Targeting Extracellular Vesicles

New Strategies for the Targeting of Central Regulation of Obesity with a Nanotechnology Approach using Engineered Extracellular Vesicles by ramaroson andriantsitohaina won the best scientific contribution #award. Hi talk covered how small extracellular vesicles (sEVs) can target SF1 neurons in the ventromedial hypothalamus (VMH) to reduce body weight without changing food intake. This innovative approach offers promising insights into treating obesity and its comorbidities, potentially revolutionizing therapeutic strategies for neurological diseases. The International Society of Microbiota and the World Mitochondria Society thank Ramaroson for his outstanding contribution! #ExtracellularVesicles #ObesityResearch #Nanotechnology #InnovativeTherapies #WMS #ISM #ScientificContribution

The role of extracellular vesicles (EVs) in mitochondrial quality control for skin aging and disease, #BestShortOralPresentation Award! Congrats to Maria Cavinato from the Universität Innsbruck for winning the Best Short Oral Presentation Award at the First Conference on Targeting Extracellular Vesicles in Malta! Her presentation, "Extracellular Vesicles as Alternative Modulators of Mitochondria Quality Control in Skin Aging and Disease," reveals how NIX-dependent mitophagy impacts skin homeostasis and highlights the role of EVs containing mitochondria as potential compensatory mechanisms for maintaining skin health. The International Society of Microbiota and the World Mitochondria Society thank Maria Cavinato for her valuable contribution. #ExtracellularVesicles #SkinAging #Mitochondria #ScientificBreakthrough #EVTaskForce #SkinHealth #MitochondriaQualityControl

Can EVs be the hidden link between cancer and cardiovascular anomalies? #BestPoster Award! Congrats to Deimantė Kulakauskienė from the Lithuanian University of Health Sciences for winning the Best Poster Presentation Award at the First Conference on Targeting Extracellular Vesicles in Malta! Her research, "The Investigation of Glioblastoma-Derived EVs Effect on Cells in the Cardiovascular System," shows that small EVs boost mitochondrial activity in cardiomyocytes, while both small and large EVs inhibit endothelial cells—potentially transforming our understanding of cancer’s impact on cardiovascular health! The International Society of Microbiota and the World Mitochondria Society thank Deimantė Kulakauskienė for her contribution. #ExtarcellularVesicles #CancerResearch #CardiovascularHealth #ScientificBreakthrough #EVTaskForce #Mitochondria

Testing the potency of extracellular vesicles derived from differentiating mesenchymal stem cells reveals promising applications in wound healing. Edda Tobiasch from Bonn-Rhein-Sieg University of Applied Sciences, Germany, presented her innovative research at #TargetingEVs2024, utilizing an adapted wound assay to evaluate the effectiveness of these extracellular vesicles. Her findings highlight the potential of mesenchymal stem cell-derived extracellular vesicles in promoting wound healing, paving the way for new therapeutic strategies in regenerative medicine. #TargetingEVs #extracellularvesicles #exosomes #stemcells #woundhealing #regenerativemedicine #therapy

CD34+ microparticles influence the apoptotic mechanisms of mononuclear cells derived from umbilical cord blood and HL60 cells. ANGELIKI XAGORARI from G. Papanikolaou Hospital, Greece, presented her intriguing research at #TargetingEVs2024, exploring the impact of these microparticles on cell apoptosis. Her findings shed light on the potential therapeutic implications of CD34+ microparticles in modulating cell survival and death, contributing to advances in regenerative medicine. #TargetingEVs #extracellularvesicles #exosomes #microparticles #apoptosis #cellbiology

The differential transcriptomic profile in platelet-derived extracellular vesicles offers new insights into metabolic dysfunction-associated steatotic liver disease (MASLD). Vanessa García Fernández, Universidad de Sevilla, Spain, shared her compelling research at #TargetingEVs2024, examining how these extracellular vesicles may reflect the underlying mechanisms of MASLD. Her work highlights the potential of platelet-derived extracellular vesicles as biomarkers for early diagnosis and therapeutic targets in managing liver diseases. #TargetingEVs #extracellularvesicles #exosomes #liverdisease #transcriptomics

How can fully synthetic extracellular vesicles (EVs) transform therapeutic applications in biomedicine? Joachim P. Spatz, Max Planck Institute for Medical Research, presented innovative findings on synthetic EVs during #TargetingEVs2024. Main points covered: 🔹 Fully synthetic EVs can be engineered with controlled lipid, protein, and RNA compositions. 🔹 Their functionalities mirror those of natural EVs, enabling targeted therapeutic applications. 🔹 Transcriptome profiling reveals synergistic effects among individual EV components, enhancing our understanding of EV signaling. Dr. Spatz's research highlights the potential of synthetic EVs in advancing treatments for conditions like wound healing and atopic dermatitis. #TargetingEVs #extracellularvesicles #syntheticbiology #biomedicine #therapeutics

How can stem cell-derived extracellular vesicles (EVs) enhance successful aging and combat frailty? At #TargetingEVs2024, Consuelo Borrás Blasco from the University of Valencia shared her research on this crucial topic. Key Highlights: 🔹 EVs are key modulators in cellular responses, influencing aging and oxidative stress. 🔹 They can restore communication disrupted by aging, enhancing the health of recipient cells. 🔹 Young stem cell-derived EVs show promise in reversing age-related declines and improving motor functions. #TargetingEVs #extracellularvesicles #stemcells #aging #frailty #healthyaging

The Gut Microbe-Derived Extracellular Vesicles-Mitochondria Axis in Mental Disorders Seyed Davar Siadat, Pasteur Institute of Iran, presented online data on the interplay between gut microbiota-derived extracellular vesicles (EVs) and mitochondrial function in relation to mental health disorders. Key Insights: 🔹 The gut microbiota forms intricate connections with various body systems, including the gut-brain axis, impacting psychiatric and neurological health through multiple pathways. 🔹 Bacterial EVs are capable of crossing the intestinal barrier, influencing brain function, and potentially contributing to neurodegenerative conditions like Alzheimer's disease. 🔹 Dysbiosis can increase harmful EVs and pathogenic bacteria, compromising gut integrity and leading to neurological disorders, underscoring the significance of the microbiota-mitochondria axis. #TargetingEVs #microvesicles #extracellularvesicles #microbiota #mitochondria #mentalhealth #neurodegeneration

Deimantė Narauskaitė, Lithuanian University of Health Sciences, Lithuania, presented a poster during #TargetingEVs2024: "Impact of Virus Mimetic Poly(I:C)-Primed Airway Extracellular Vesicles on Microglial Mitochondrial Structure and Function" #TargetingEVs #microvesicles #mitovesicles #extracellularvesicles #exosomes #microbiota #mitochondria