Lafayette Instrument Company

Clocking Gains: How Time of Day Impacts Muscle Contractility after Satellite Cell Loss! Using Aurora Scientific’s #300E Dual-Mode Muscle Lever, Ryan Kahn et al. investigated the relationship between #circadian rhythms and #muscle function, particularly focusing on the role of satellite cells, which are essential for muscle repair and regeneration. Check it out here! https://lnkd.in/gb4meWMK More about the 300E! https://lnkd.in/gvadJwcQ

📢 𝗡𝗲𝘄 𝗧𝗼𝘂𝗰𝗵𝘀𝗰𝗿𝗲𝗲𝗻 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗔𝗹𝗲𝗿𝘁!🧠🚬 A recent study published in the 𝗝𝗼𝘂𝗿𝗻𝗮𝗹 𝗼𝗳 𝗡𝗲𝘂𝗿𝗼𝗰𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 titled "𝗦𝗲𝘅-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗼𝗳 𝗻𝗶𝗰𝗼𝘁𝗶𝗻𝗲 𝘁𝗼 𝗺𝗼𝗱𝘂𝗹𝗮𝘁𝗲 𝗱𝗶𝘀𝗰𝗿𝗶𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝘃𝗲 𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗶𝗻 𝗺𝗶𝗰𝗲," sheds light on how nicotine affects learning and cognitive flexibility differently in male and female mice. 🔍 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: - The research indicates that while nicotine is often associated with improved attention and learning, these effects vary significantly between the sexes. - Researchers utilized 𝘁𝗼𝘂𝗰𝗵𝘀𝗰𝗿𝗲𝗲𝗻-𝗯𝗮𝘀𝗲𝗱 𝘁𝗮𝘀𝗸𝘀 to assess two types of cognitive processes: 𝘃𝗶𝘀𝘂𝗮𝗹 𝗱𝗶𝘀𝗰𝗿𝗶𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 and 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝘃𝗲 𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆.  - In the 𝘃𝗶𝘀𝘂𝗮𝗹 𝗱𝗶𝘀𝗰𝗿𝗶𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝘁𝗮𝘀𝗸, mice learned to distinguish between two visual cues to receive a reward. Nicotine was found to enhance performance in males, but the effects were less pronounced in females.  - For 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝘃𝗲 𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆, mice were required to adapt when task rules were changed. The study showed that nicotine helped males adjust more quickly, while its impact on females was more complex, suggesting potential sex-specific neural mechanisms. - The use of touchscreen tasks provided a 𝗽𝗿𝗲𝗰𝗶𝘀𝗲 𝗮𝗻𝗱 𝗿𝗲𝗹𝗶𝗮𝗯𝗹𝗲 𝗺𝗲𝗮𝘀𝘂𝗿𝗲 𝗼𝗳 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗮𝗱𝗮𝗽𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆, offering deeper insights into how nicotine may influence behaviour. 💡 𝗪𝗵𝘆 𝗜𝘁 𝗠𝗮𝘁𝘁𝗲𝗿𝘀: Understanding the sex-dependent effects of nicotine on the brain could lead to 𝗺𝗼𝗿𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 for managing nicotine addiction, mental health, and cognitive impairments. This research underscores the importance of considering sex differences in preclinical studies, paving the way for more tailored and equitable health solutions. For those interested in diving deeper into the study, read the full paper https://lnkd.in/eqzPmmrT. 🧬📊 MouseTRAP #animalbehavior #neuroscience #cognition

It was great to have Cassandra Deichsel visit our office!

New publication alert! CUTE Devices: Where High-Fidelity Meets High-Fun in Haptic Tech! Sanchez-Tamayo et al. recently published "Cutaneous Electrohydraulic (CUTE) Wearable Devices for Pleasant Broad-Bandwidth Haptic Cues." With Aurora Scientific’s Dual-mode muscle lever (310C-LR), researchers confirmed the device can deliver realistic and highly immersive tactile experiences, paving the way for next-generation haptic feedback technologies. Check it out! https://lnkd.in/deG3AhFj

Testing #contractility and force production of pathological #cardiac tissue has been a reliable and well-known measure of the development of cardiomyopathies. This measurement technique has also been used to test therapies which aim to treat cardiomyopathies. However, understanding how #ATPconsumption of pathological tissues changes when therapeutics are present is also valuable. Utilizing the measurement of NADH conversion to NAD+ via our 804A system will give researchers an indication of overall ATP consumption! https://lnkd.in/gc9FfvkQ

Nam et al., is making strides in the #VML community, developing a promising candidate for clinical applications in soft tissue repair. Researchers have developed a hydrogel-based adhesive that offers strong-tissue adhesion, rapid self-healing, and injectability. Using in-vivo and in-vitro studies this material proved to be biocompatible with minimal immune response and #muscleregeneration promotion in animal models. #3in1 #1300A Check it out here! https://lnkd.in/gYP9KSrs

Mark your calendars for our upcoming virtual demo with Aurora Scientific, where Chris Rand, MSc will provide an overview of the typical applications, capabilities and general use of the 220A Olfactometer and 200C miniPID in the field of olfaction. Secure your spot: https://bit.ly/3NciKdz *This demo is exclusively available to those who attend the live event.*

Collateral sprouting: nerves going out on a limb to heal the skin's sensations! Check out the recent publication "Skin reinnervation by collateral sprouting following spared nerve injury in mice" by Jeon et al. (https://lnkd.in/gGvww5hG). The team investigates the process of skin reinnervation through collateral sprouting after nerve damage and utilized the #AuroraScientific 300E-I Dual-Mode Indenter. #neuroscience About the 300E-I Dual-Mode Indenter https://lnkd.in/gFChFZYR

Brian and Jackson are attending APTA PPS in National Harbor. If you are in there, be sure to stop by and check out our new DualGrip Dynamometer and a selection of Kinvent products!

Hello from our #SfN24 crew. It's the last day, let's make it a good one!