Bruker Fluorescence Microscopy

These images of two-color hippocampal brain slices are AWESOME 👀 150um fixed hippocampus slices from mice transferred with retroviruses for Cre-T2A-EGFP or tdTomato. Taken with Bryan Luikart’s new Ultima 2Pplus multiphoton microscope installed at The University of Alabama Heersink School of Medicine. Enjoy your new system, we can’t wait to see what interesting research you perform with it in your lab! #neuroscience #brain #MicroscopyMonday

🎃 🍬 There’s many activities you can do around Halloween like carving pumpkins, passing out candy, or practicing your microscopy techniques! Bruker application scientist Kevin Mann got into the holiday spirit by creating this spooky graphic using the Ultima 2Pplus #optogenetics path. Freehanding results may vary 😅 Explore your creative side 👉 https://lnkd.in/dP5K8H96 #optogenetics #halloween

𝗦𝘂𝗽𝗲𝗿𝘃𝗶𝘀𝗲𝗱 𝗳𝗲𝗲𝗱𝗯𝗮𝗰𝗸 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗶𝘀 𝗴𝗿𝗲𝗮𝘁 𝗳𝗼𝗿 𝘁𝗶𝘀𝘀𝘂𝗲-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗶𝗻 𝗹𝗮𝗿𝗴𝗲 𝘀𝗽𝗲𝗰𝗶𝗺𝗲𝗻𝘀.   Read all about how Bruker’s Acquifer Imaging Machine (IM) and Plate-Viewer software provide a semi-automated approach for various experiments in our tech note “Supervised Feedback Microscopy with the Acquifer IM and Plate-Viewer.”   Semi-automated approaches offer a balance between software development time and project size, saving time and money. Check it out and see if this approach could benefit your lab’s screening projects. #data #analysis #microscopy 

“𝗧𝗵𝗲𝗿𝗲 𝘄𝗮𝘀 𝘀𝗼𝗺𝗲 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗶𝗻 𝘁𝗵𝗲 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱 𝘁𝗵𝗮𝘁 𝘄𝗮𝘀 𝗺𝗮𝘁𝘂𝗿𝗲 𝗲𝗻𝗼𝘂𝗴𝗵 𝗮𝗻𝗱 𝗰𝗼𝗻𝗻𝗲𝗰𝘁𝗲𝗱 𝗲𝗻𝗼𝘂𝗴𝗵 𝘁𝗵𝗮𝘁 𝗶𝘁 𝘄𝗮𝘀 𝗮𝗯𝗹𝗲 𝘁𝗼 𝗿𝗲𝘀𝗽𝗼𝗻𝗱 𝗮𝘀 𝘁𝗵𝗲 𝗻𝗮𝘁𝗶𝘃𝗲 𝗯𝗿𝗮𝗶𝗻 𝘄𝗮𝘀 𝗿𝗲𝘀𝗽𝗼𝗻𝗱𝗶𝗻𝗴.” – Madison Wilson In our research highlight with Madison Wilson and Martin Thunemann, readers can learn all about collaborative research done at the University of California San Diego and Boston University to integrate human cortical organoids in the mouse brain. Using a combination of techniques including electrical measurements for fast timescale recordings, and multiphoton imaging for a wide field-of-view visualization, they explored the development, maturation, and integration of the resulting human neuronal networks. Give it a read to hear more about their novel research! #neuroscience #organoids #womeninstem

⚡ 𝗢𝘂𝗿 𝗻𝗲𝘄 𝗢𝗽𝘁𝗼𝗩𝗼𝗹𝘁 𝗺𝗼𝗱𝘂𝗹𝗲 𝗵𝗮𝘀 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗽𝘁𝗶𝗰𝘀 𝘁𝗵𝗮𝘁 𝗲𝗻𝗵𝗮𝗻𝗰𝗲 𝘀𝗽𝗲𝗲𝗱 𝗮𝗻𝗱 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗵𝗶𝗴𝗵-𝘀𝗽𝗲𝗲𝗱 𝘃𝗼𝗹𝘁𝗮𝗴𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴. These multiplication optics re-route the resonant scanning beam for customized aspheric microlens arrays. This results in the scan speed being multiplied up with the microlens array, and the resulting multiplication factor is based on the number of microlenses scanned across. This module is seamlessly integrated with the Ultima 2Pplus multiphoton microscope and lets researchers build upon their existing microscope system as their research develops. Take a look at this unique multiplication architecture for voltage imaging neural research. Diagram courtesy of Sheng Xiao, Mertz Lab, Boston University. #neuroscience #optogenetics #microscopy

🖥️ 𝗪𝗼𝘂𝗹𝗱 𝘆𝗼𝘂𝗿 𝗹𝗮𝗯 𝗯𝗲𝗻𝗲𝗳𝗶𝘁 𝗳𝗿𝗼𝗺 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝗽𝗵𝗼𝘁𝗼𝗺𝗮𝗻𝗶𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗲𝘅𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝘁𝘀? ▶ https://lnkd.in/eUPRbaW5 📔 Our tech note “Automating Photomanipulation on the Acquifer IM” is a great resource for learning how Bruker’s Acquifer Imaging Machine (IM) and photomanipulation module provide researchers with the ability to easily scale up complex photomanipulation experiments. Unique features such as an optomechanical design with moving optics and a stationary sample holder ensure precise photomanipulation. Give this technical note a read to see how these innovative technologies support experiments including photodamaging, uncaging, and optogenetics for advanced studies in cell biology and biomedicine. #data #analysis #microscopy

Our own Kevin Mann is giving a talk titled “Imaging the Dynamics of the Nervous System” for BioPhotonics on Thursday, October 17th at 7:30 am. Kevin’s talk will discuss how multiphoton #microscopy can be used to explore neural circuits and brain function like never before. Tune in to hear about Bruker’s unique offerings, including: • The Ultima 2Pplus multiphoton workstation for in-vivo imaging at single-cell resolution • The NeuraLight 3D Ultra Spatial Light Modulator (SLM) for advanced optogenetics experiments • The NeuraLeap Module for Digital Micromirror Device (DMD) Focusing and rapid imaging across depths • The new OptoVolt module for high-speed voltage imaging at single-neuron resolution Register or log in to watch here: https://lnkd.in/graBCJdC #MicroscopyMonday #neuroscience

🧠 Thank you to everyone who attended Society for Neuroscience 2024 and visited our booth! It was great to connect with so many amazing researchers from the neuroscience community. 📣 We hope you had a great time at our symposium “Multimodal Neuronal-Imaging: From Synapses to Circuits.” We are super grateful for the big turnout and the guest speakers who presented their novel uses of different fluorescent microscopy imaging techniques for neuroscience research. 🔬 Our fluorescent microscopy and spatial biology solutions continue to support the evolving field of neuroscience. Stay connected with Bruker to hear about the latest news on our products, new publications, and other events we’ll be at. ✈️ Safe travels and see you next year! #SfN24 #neuroscience #brain Society for Neuroscience

We are super excited about this addition and the impact it will have alongside our fluorescent microscopy portfolio. These innovative technologies will enable a range of advanced research in #neuroscience, #genomics, and more! #SpatialBiology #Bruker #Innovation

⚡ 𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝘁𝗵𝗲 𝗢𝗽𝘁𝗼𝗩𝗼𝗹𝘁 𝗠𝗼𝗱𝘂𝗹𝗲 𝗳𝗼𝗿 𝗵𝗶𝗴𝗵-𝘀𝗽𝗲𝗲𝗱 𝘃𝗼𝗹𝘁𝗮𝗴𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝘁 𝘀𝗶𝗻𝗴𝗹𝗲-𝗻𝗲𝘂𝗿𝗼𝗻 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 The OptoVoltTM Module for Ultima 2Pplus multiphoton microscopes enables voltage imaging neural research with significant improvement over standard imaging techniques by capturing electrical dynamics at up to 1000 frames per second. With the emergence of fluorescent voltage indicators, researchers are excited to measure neural activity with higher temporal resolution than traditional fluorescent calcium indicators have allowed. 𝗢𝗽𝘁𝗼𝗩𝗼𝗹𝘁 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗳𝗲𝗮𝘁𝘂𝗿𝗲𝘀: - Multiplication and large detection optics - Custom FPGA-based digitizers - Seamless integration with Ultima 2Pplus and NeuraLight 3D Ultra Spatial Light Modulator 𝗢𝗽𝘁𝗼𝗩𝗼𝗹𝘁 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝗲𝗺𝗲𝗿𝗴𝗶𝗻𝗴 𝗮𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀, 𝗶𝗻𝗰𝗹𝘂𝗱𝗶𝗻𝗴: - All-optical functional mapping with a combination of 3D optogenetics and voltage imaging - Measurement of sub-threshold cellular membrane potentials - Calcium, vascular, and neurotransmitter imaging This innovative technology is being featured at Society for Neuroscience 2024 in Bruker’s booth #424. Come see it for yourself and discuss with experts how OptoVolt can enhance your voltage imaging research! Read the full press release here: https://lnkd.in/dv9u8mV5 Visit our webpage for more details: https://lnkd.in/d3m_GvZv #neuroscience #microscopy #MicroscopyMonday #optogenetics