RedShiftBio

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Poster Refresh! Check out this collaboration done with ichorbio; Structure, Stability, Similarity, and Stress Characterization of Trastuzumab and Two Biosimilar Drugs Using Microfluidic Modulation Spectroscopy (MMS) MMS is a robust and automated tool that can be used to quickly and easily analyze protein structure and determine change qualitatively, using the delta plots, or quantitatively using the percent similarity, HOS percentages, or the weighted spectral difference, simplifying the decision-making process when analyzing samples for comparability. 

It's that time again! Where we gladly present a new app note of course! Titled: Structural Characterization of Antibody Drug Conjugates as Formulated and Under Multiple Conjugation Paradigms. Full article can be downloaded here: https://lnkd.in/eKsa5K6i

We have several seats available for our Protein and RNA Structural Analysis Symposium on Thursday, September 19th held in person at the MassBio facility in Cambridge MA.   Hear from guest speakers of Pfizer, Genentech, US Pharmacopeia, and The City University of New York among others on how they break through the challenges of analyzing structure and characterizing their biomolecules. Engage with our panel discussion and partake in Q&As throughout the day's sessions.   Register here and we look forward to seeing you! https://lnkd.in/eCVf2wqV

What is just as informative as attending a conference? Checking out our new app note of course 😃 Thermal stress is the most common stress condition utilized for gauging protein stability. However, techniques to measure the effects of thermal stress such as UV melts, circular dichroism (CD), and differential scanning calorimetry (DSC) typically only provide an overall melt temperature, Tm, and thermodynamic parameters, with very low granularity on structural changes associated with the melt. Microfluidic Modulation Spectroscopy (MMS) is an automated mid-IR technique capable of measuring protein secondary structure at very high resolution across a broad range of concentrations and buffer conditions. MMS can be used to measure and monitor the structural changes that are occurring, leading to protein unfolding, and then thermally induced aggregation. In this study, we started by measuring thermal unfolding for lysozyme across a range of pH values and found the Tm to be pH-dependent. Next, we melted an IgG across a range of concentrations and found the Tm to be modestly concentration-independent. Finally, we used MMS to determine the structural differences of the two Tm values determined for ovalbumin. The document can be downloaded here: https://lnkd.in/et8iG2RP

Are you attending the Higher Order Structure of Protein Therapeutics (HOS) Symposium? David Sloan of RedShiftBio is presenting on 9/11 at 2:25 pm on Analyzing RNA Structure Using Microfluidic Modulation Spectroscopy (MMS) and Measuring Structural Changes in Riboswitches. More information can be found here. Hope to see you there! https://lnkd.in/e7hCyvGm

We are hosting a Symposium at MassBio highlighting the importance of structural characterization of Proteins, RNA, and more on September 19th. There will be a panel discussion with speakers and guests from Pfizer, USP, Genentech, J&J, CUNY along with a Q&A session. Come join us to network and participate in this exciting event! Register: https://lnkd.in/eCVf2wqV

We are excited to host a cutting-edge symposium focusing on protein and RNA structure utilizing our Microfluidic Modulation Spectroscopy (MMS) technology. We have organized a fabulous line-up of scientists to present their research on how they are utilizing MMS to solve their scientific challenges. We will hear from Pfizer, Genentech, US Pharmacopeia, The City University of New York, and RedShiftBio. Alongside these insightful presentations we will also have ample time for Q&A as well as a panel discussion focused on the importance of structural characterization of biomolecules for therapeutic development, control reagent characterization, and deeper mechanistic studies. We are looking forward to an inspiring day of research, networking, and scientific discourse. This event will be held at MassBio in Cambridge MA. Please follow this link to sign up: https://lnkd.in/eCVf2wqV

We are delighted to have Yuxiang (Henry) Zhao of Bristol Myers Squibb give the following presentation at #CHIBioprocessingSummit tomorrow at 2:30 pm. HaLCon Protein Analyzer: A Study on At-Line Titer Analysis in Biopharmaceutical Applications With the increasing demand for intensified processes in biopharmaceutical manufacturing, there is a growing requirement for a rapid and precise analytical method to measure product yield. This talk presents a case study on the HaLCon protein analyzer, a compact Liquid Chromatography (LC) system equipped with a Protein A affinity column. The study investigates the capabilities, performance, and potential applications of HaLCon in GMP facilities. We will be at booth 615 to answer any questions after the seminar. Cambridge Healthtech Institute

Attendees of #CHIBioprocessingSummit! Interested in a rapid method to measure titer right from your bioreactors? Check out the poster presentation by Nida Sayed Zubairy of Boston Institute of Biotechnology tonight and tomorrow. A13: A Comparative Study to Evaluate Different Analytical Methods Used to Quantify a Fusion Protein and Two Types of IgG Molecules Produced in CHO Cell Line, Presented by Nida Z., Boston Institute of Biotechnology And be sure to stop by RedShiftBio's booth 615 to learn more about Halcon and Aurora TX instruments! www.redshiftbio.com