Forge Biologics

Celebrating National Manufacturing Day at Forge!   Today, we observe the vital role of advanced biomanufacturers in shaping the future of healthcare. Our work at Forge and the work of our partners, helps deliver life-changing gene therapies, offering hope to patients and their families around the world. We are proud to be part of this community of innovators.   A special thank you to our incredible manufacturing teams who, every day, ensure that the therapies they work on are safe, effective, and accessible to those who need them most. Your dedication and hard work do not go unnoticed and we’re grateful for everything you do!   Hear from two of our amazing manufacturing team members, James Hicks, GMP Support Technician II, and Madeline Wiles, SME Fill Finish, as they share what working in GMP at Forge means to them in the video below.   #NationalManufacturingDay #ForgeWithUs

In celebration of our FUEL™ platform launch, we asked our Forgers: ‘What fuels you?’ From our shared mission and team camaraderie to a strong cup of coffee, discover what gives them the extra boost to power through their day!

We are excited to announce FUEL™, our AAV manufacturing platform that combines our groundbreaking technologies, proven manufacturing processes, and strategic optimization packages to provide developers with a more efficient solution for gene therapy production. Key technical advancements of FUEL™ include our new pEMBR 2.0™ Ad helper plasmid – one of the smallest Ad helpers commercially available – and new modified rep/cap plasmids designed for increased safety and higher AAV yields. With these innovations, the FUEL™ platform can achieve a 2-6x increase in productivity compared to industry standard. Read the full press release here ➡️ https://bit.ly/4eKcF3Z

Wrapping up an exciting week at BPI in Boston! Team members Aghiad Alkhiamy, Jeff Habel, Ph.D., and Don Belcher, Ph.D., were in attendance for BioProcess International last week where they presented posters covering the technical advancements coming out of our process development and plasmid manufacturing teams. In case you missed us at BPI, our team will be at the Alliance for Regenerative Medicine's Meeting on the Mesa next week! Connect with our AAV experts there: https://bit.ly/3ZGJjiF

🧬 3 Tiers for AAV Potency Assay Development Success 🧬 A flexible approach to quantitative potency assay development is essential at every stage. In our latest Endpoints News article, discover how Forge’s stage-agnostic, tiered approach helps meet this critical need. Rachael Hardison, Ph.D., shares how Forge has enhanced transduction efficiency through dose-response experiments and innovative transduction enhancers. The article also includes a step-by-step framework for seamless tech transfer of potency assays from developers to their CDMO partners. Contributing authors: Samantha Powers, PhD, Scientist II, Analytical Development Julia Z., Associate Scientist II, Analytical Development Read more here: https://hubs.li/Q02RxX3M0

We’ve been asked, why Columbus? Our CFO, Christina Perry, highlights why Forge is proud to call Columbus home and details how this region gives us a competitive edge with: • A rich legacy of cell and gene therapy innovation • A pipeline of top-tier talent from local universities and programs like CSCC’s Biotech Bootcamp • Lower build and utility costs compared to the coasts • Strong industry partnerships driving innovation and growth • And more! Check out the full article here ➡️ https://hubs.li/Q02Rph6K0

September marks Leukodystrophy Awareness Month. Throughout the month, we've been shining a light on individuals and families affected by Krabbe disease, a rare leukodystrophy. Today, we’re spotlighting a leukodystrophy pioneer at Forge, Our Chief Medical Officer, Maria L Escolar, MD, MS Learn more about how our purpose-driven core value guides Dr. Escolar, her love of dancing, and how the development of FBX-101 for patients with Krabbe disease is her proudest achievement. Get the full scoop on Dr. Escolar and all of our other Genes of Interest profiles here ➡️ https://hubs.li/Q02RfksK0

Phoenix-bound for Meeting on the Mesa! Our incoming President & CEO, John Maslowski, will take the stage at the Alliance for Regenerative Medicine's annual event. Catch his presentation on October 8 at 3:15 pm MST in FLW Ballroom F. Other ways to connect with our team October 7-9: 🗓 October 7-9: Schedule a private meeting with Forge 🍽 October 8, 7 pm: Attend our Fueling Innovation reception Let’s connect! Learn more and join us here ➡️ https://hubs.li/Q02R4xpl0

Big thanks to the PDA - Parenteral Drug Association (PDA) Midwest for hosting their 2024 Ohio event at the Hearth! It was a privilege to have our Vice President of Quality Management, Meghan Leonard share insights on Forge’s demonstrated commitment to quality, alongside other expert speakers. Attendees delved into key topics, including Contamination Control Strategies for ATMP manufacturing. We were grateful to host such an impactful event!

Hiring spotlight: GMP Manufacturing Lead – Upstream! We are looking for an experienced GMP manufacturing lead to help manage our upstream GMP team. Ready to drive excellence in gene therapy manufacturing? Here's what you'll be doing 👇 • Oversee a talented group of technicians • Drive upstream processes to support groundbreaking gene therapy advancements • Ensure strict adherence to GMP and regulatory requirements throughout the manufacturing process • And more! Forge is powered by a diverse, driven, and passionate team, working together to transform how medicines are made for patients with genetic diseases. Apply now and help us shape the future of gene therapy Learn more here ➡️ https://hubs.li/Q02QM-BS0