Expansion Therapeutics is a private well-funded biotechnology company focusing on developing transformative oral medicines for devastating RNA-mediated diseases. Expansion is seeking a highly motivated stem-cell biologist to play a key role in advancing the cross-functional drug discovery & development efforts. This position will be responsible for leading all stem-cell based in vitro disease modeling and assay development efforts and will be based in Expansion’s Cambridge, MA location.
Title, salary, and reporting structure will be commensurate with experience.
Accountabilities & Responsibilities
Establish core stem cell capabilities by culturing, expanding, and banking multiple pluripotent stem cell lines.
Differentiate healthy donor and patient derived iPSCs to cardiomyocytes and neurons, as applicable to disease areas of interest.
Establish QC criteria, reproducibility, and robust consistency to scale up and develop iPS-derived cells to support industry-standard molecular, biochemical, and image-based assays using qPCR, ELISA, and/or flow cytometry, and high-content microscopy/imaging technologies.
Perform non-viral delivery of DNA and RNA oligonucleotides (ASOs, siRNAs, Anti-sense probes) into iPS-derived or other mammalian primary/immortal cells.
Develop, optimize protocols, and support generation of standard operating procedures (SOPs).
Support upkeep and maintenance of laboratory equipment.
Maintain detailed, organized records of experimental data and analysis.
Interpret and present data regularly in both oral and written formats.
Collaborate with and train scientists and colleagues across programs.
Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.
Requirements
Requirements:Proven Experience, Skills, and Education:
PhD/Masters’ degree in a relevant biological field with hands-on 3-5-years of industry experience of iPS cell-based assay development and implementation.
Proven expertise in FISH and other immunofluorescence based cellular assays employing iPS-differentiated cells, confocal-microscopic imaging, and image analysis is a must.
Extensive experience in iPSC differentiation to cardiomyocyte lineages is highly valued.
Additional experience in iPSC differentiation to skeletal muscle and/or neuronal lineages will be appreciated.
Knowledge of RNA-mediated diseases and nucleotide-repeat-expansion disorders will be highly valued.
Attributes
Outstanding written and verbal communication skills
Ability to work independently, effectively collaborate, and exhibit high standards of lab citizenship in a fast-paced small-biotech team environment.
Passionate, self-motivated, individual contributor and critical thinker.
Success-oriented individual with relentless drive and ownership for advancing programs in a fast-paced environment
Contribute to the company culture with a team and collaborative spirit.
Expansion Therapeutics fosters an inclusive company culture that values diverse talent, backgrounds, and experiences. We are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other legally protected categories.
Seniority level
Mid-Senior level
Employment type
Full-time
Job function
Research, Analyst, and Information Technology
Industries
Biotechnology Research
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