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This is Your Brain on Magic Mushrooms! 🍄🧠 A new #Nature study led by Josh Siegel shows that high doses of psilocybin cause widespread changes in brain function, desynchronizing brain activity and altering our sense of self, time, and space. This desynchronization may drive brain plasticity triggered by psych€-delics. 🍄 Researchers tracked healthy adults before, during, and weeks after a psilocybin dose. They found profound desynchronization across the cerebral cortex and subcortex, especially in the default mode network (DMN), crucial for our sense of self. 🧠 Psilocybin’s disruptive effects decreased when participants focused on simple tasks, suggesting a basis for grounding during psychedelic therapy. 🍄 The study also showed a lasting decrease in connectivity between the anterior hippocampus and DMN circuits, controlling self-oriented thinking and memory. This shift might change how someone perceives their place and story in the world, potentially explaining psilocybin’s antidepressant effects. This study is likely the most advanced and extensive study on the brain effects of psych€-delics ever conducted, involving roughly 18 magnetic imaging visits per participant. Psychedelic science is moving fast, very curious for what will come next. https://lnkd.in/dgX-VhJB #mentalhealth #psychiatry #neuroscience #pharmacology