🧠 #ClinicalChallenge #hematology #meded Which of the following scenarios would be an appropriate setting for use of recombinant ADAMTS13? A. Hereditary thrombotic thrombocytopenic purpura (TTP) in a patient who has become pregnant B. Immune TTP in a Jehovah's Witness who has indicated they cannot accept plasma C. Immune TTP that is refractory to multiple other therapies, such as plasma exchange, prednisone, rituximab, and caplacizumab D. Any of the above 👇Please add your answer to the comments.
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Clinicians trust UpToDate® to make the best care decisions and stay abreast of contemporary standards in the workflow and on-the-go. UpToDate is the only resource associated with improved patient outcomes and hospital performance. Every day, around the world, clinicians view topics covering 25 specialties over 1.5 million times.
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A cohort study including over 3,300 pregnant women exposed to buprenorphine with naloxone in the first trimester reported that maternal and neonatal outcomes were similar to or more favorable than those in a control group exposed primarily to buprenorphine alone, supporting the safety and efficacy of the combination product in pregnancy. We choose medications for opioid use disorder in pregnancy based on patient request after reviewing the risks and benefits of all options. Find out What's New in #obstetrics: https://ow.ly/hygx50TrmjC #ClinicalUpdates #meded
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The answer to yesterday’s #ClinicalChallenge question is: B. Ketamine and its S-enantiomer esketamine are NMDA receptor antagonists and act on the AMPA receptor; both receptors are involved in glutamate neurotransmission. They also activate opioid receptors. Nevertheless, the precise antidepressant mechanism is unknown. Both ketamine and esketamine have demonstrated efficacy for treatment-resistant depression in adults. A randomized controlled trial recently demonstrated efficacy of adjunctive esketamine for adolescents hospitalized with major depression and suicidal ideation, although its use for pediatric depression remains investigational. View the related What's New topic in #UpToDate: https://ow.ly/8MfE50TEfeq #psychiatry #meded
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#Pharmacists: the trusted hub of patient care. Integrating them into #healthcare teams boosts patient outcomes and combats burnout. Our Expert Insight by Christian Hartman, PharmD, MBA, FSMSO explores how to equip them for success! 🌟 https://ow.ly/A1tL50TrPfB #PharmacyIntegration #HealthcareExcellence #PatientSafety
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🧠 #ClinicalChallenge #psychiatry #meded The antidepressant effects of ketamine and esketamine are thought to involve interactions with several receptors.
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Suicide stigma hinders crucial conversations. Healthcare leaders can drive change by equipping clinicians with the right tools and support. Let’s work together to make #mentalhealth a priority and provide the care our communities deserve. https://ow.ly/iR4850TqkQ1 #MentalHealthMatters
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In a study of over 680 patients with factor XI deficiency, 42 had severe deficiency (factor XI activity ≤1 percent), and of those, seven had a factor XI inhibitor (30 percent). Six were homozygous for the F11 Glu135stop variant and all had been exposed to exogenous factor XI. These findings suggest the avoidance of exposure to exogenous factor XI, when possible, for individuals with severe factor XI deficiency and known homozygosity for this variant. Discover What's New in #hematology: https://ow.ly/IPJc50Trm5n #ClinicalUpdates #meded
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The FDA has approved Miplyffa (arimoclomol) oral capsules in combination with miglustat for the treatment of neurological manifestations of Niemann-Pick disease type C in adults and pediatric patients 2 years and older. For all the latest #DrugNews, check out our drug referential resource: https://ow.ly/tz7f50TA713 #Pharmacy #Medication
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Revolutionizing #healthcare in Greece! 🇬🇷 The Greek National Telemedicine Network offers vital access via #telemedicine to remote islands and villages. With real-time consultations and #clinicaldecisionsupport, we're enhancing healthcare equity and outcomes. Learn more: https://ow.ly/WRuR50TALtt #telehealth #HealthcareInnovation Dextera Consulting