Summary We are seeking an experienced Scientist to join our Discovery organization in Cambridge. This opportunity is for a person who strives to innovate, is never satisfied with routines, and has a strong heart for ARTBIO’s mission. A self-starter and innovator, you will be part of a cross-function team to spearhead key programs from our internal and partnered Discovery portfolio as well as support the build of the Early Discovery Biology disciplines at ARTBIO-Cambridge. MA in the USA. Responsibilities
- Lead, design, and execute cell-based studies to support identification and validation of novel targets as well as the advancement of drug discovery projects from hit discovery through IND
- Serve as internal champion for a target program, developing subject matter expertise and advising on criteria for development candidate nomination
- Develop functional assays to enable SAR for internal and partnered programs
- Demonstrate proficiency in mammalian cell line engineering, flow cytometry, and biochemical analysis of signaling pathways
- Develop innovative plate-based complementation, target engagement, and reporter activity assays to drive optimal parameters of radiopharmaceuticals
- Independently design and execute cell-based experiments and share key findings/path forward with internal/external project teams and senior management
- Manage internal and external project scientists to advance multiple small molecule drug discovery programs
- Analyze experimental results, brainstorm and troubleshoot findings thoughtfully and proactively
- Work seamlessly in matrixed environment to ensure technical support across programs
- Multi-task and collaborate effectively with other scientists and research associates to accomplish goals on tight timelines. Ability to navigate in a start-up environment and adapt in the ‘unknown’
- Maintain compliance with lab documentation to enable collaboration among multinational project teams
- PhD in Biology or related discipline, with 2-4 years of industrial experience, or equivalent
- Background in cancer biology with experience and quantitative impact using cell biology techniques to enable discovery biology
- Deep expertise in mammalian cell culture is required; proficiency and independence with core techniques such as Western blotting, CRISPR (KO/KI), flow cytometry, phenotypic assays are also essential
- Demonstrated success in development, optimization and execution of quantitative cellular assays to support small molecule drug discovery
- Previous experience with AlphaLISA, TR-FRET, NanoBRET, HiBit, CETSA, ternary complex formation assays preferred
- Strong management and mentorship skills with history of advancing the careers of direct reports
- Excellent organizational, communication, multi-tasking and collaboration skills
- Outstanding problem-solver, driven by innovative approaches, and comfortable working in a fast-paced startup environment
- Focus on the “we” rather than the “me”
- Motivated by patients, passionate about our company culture, inclusive and respectful of all colleagues
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Seniority level
Not Applicable -
Employment type
Full-time -
Job function
Research, Analyst, and Information Technology -
Industries
Biotechnology Research
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