Our research enterprise has struggled with how to characterize participants in research studies and subsequent application of the results to real world populations. A group of editors of biomedical journals announced new practices for using race, ethnicity, and ancestry descriptors in genomics research (https://lnkd.in/dJSUZSrs). Their position was influenced by a 2023 report of a committee of the U.S. National Academy of Sciences was tasked with developing a framework on the use of population descriptors in genetics and genomics research (https://lnkd.in/dkS8uEr9). After a thorough review and discussion of terms used in genetic and genomic research, the committee proposes 13 recommendations and provide a decision tree for using population descriptors by different genomic study types.
The committee also emphasized the importance of qualitatively and quantitatively measuring the environment to more completely understand health and disease phenotypes which result from complex interactions between gene – environment interactions. Environment is broadly defined in the committee’s view as social conditions (essentially social determinants of health) and built or physical factors (land use, green spaces, pollution, and among others). Their definition includes nutrition and the behaviors which affect health. Our teams have not only expressly supported this more comprehensive assessment of environment (PMIDs: 16277761, 19040372, 28300226, and 24363221) but designed and conducted nutrition intervention studies that attempted to more completely define participants genetic makeup and environment (PMIDs: 24879315, 24760553, 29368422, 34099811).
Vydiant has developed the OneHealth ecosystem of healthware applications that summarize lifestyle factors that affect health and conditions (OneHealth Pro - https://lnkd.in/dnk2eVrm) and OneHealth Go (iOS) that captures dietary, physical, social, and stress patterns of individuals. Identification of specific lifestyle, environmental, social, behavioral and genetic factors will help provide a more complete understanding of health and disease trajectories in individuals.
#Vydiant #precisionhealth #precisionmedicine #OneHealthPro #OneHealthGo