 #BroadClinicalLabs #NGS #Sequencing #Multiomics

Precision medicine in action at #ASHG2024: Prostate cancer risk prediction Join Dr. Jason Vassy as he presents the P-CARE model, a clinical prostate cancer risk prediction model that has been translated into a blended genome-exome (BGE) clinical assay now being deployed in a clinical trial. Model features: • Integrates polygenic score, family history, and genetic ancestry • Identifies individuals at higher and lower risk of prostate cancer • Developed in a biobank-linked healthcare system Clinical impact: • Moving away from one-size-fits-all approach • Precision prevention and early detection • Now being implemented in a VA randomized clinical trial (NCT05926102) "Translating genomic risk models to clinical trials in a learning health system: the Prostate CAncer integrated Risk Evaluation (P-CARE) model" Wednesday, November 6, 2024, 2:30–4:30pm Complex Traits and Polygenic Disorders Poster Session, Board 5171W Abstract: https://bit.ly/4eVRKLS #PrecisionMedicine #CancerPrevention #ASHG2024 #GenomicRisk #ClinicalTrials #ProstateCancer #BroadClinicalLabs

See our streamlined and sensitive assay for clinical diagnosis of neurological infections at #ASHG2024! Join Peter Trefry of Broad Clinical Labs as he presents a novel NGS-based assay for acute meningitis and encephalitis diagnosis developed in collaboration with Delve Bio. Key innovations include: • Pathogen-agnostic screening • Fully automated workflow • DNA and RNA sequencing • Rapid turnaround time Clinical impact: • Expanded pathogen detection • Reduced number of tests needed • Faster time to treatment • Overall cost reduction “Development and Scaling of a Sensitive NGS-based Assay for Clinical Diagnosis of Acute Meningitis and Encephalitis” Wednesday, November 6, 2024, 2:30–4:30pm Molecular and Cytogenetic Diagnostics Poster Session, Board 3050W Abstract: https://bit.ly/40lnl5e #GenomicMedicine #ClinicalDiagnostics #ASHG2024 #Neurology #PatientCare #InfectiousDisease #BroadClinicalLabs

Attention genomics enthusiasts! Don't miss Mark Fleharty's poster presentation at #ASHG24, "Best practices Terra workspace for processing PacBio long reads sequenced on the Revio™ system: Single sample, trio, and cohort modes”, at the Omics Technologies Poster Session, Board 1109W, on Wednesday, Nov. 6, 2024, from 2:30–4:30pm. Discover a cutting-edge WDL-based pipeline for processing long-read human WGS data from PacBio Revio™. Key steps of the workflow include: • Read preprocessing • Error correction • Alignment • Variant calling In addition, learn about an optional tertiary analysis step that includes advanced variant filtering by joint calling samples in either trio or cohort mode. Here’s the abstract for more information: https://bit.ly/4e7DDl7 #Genomics #LongReadSequencing #Bioinformatics #ASHG2024 #BroadClinicalLabs

See how we’re revolutionizing genomic screening at #ASHG24! Join Katie Larkin as she presents "Clinical blended genome exome (cBGE) for translational genomics" at the Omics Technologies Poster Session, Board 1121T, on Thursday, Nov. 7, 2024, from 2:30–4:30pm. Discover how cBGE combines genome-level SNV information (2x–3x coverage) with deep whole exome sequencing (>80x coverage) to yield a cost-effective approach for large-scale studies. This novel method could be a game-changer for: • CDC Tier 1 screening • Polygenic risk scores • Balancing clinical utility and cost Don't miss this opportunity to learn about the workflow and analytical validation performed to bring this clinical-level assay to BCL! Read more here: https://bit.ly/40eWAiL #GenomicMedicine #Bioinformatics #ASHG2024 #ResearchInnovation #BroadClinicalLabs

It’s almost time for the ASHG Annual Meeting in Denver, and we look forward to seeing you! Join us November 5–9, at booth #686, or at any of our four poster presentations, to discuss your research or clinical testing needs. Let’s explore how our comprehensive, scalable multi-omics services can support you at every phase of the precision medicine development pipeline. Our CLIA-certified and CAP-accredited laboratories also provide robust, routine clinical testing services to support healthcare providers everywhere. Email genomics@broadinstitute.org to schedule a time to connect with us at #ASHG2024. Learn more about our services here: https://bit.ly/4hdAmUt #ASHG2024 #ClinicalLaboratory #MultiomicsData #PrecisionMedicine #BroadClinicalLabs #BroadInstitute #DrugDiscovery #Genomics

BCL is happy to report that our flagship clinical whole genome process is now New York State approved. Read our blog post for more information!