Congratulations to our amazing Institute Scholar Hawa Racine Thiam for being named a 2024 Packard Fellow! https://bit.ly/3UcAE3P
Sarafan ChEM-H | Stanford University
Research
Stanford, California 1,590 followers
Sarafan ChEM-H at Stanford University is a hub of innovation that brings the power of diversity to improve human health.
About us
Sarafan ChEM-H at Stanford University is a hub of innovation that harnesses the power of diversity – of disciplines and people – to advance human health and transform research, as well as recruit and train the next generation of scientific leaders. Its two major research initiatives, the Stanford Innovative Medicines Accelerator (IMA) and the Stanford Microbiome Therapies Initiative (MITI), aim to translate promising Stanford discoveries into new kinds of therapeutics for patients.
- Website
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http://chemh.stanford.edu
External link for Sarafan ChEM-H | Stanford University
- Industry
- Research
- Company size
- 51-200 employees
- Headquarters
- Stanford, California
- Type
- Educational
- Founded
- 2014
- Specialties
- Chemistry, Biology, Medicine, Human Health, Higher Education, Science, Microbiomes, Medicinal Chemistry, High-throughput Screening, Experimental Human Biology, and Drug Discovery and Prototyping
Locations
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Primary
290 Jane Stanford Way
Stanford, California 94305, US
Employees at Sarafan ChEM-H | Stanford University
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Vi Dang
Administrative Associate 4 at Stanford University
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Elizabeth Ponder
Executive Director / Non-profit & higher education leader / Drug discovery & innovation / Global Health / Diversity in STEM
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Maria Fraboni
Financial Analyst - Sarafan ChEM-H at Stanford University
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Karin Stein
Medicinal Chemist
Updates
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Sarafan ChEM-H | Stanford University reposted this
🚨 New Publication Alert 🚨 We are thrilled to announce the release of our Lysosomal Brain Atlas, now available on bioRxiv! This comprehensive resource provides deep insights into the lysosome's role across distinct brain cell types—neurons, astrocytes, microglia, and oligodendrocytes. In this study co-led with Ali Ghoochani, we used cell-type-resolved organelle purification (LysoIP) and high-resolution mass spectrometry to map the lysosomal protein compositions at unprecedented resolution, unveiling novel cell-type-specific functions. A highlight of our work is the identification of SLC45A1 as neuron-specific lysosomal protein and novel regulator of both lysosomal acidity and sugar export. This finding redefines SLC45A1-associated neurological diseases as a new lysosomal storage disorder, opening fresh research avenues into how lysosomal dysfunction contributes to neurological diseases. This atlas is a crucial resource for understanding lysosomal biology and its role in brain diseases, with implications spanning cell biology, neurobiology, genetics, and biochemistry. This work was a collaboration between the Ori Lab at Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) and the Abu-Remaileh Lab at Sarafan ChEM-H | Stanford University. Huge thanks to Alessandro Ori, Monther Abu-Remaileh, Eshaan Rawat, Uche Medoh, PhD, Domenico Di Fraia, Wentao Dong, Marc Gastou, PhD, Kwamina Nyame, Nouf Laqtom and Natalia Gomez-Ospina MD, PhD! We would also like to thank our funding agencies: the NCL-Stiftung, Fritz-Thyssen Foundation, Beatbatten, the NIH Director’s New Innovator Award Program, the Knight Initiative for Brain Resilience at Stanford University, the Chan Zuckerberg Initiative Neurodegeneration Challenge Network, and Aligning Science Across Parkinson’s through the Michael J. Fox Foundation for Parkinson’s Research (MJFF), as well as the German Research Council (DFG) via the Research Training Group ProMoAge. Read the full paper: https://lnkd.in/ehRdHX_c #Lysosomes #CellBiology #SLC45A1 #OrganelleBiology #Neurobiology #Neuroscience #BioRxiv #LysosomalBrainAtlas
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Sarafan ChEM-H | Stanford University reposted this
Chat with a Nobel Prize! Join us for an open discussion with Carolyn Bertozzi The Nobel Prize winner in Chemistry 2022. Save the date: Wednesday, October 23 at Noon. Register here: https://lnkd.in/giqCzhvF Stanford CVI Mavens Stanford University School of Medicine Stanford University Sarafan ChEM-H | Stanford University Stanford University Postdoctoral Association (SURPAS)
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“This is an embarrassingly simple solution to an old problem” New research from our director of medicinal chemistry Mark Smith and team reports a new prodrug strategy to increase the bioavailability of oral drugs, potentially turning IV-administered medicines for #cancer patients into non-toxic pills that are effective at lower doses and more accessible: https://lnkd.in/ehm8HmvP
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Congratulations to our Institute Scholar Christopher Barnes for winning the 2025 Biophysical Society Early Independent Career Award! https://lnkd.in/gxJYHF_m
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Sarafan ChEM-H | Stanford University reposted this
Bioengineering PhD Student @Stanford University || SGF Research Fellow || Sarafan ChEM-H CBI Training Program
Excited to share that I’ve just started my PhD in Bioengineering at Stanford University. I’m also honored to be a recipient of the Stanford Graduate Fellowship in Science and Engineering and to join the Sarafan ChEM-H | Stanford University Chemistry-Biology Interface Training Program. Huge thanks to everyone who’s supported me along the way—I’m looking forward to what’s next!
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Congratulations to our Institute Scholar Hawa Racine Thiam for being featured in this year's SN 10: Scientists to Watch list! She is being recognized for her work in demystifying cell movement mechanics, and its implications for human health: https://bit.ly/3XXHqMb
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Institute Scholar Steven Banik, Christine Ng, and team devised a new class of bifunctional molecules called “targeted relocalization activating molecules” or TRAMs to convince natural cellular shuttles to bring misplaced, disease-related proteins back to their homes within cells. This could lead to new treatments for cancers and neurodegeneration as well as potentially create new functions in cells: https://lnkd.in/e898qF-Z
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Sarafan ChEM-H | Stanford University reposted this
Drug Hunter. Senior Advisor (Molecule Discovery). Former HHMI Gilliam Fellow & Peace Corps Volunteer.
Neat paper from the Banik lab on proximity-based targeted protein relocalization where they were able to show that target proteins can be relocalized by shuttle proteins. Super cool! #TPD #proteins #proximity #relocalization Sarafan ChEM-H | Stanford University https://lnkd.in/ghNUDaFG
Targeted protein relocalization via protein transport coupling - Nature
nature.com