TechnoPharmaSphere

𝙒𝙝𝙖𝙩 𝙞𝙛 𝙬𝙚 𝙘𝙤𝙪𝙡𝙙 𝙙𝙚𝙡𝙞𝙫𝙚𝙧 𝙙𝙧𝙪𝙜𝙨 𝙬𝙞𝙩𝙝 𝙩𝙝𝙚 𝙥𝙧𝙚𝙘𝙞𝙨𝙞𝙤𝙣 𝙤𝙛 𝙖 𝙡𝙖𝙨𝙚𝙧?🤔 This is the exciting potential of microfluidics in nano-drug delivery systems! 🧬 Microfluidics is redefining drug delivery, offering precise control over nanoparticle properties and significant advantages over traditional methods. A recent study by Zhang Huan and colleagues highlights how microfluidics can enhance nano-drug delivery systems (#NDDS) by producing uniform particles with controlled size and shape, crucial for effective treatment outcomes. ------------------------------------------ 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: 🔵 𝙀𝙣𝙝𝙖𝙣𝙘𝙚𝙙 𝘾𝙤𝙣𝙩𝙧𝙤𝙡: Microfluidics significantly improves the controllability and uniformity of NDDSs, allowing for precise tuning of physicochemical properties such as particle size, distribution, and morphology🔧 🔵 𝙉𝙖𝙧𝙧𝙤𝙬 𝙋𝙖𝙧𝙩𝙞𝙘𝙡𝙚 𝙎𝙞𝙯𝙚 𝘿𝙞𝙨𝙩𝙧𝙞𝙗𝙪𝙩𝙞𝙤𝙣: The technology enables the production of NDDSs with a narrow particle size distribution, which is crucial for consistent drug delivery and efficacy.📏 🔵 𝙃𝙞𝙜𝙝 𝘿𝙧𝙪𝙜-𝙇𝙤𝙖𝙙𝙞𝙣𝙜 𝘾𝙖𝙥𝙖𝙘𝙞𝙩𝙮: Microfluidics facilitates the creation of NDDSs with high drug-loading capacities, enhancing the therapeutic potential of the delivered drugs.💊 🔵 𝙄𝙢𝙥𝙧𝙤𝙫𝙚𝙙 𝙈𝙞𝙭𝙞𝙣𝙜 𝙀𝙛𝙛𝙞𝙘𝙞𝙚𝙣𝙘𝙮: The fast mixing and laminar flow properties in microfluidic systems lead to better mass transfer and reaction conditions, addressing issues of low mixing efficiency found in traditional methods.⚡ 🔵 𝘿𝙞𝙫𝙚𝙧𝙨𝙚 𝙉𝘿𝘿𝙎 𝙏𝙮𝙥𝙚𝙨: The article discusses various NDDSs synthesized using microfluidics, including liposomes, polymer nanoparticles, and inorganic nanoparticles, highlighting their potential in treating diseases like tumors, diabetes, and asthma.🔬 🔵 𝘾𝙝𝙖𝙡𝙡𝙚𝙣𝙜𝙚𝙨 𝙄𝙙𝙚𝙣𝙩𝙞𝙛𝙞𝙚𝙙: The review points out challenges in the current status of microfluidics-based NDDSs, including scalability, regulatory hurdles, and the need for standardized processes.⚠️ --------------------------------------- How do you see microfluidics influencing the future of drug delivery? #Microfluidics #NanoDrugDelivery #BiopharmaInnovation #FutureOfMedicine #HealthcareRevolution _________________________________________________________________________ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭.   TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m   ⏭ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 lipid nanoparticles 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

𝙒𝙝𝙖𝙩 𝙞𝙨 𝙩𝙝𝙚 𝙎𝙚𝙘𝙧𝙚𝙩 𝙎𝙖𝙪𝙘𝙚 𝙛𝙤𝙧 𝙀𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙢𝙍𝙉𝘼 𝘿𝙚𝙡𝙞𝙫𝙚𝙧𝙮? The secret sauce of lipid nanoparticles (#LNPs) lies in their carefully selected lipid constituents. Understanding these components is crucial for advancing mRNA delivery technologies. But what makes these carriers so effective? A recent study in 𝘼𝘾𝙎 𝙉𝙖𝙣𝙤 uncovers the key lipid constituents that contribute to their success. 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: 𝙄𝙤𝙣𝙞𝙯𝙖𝙗𝙡𝙚 𝘾𝙖𝙩𝙞𝙤𝙣𝙞𝙘 𝙇𝙞𝙥𝙞𝙙𝙨: The authors found these lipids are crucial for mRNA escape from endosomes, becoming positively charged in acidic environments. They explored enzyme-catalyzed synthesis to optimize their performance. 𝙋𝙝𝙤𝙨𝙥𝙝𝙤𝙡𝙞𝙥𝙞𝙙𝙨: Serving as the backbone of LNPs, these lipids ensure stability. The authors used microfluidic mixing to refine their composition. 𝘾𝙝𝙤𝙡𝙚𝙨𝙩𝙚𝙧𝙤𝙡: This component enhances membrane fusion and stability. The study explored various cholesterol structures to improve delivery efficiency. 𝙋𝙀𝙂-𝙇𝙞𝙥𝙞𝙙𝙨: These lipids help LNPs evade the immune system, prolonging circulation time for more effective delivery. 𝙎𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙚-𝘼𝙘𝙩𝙞𝙫𝙞𝙩𝙮 𝙍𝙚𝙡𝙖𝙩𝙞𝙤𝙣𝙨𝙝𝙞𝙥𝙨: Understanding these relationships is vital for designing effective LNPs. Techniques like barcoding were utilized for high-throughput profiling. 𝙁𝙪𝙩𝙪𝙧𝙚 𝙋𝙧𝙤𝙨𝙥𝙚𝙘𝙩𝙨: The authors found potential for LNPs to target tissues beyond the liver, expanding therapeutic possibilities. ----------------------------------------------------- Check out the full article to discover how these insights can enhance your work in biopharma! #Biopharma #Innovation #LipidNanoparticles #LNPs #mRNA #DrugDelivery #GeneTherapy _________________________________________________________________________ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭.   TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m   ⏭ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 lipid nanoparticles 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

𝙒𝙝𝙖𝙩 𝙞𝙨 𝙩𝙝𝙚 𝙎𝙚𝙘𝙧𝙚𝙩 𝙎𝙖𝙪𝙘𝙚 𝙛𝙤𝙧 𝙀𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙢𝙍𝙉𝘼 𝘿𝙚𝙡𝙞𝙫𝙚𝙧𝙮? The secret sauce of lipid nanoparticles (#LNPs) lies in their carefully selected lipid constituents. Understanding these components is crucial for advancing mRNA delivery technologies. But what makes these carriers so effective? A recent study in 𝘼𝘾𝙎 𝙉𝙖𝙣𝙤 uncovers the key lipid constituents that contribute to their success. 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: 𝙄𝙤𝙣𝙞𝙯𝙖𝙗𝙡𝙚 𝘾𝙖𝙩𝙞𝙤𝙣𝙞𝙘 𝙇𝙞𝙥𝙞𝙙𝙨: The authors found these lipids are crucial for mRNA escape from endosomes, becoming positively charged in acidic environments. They explored enzyme-catalyzed synthesis to optimize their performance. 𝙋𝙝𝙤𝙨𝙥𝙝𝙤𝙡𝙞𝙥𝙞𝙙𝙨: Serving as the backbone of LNPs, these lipids ensure stability. The authors used microfluidic mixing to refine their composition. 𝘾𝙝𝙤𝙡𝙚𝙨𝙩𝙚𝙧𝙤𝙡: This component enhances membrane fusion and stability. The study explored various cholesterol structures to improve delivery efficiency. 𝙋𝙀𝙂-𝙇𝙞𝙥𝙞𝙙𝙨: These lipids help LNPs evade the immune system, prolonging circulation time for more effective delivery. 𝙎𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙚-𝘼𝙘𝙩𝙞𝙫𝙞𝙩𝙮 𝙍𝙚𝙡𝙖𝙩𝙞𝙤𝙣𝙨𝙝𝙞𝙥𝙨: Understanding these relationships is vital for designing effective LNPs. Techniques like barcoding were utilized for high-throughput profiling. 𝙁𝙪𝙩𝙪𝙧𝙚 𝙋𝙧𝙤𝙨𝙥𝙚𝙘𝙩𝙨: The authors found potential for LNPs to target tissues beyond the liver, expanding therapeutic possibilities. ----------------------------------------------------- Check out the full article to discover how these insights can enhance your work in biopharma! #Biopharma #Innovation #LipidNanoparticles #LNPs #mRNA #DrugDelivery #GeneTherapy _________________________________________________________________________ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭.   TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m   ⏭ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 lipid nanoparticles 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

❄️ 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗟𝗶𝗽𝗼𝘀𝗼𝗺𝗲 𝗦𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆: 𝗧𝗵𝗲 𝗥𝗼𝗹𝗲 𝗼𝗳 𝗖𝗿𝘆𝗼𝗽𝗿𝗼𝘁𝗲𝗰𝘁𝗮𝗻𝘁𝘀 ❄️ 🔵 Cryoprotectants (#CPAs) are vital in liposomal formulations, significantly boosting their stability and functional properties during and after freezing. These chemical agents lower the freezing point of water, acting much like "antifreeze" in other contexts. 🔵 Typically, a concentration of 5% to 15% cryoprotectant is sufficient to ensure a substantial portion of isolated cells survive freezing and thawing, even from liquid nitrogen temperatures. As temperatures drop, ice crystals form and squeeze cells into smaller pockets of unfrozen liquid. With cryoprotectants, these pockets are larger, reducing the risk of mechanical freezing injury and damage from high salt concentrations. 🔵 CPAs are categorized into two main types: membrane-permeating and non-membrane-permeating. 💠 𝗕𝘂𝘁 𝗵𝗲𝗿𝗲’𝘀 𝗮 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻: Which type of CPA do you find better suited for lab-scale liposome production? And what about large-scale manufacturing? 👇 Share your experiences below! 👇 #liposome #lipidnanoparticle #drugdelivery #drugdevelopment #biopharma #biotechnology #pharmaindustry 📑 Image source: Boafo, George Frimpong, et al. "The role of cryoprotective agents in liposome stabilization and preservation." International journal of molecular sciences 23.20 (2022): 12487.

𝘿𝙞𝙙 𝙮𝙤𝙪 𝙠𝙣𝙤𝙬 𝙩𝙝𝙖𝙩 𝙩𝙝𝙚 𝙧𝙞𝙜𝙝𝙩 𝙙𝙚𝙨𝙞𝙜𝙣 𝙥𝙖𝙧𝙖𝙢𝙚𝙩𝙚𝙧𝙨 𝙘𝙖𝙣 𝙚𝙣𝙝𝙖𝙣𝙘𝙚 𝙙𝙧𝙪𝙜 𝙙𝙚𝙡𝙞𝙫𝙚𝙧𝙮 𝙚𝙛𝙛𝙞𝙘𝙞𝙚𝙣𝙘𝙮? 🔬💊 Optimizing lipid nanoparticle (#LNP) formulations hinges on understanding and fine-tuning critical design parameters. Let's examine the key factors that influence LNP efficacy. 1️⃣ 𝗦𝗶𝘇𝗲 & 𝗣𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗖𝗼𝗻𝗰𝗲𝗻𝘁𝗿𝗮𝘁𝗶𝗼𝗻📏 ↳Optimal range: 50-200 nm ↳Key metric: Polydispersity Index (PDI) The size facilitates efficient cellular uptake while minimizing rapid clearance from the bloodstream. A low polydispersity index (#PDI) is crucial for uniformity in size, which can enhance the predictability of drug delivery. 2️⃣ 𝗠𝗼𝗿𝗽𝗵𝗼𝗹𝗼𝗴𝘆 🔷 ↳ Shapes include spherical, rod-like, star and even cubic or hexagonal structures ↳ Impacts cellular uptake and drug release Each morphology has a distinct impact on cellular uptake and drug release kinetics. For example, an exciting new research has introduced 𝗹𝗶𝗽𝗶𝗱 𝗻𝗮𝗻𝗼𝘀𝘁𝗮𝗿𝘀 (#LNSs), a novel star-shaped LNP variant. LNSs have shown 📈 cellular uptake and tumor accumulation compared to their spherical counterparts making morphology a vital consideration in formulation design. (https://lnkd.in/ehTj9fA6) 3️⃣ 𝗗𝗿𝘂𝗴 𝗘𝗻𝗰𝗮𝗽𝘀𝘂𝗹𝗮𝘁𝗶𝗼𝗻💊 Encapsulation efficiency is a crucial metric that indicates how much of the active drug is successfully loaded into the LNPs. Achieving an EE% greater than 90% is often a target for many applications, as higher efficiency can lead to better therapeutic outcomes and reduced side effects. 4️⃣ 𝗦𝘂𝗿𝗳𝗮𝗰𝗲 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 🧪 ↳ Zeta potential: Typically ranging from -10 to +10 mV, it affects colloidal stability and cellular uptake. ↳ Surface modifications: PEGylation or the addition of targeting ligands can enhance circulation time and specificity. ↳ Surface charge: Positive charges often promote cellular uptake but may also increase non-specific interactions. --------------------------------------- These properties can make or break an LNP formulation. Interestingly, changes as small as 1% in lipid composition can significantly alter LNP behavior. Interested in learning more about the latest advancements in lipid nanoparticles? Follow our page for updates! 🔔 #Biopharma #DrugDelivery #LipidNanoparticles #LNPs

𝙉𝙤𝙩 𝙖𝙡𝙡 𝙨𝙝𝙖𝙠𝙚𝙨 𝙖𝙧𝙚 𝙘𝙧𝙚𝙖𝙩𝙚𝙙 𝙚𝙦𝙪𝙖𝙡𝙡𝙮—𝙚𝙨𝙥𝙚𝙘𝙞𝙖𝙡𝙡𝙮 𝙬𝙝𝙚𝙣 𝙞𝙩 𝙘𝙤𝙢𝙚𝙨 𝙩𝙤 𝙡𝙞𝙥𝙞𝙙 𝙣𝙖𝙣𝙤𝙥𝙖𝙧𝙩𝙞𝙘𝙡𝙚𝙨 (#𝙇𝙉𝙋𝙨)!🥤 Have you ever wondered how adjusting lipid composition and mixing methods can enhance drug delivery? 🤔 Recent study published in 𝘈𝘊𝘚 𝘕𝘢𝘯𝘰, authored by a group of researchers from Roche Innovation Center Basel explores this important topic. Let’s break it down: ↳ Non-ionizable lipids are crucial for optimizing LNP structure 🧪 ↳ Mixing methods significantly alter particle characteristics 🔄 ↳ Techniques such as #CryoTEM and #SAXS provide in-depth analysis of LNP morphology🔍 --------------------------------------- 🔑 𝗞𝗲𝘆 𝗳𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 1️⃣ Lipid composition directly influences LNP morphology and stability. 2️⃣ Different mixing techniques lead to varied internal structures. 3️⃣ Higher non-ionizable lipid content = more stable formulations. 4️⃣ Ethanol injection yields smaller, more uniform particles. 5️⃣ T-tube mixing creates larger, more diverse structures. 6️⃣ SAXS provides detailed insights into LNP organization. 𝙏𝙝𝙚 𝙖𝙪𝙩𝙝𝙤𝙧𝙨 𝙖𝙡𝙨𝙤 𝙙𝙞𝙨𝙘𝙤𝙫𝙚𝙧𝙚𝙙: ↳ Non-ionizable lipids impact LNP size and shape. ↳ Mixing method affects internal nanostructure. ↳ Ethanol injection produces smaller, more homogeneous particles. ↳ T-tube mixing results in larger, more varied structures. ↳ SAXS reveals intricate details of LNP internal organization. ----------------------------------------- These insights are essential for improving drug delivery systems! So, which lipid strategy do you think will lead to the next breakthrough in LNP technology? Let’s discuss in the comments! #LipidNanoparticles #DrugDelivery #BiopharmaInnovation #NanoTechnology #SAXS #LNPs #CryoTEM _________________________________________________________________________ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭.   TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m   ⏭ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 lipid nanoparticles 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

🔵 Nanoparticle synthesis can be broadly categorized into two main approaches: 𝗯𝗼𝘁𝘁𝗼𝗺-𝘂𝗽 𝗮𝗻𝗱 𝘁𝗼𝗽-𝗱𝗼𝘄𝗻! 🔵 𝗧𝗵𝗲 𝗯𝗼𝘁𝘁𝗼𝗺-𝘂𝗽 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 involves the nucleation of atomic-sized materials into nanoparticles through methods like gas phase synthesis, block copolymer synthesis, the Turkeyvich method, and microbial synthesis. 🔵 In contrast, 𝘁𝗵𝗲 𝘁𝗼𝗽-𝗱𝗼𝘄𝗻 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 breaks down bulk materials into nanosized fragments using techniques such as milling, spark ablation, and laser ablation. 🔵 When it comes to Lipid Nanoparticles (#LNPs), the synthesis typically follows a wet chemistry bottom-up approach, owing to their unique colloidal structure! 🔵 The choice of synthesis method is critical, as it directly affects the LNPs' physicochemical properties, drug loading efficiency, stability, and behavior in vivo. Each synthesis method produces nanoparticles with specific characteristics that significantly impact their performance in therapeutic applications. ------------------------------------- 🤓 Which of these techniques have you used in your work? Share your experience in the comments! 📚 Source: Mehta, Meenu, et al. "Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development." ACS Materials Au 3.6 (2023): 600-619. #lipidnanoparticle #LNP #nanoparticle #drugdelivery #drugdiscovery #biotechnology #biopharmaindustry #genedelivery

Lipid Nanoparticle (#LNP) technology is making a significant impact in the biopharma landscape, with 29 approved LNP-based drugs transforming treatment approaches now. Remember when we first heard about RNAi therapeutics? Fast forward to today, and we have Alnylam Pharmaceuticals Onpattro®—the first FDA-approved LNP-based RNAi drug— treatment for hereditary ATTR amyloidosis. 🎉 But Onpattro is just the beginning. What makes LNPs so transformative? Their versatility and precision in drug delivery have opened doors to treating a wide range of diseases. Let’s break down the diverse applications of LNPs: • 🎗️ 𝘾𝙖𝙣𝙘𝙚𝙧 𝙏𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩𝙨 (12 𝙙𝙧𝙪𝙜𝙨) • 🦠 𝘼𝙣𝙩𝙞𝙛𝙪𝙣𝙜𝙖𝙡 𝙏𝙝𝙚𝙧𝙖𝙥𝙞𝙚𝙨 (4 𝙙𝙧𝙪𝙜𝙨) • 💉 𝙢𝙍𝙉𝘼 𝙑𝙖𝙘𝙘𝙞𝙣𝙚𝙨 (2 𝙙𝙧𝙪𝙜𝙨) • 🦠 𝙑𝙞𝙧𝙖𝙡 𝙑𝙖𝙘𝙘𝙞𝙣𝙚𝙨 (2 𝙙𝙧𝙪𝙜𝙨) • 💊 𝘼𝙣𝙖𝙡𝙜𝙚𝙨𝙞𝙘𝙨 (3 𝙙𝙧𝙪𝙜𝙨) • 🛡️ 𝙄𝙢𝙢𝙪𝙣𝙤𝙨𝙪𝙥𝙥𝙧𝙚𝙨𝙨𝙖𝙣𝙩𝙨 (2 𝙙𝙧𝙪𝙜𝙨) • 🫁 𝙍𝙚𝙨𝙥𝙞𝙧𝙖𝙩𝙤𝙧𝙮 𝘾𝙖𝙧𝙚 (1 𝙙𝙧𝙪𝙜) • 🧪 𝙃𝙤𝙧𝙢𝙤𝙣𝙖𝙡 𝙏𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 (1 𝙙𝙧𝙪𝙜) • 🩸 𝘼𝙣𝙩𝙞𝙝𝙚𝙢𝙤𝙥𝙝𝙞𝙡𝙞𝙘 𝘼𝙜𝙚𝙣𝙩 (1 𝙙𝙧𝙪𝙜) • 🧬 𝙍𝙉𝘼𝙞 𝙏𝙝𝙚𝙧𝙖𝙥𝙚𝙪𝙩𝙞𝙘 (1 𝙙𝙧𝙪𝙜) From managing chronic pain to fine-tuning immune responses, LNPs continue to surprise us with their capabilities. 𝘈𝘳𝘦 𝘸𝘦 𝘨𝘰𝘪𝘯𝘨 𝘵𝘰 𝘴𝘦𝘦 𝘮𝘰𝘳𝘦 𝘢𝘱𝘱𝘳𝘰𝘷𝘢𝘭𝘴 𝘵𝘩𝘪𝘴 𝘺𝘦𝘢𝘳? 💡 For those in drug development: What other therapeutic areas do you see benefiting from LNP technology? How can we address current challenges to enhance its application? #LipidNanoparticles #DrugDelivery #Biotechnology #PharmaceuticalInnovation #RNAi #CancerTherapy #RareDiseases #Biopharma #PrecisionMedicine

What if we told you that a tiny change in PEG levels could lead to major consequences for drug delivery? 🤔 🚀 The latest research provides some exciting clues! 🌟 Balancing PEG levels is essential for optimizing #liposome stability and minimizing antibody-induced destabilization. A just published article examined liposomes with grafted poly(ethylene glycol) (#PEG) and their susceptibility to destabilization by anti-PEG antibodies. ----------------------------------- 📍 𝗦𝘂𝗺𝗺𝗮𝗿𝘆 𝗮𝗻𝗱 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: 🔸𝙋𝙀𝙂𝙮𝙡𝙖𝙩𝙞𝙤𝙣: The authors explored how attaching PEG to liposomes enhances stability and circulation time. 🧬 🔸𝘿𝙚𝙨𝙩𝙖𝙗𝙞𝙡𝙞𝙯𝙖𝙩𝙞𝙤𝙣: They discovered that even low levels of PEG can lead to destabilization in the presence of anti-PEG antibodies. ⚠️ 🔸𝙃𝙮𝙙𝙧𝙖𝙩𝙞𝙤𝙣 𝙇𝙖𝙮𝙚𝙧: The study highlighted the importance of the hydration layer formed by PEG in maintaining liposome stability.💧 🔸𝘼𝙣𝙩𝙞𝙗𝙤𝙙𝙮 𝙄𝙣𝙩𝙚𝙧𝙖𝙘𝙩𝙞𝙤𝙣: Researchers found that anti-PEG antibodies can bind to PEGylated liposomes, impacting their therapeutic effectiveness. 🛡️ 🔸𝙏𝙝𝙚𝙧𝙢𝙤𝙙𝙮𝙣𝙖𝙢𝙞𝙘 𝙎𝙩𝙖𝙗𝙞𝙡𝙞𝙩𝙮: The authors examined how stability varies with PEG concentration, affecting liposome compressibility and hydration. 📈 🔸𝘽𝙞𝙤𝙡𝙤𝙜𝙞𝙘𝙖𝙡 𝙄𝙢𝙥𝙡𝙞𝙘𝙖𝙩𝙞𝙤𝙣𝙨: Understanding these interactions is crucial for advancing drug delivery systems. 💊 ---------------------------------------- Interested in how this impacts drug delivery? Check out the full study down below in the comments section! 🔍 #Liposomes #PEGylation #Biopharma #DrugDelivery #Innovation #Antibodies #Research _________________________________________________________________________ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭.   TechnoPharmaSphere LLC. Biopharm Consultant and CRO https://lnkd.in/d_q6PUF https://lnkd.in/gy2zmS5m   ⏭ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 liposome 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

💄𝗠𝗮𝗿𝗸𝗲𝘁𝗲𝗱 𝗟𝗶𝗽𝗼𝘀𝗼𝗺𝗲 𝗖𝗼𝘀𝗺𝗲𝘁𝗶𝗰 𝗣𝗿𝗼𝗱𝘂𝗰𝘁𝘀: 𝗔 𝗦𝘂𝗺𝗺𝗮𝗿𝘆 𝗼𝗳 𝗮 𝗗𝗶𝘃𝗲𝗿𝘀𝗲 𝗣𝗹𝗮𝘆𝗴𝗿𝗼𝘂𝗻𝗱🧪 🔵 The cosmetics industry was among the first to embrace nanotechnology in product development, leveraging liposomal formulations for enhanced stability, efficacy, and ingredient penetration! 🔵 Since 𝗗𝗶𝗼𝗿 introduced Capture in 1986, featuring thymus extract, #collagen, elastin #peptides, and hyaluronic acid in soya lecithin #liposomes, many brands have followed suit! Estée Lauder's Advanced Night Repair and L'Oréal's Revitalift Double Lifting are notable examples. These innovations highlight the industry's commitment to integrating advanced #science for better #skincare solutions! 🔵 Let's review a summary of liposome-based products in the market! Share your thoughts if you use them or add others to the list! #Nanotechnology #Cosmetics #Innovation #LiposomalFormulations #Skincare #BiotechInBeauty #LNP #lipidnanoparticles #biomaterial #sustainability #personalcare