CDMOs Need to Convince Customers of New Technology Benefits Innovative technologies that have the potential to save manufacturers time and money are likely to be an easy sell, says Sarah Alter, PhD, OrganaBio's senior director of scientific affairs, citing artificial intelligence-based modeling as an example.
Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News (GEN) is the flagship publication of Mary Ann Liebert, Inc. Celebrating its 40th anniversary in 2021, GEN was the first publication in this field and remains the key driver in the explosion of the industry, paving the way for the development of new tools and technologies, investment growth, and career opportunities. Through its cornerstone Magazine, dynamic Website, high-frequency eNewsletters, and innovative suite of multimedia, GEN is the 360-degree resource that researchers and executives depend on for information that is pivotal for their success. GEN’s breadth of editorial coverage is unrivaled, providing exclusive reporting, insight, and analysis across the life sciences – from its five foundational pillars of Drug Discovery, Bioprocessing, OMICS, Translational Medicine, and Gene Editing to a new, expanded focus on the emerging areas of Cancer Research, Infectious Diseases, and Artificial Intelligence. Within these areas, GEN delivers exclusive, high-quality reporting on the latest industry news; insider information on cutting-edge tools and technologies; industry-standard protocols, tutorials, and technical articles; first-looks at emerging industry collaborations and investments; reports from key scientific and industry meetings; and A-Lists, our monthly insight and analysis into the top companies, products, and movers & shakers impacting the industry today.
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External link for Genetic Engineering & Biotechnology News
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Updates
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Embracing “Worst-Case Studies” for Upstream Development Showing the power of modeling in gathering valuable information could encourage more people to use these tools for their own work. Wilhad H. Reuter, lead engineer for upstream process development at Mural Oncology spoke with GEN about his team's Design of Experiment (DoE) approach that allowed them to narrow down the factors that affect product quality.
Embracing “Worst-Case Studies” for Upstream Development
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Enhanced Bioproduction through Multicopy Integration Researchers at the French Institute of Petroleum (IFP Energies nouvelles) have developed a way to further enhance the production of a fungus known to secrete proteins at a high level.
Enhanced Bioproduction through Multicopy Integration
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Vertical Plant-Based Protein Expression: Lower Cost, Reduced Footprint Alternative Molecular farming may offer advantages over traditional systems due to new technologies that scale production with a reduced footprint. GEN speaks with Don Stewart, CEO of PlantForm Corporation.
Vertical Plant-Based Protein Expression: Lower Cost, Reduced Footprint Alternative
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Optimizing Microcarriers Even after more than 50 years of using microcarriers in culturing and bioprocessing, though, Majid Ebrahimi Warkiani, PhD, a professor in the school of biomedical engineering at the University of Technology Sydney in Australia, and his colleagues recently noted that “innovation in this sector has been limited, leading to challenges in industrial scaling.”
Optimizing Microcarriers
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Tackling AI Bottlenecks in Bioprocessing Despite AI's potential in bioprocessing, it will take time before bioprocessors can really get the most out of AI-based tools. GEN spoke with four experts Richard D. Braatz, PhD, from Massachusetts Institute of Technology (MIT), Wei Xie, PhD, from Northeastern University, Anurag S. Rathore, PhD, from Indian Institute of Technology, Delhi, and Barkha Singhal, PhD, from Gautam Buddha University.
Tackling AI Bottlenecks in Bioprocessing
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With $5.3M in Funding, clock.bio Makes Progress on Longevity Research Using Stem Cells Read more: https://hubs.li/Q02T4d5-0 The newly-minted company set out to decode the self-rejuvenation mechanism used by human iPSCs to overcome the hallmarks of aging and to understand which genes regulate this process. Their goal is to ultimately to find drugs that target these genes with an eye toward potentially stopping and reversing associated diseases and disorders.
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Hubble Therapeutics Taps Andelyn to Manufacture Clinical Grade AAV for Eye Disorder Gene Therapy HUB-101 has received Rare Pediatric Disease Designation and Orphan Disease Designation from the FDA for this program. Andelyn will optimize and scale up the HUB-101 process, generate GMP-grade plasmids, and produce GMP vectors that include normal copies of the KCNJ13 gene.
Hubble Therapeutics Taps Andelyn to Manufacture Clinical Grade AAV for Eye Disorder Gene Therapy
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Viruses Lured to Their Doom by Cytoplasmic Condensates A new study by researchers at the VIB-UGent Center for Medical Biotechnology and collaborators demonstrates how a protein linked to the human immune system lures and traps HIV-1 and herpes simplex virus-1. The findings revealed the protein MX2 lures and traps these viruses by assembling structures in the cell.
Viruses Lured to Their Doom by Cytoplasmic Condensates
genengnews.com
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Nobel Laureate David Baker (University of Washington and Howard Hughes Medical Institute (HHMI)) headlines GEN's inaugural AI in Drug Discovery Summit on October 30th! This free virtual event, sponsored by Microsoft and Revvity Signals will feature an outstanding group of thought-leaders, researchers and AI entrepreneurs across industry and academia, to showcase the latest advances, challenges and concerns regarding the deployment of AI in biotech, with particular emphasis on disrupting the drug discovery process. To register for free, visit: https://hubs.li/Q02T8cBR0