Scientist II, Discovery Biology

Summary We are seeking an experienced Scientist to join our Discovery organization in Cambridge. This opportunity is for a person who strives to innovate, is never satisfied with routines, and has a strong heart for ARTBIO’s mission. A self-starter and innovator, you will be part of a cross-function team to spearhead key programs from our internal and partnered Discovery portfolio as well as support the build of the Early Discovery Biology disciplines at ARTBIO-Cambridge. MA in the USA. Responsibilities

• Lead, design, and execute cell-based studies to support identification and validation of novel targets as well as the advancement of drug discovery projects from hit discovery through IND
• Serve as internal champion for a target program, developing subject matter expertise and advising on criteria for development candidate nomination
• Develop functional assays to enable SAR for internal and partnered programs
• Demonstrate proficiency in mammalian cell line engineering, flow cytometry, and biochemical analysis of signaling pathways
• Develop innovative plate-based complementation, target engagement, and reporter activity assays to drive optimal parameters of radiopharmaceuticals
• Independently design and execute cell-based experiments and share key findings/path forward with internal/external project teams and senior management
• Manage internal and external project scientists to advance multiple small molecule drug discovery programs
• Analyze experimental results, brainstorm and troubleshoot findings thoughtfully and proactively
• Work seamlessly in matrixed environment to ensure technical support across programs
• Multi-task and collaborate effectively with other scientists and research associates to accomplish goals on tight timelines. Ability to navigate in a start-up environment and adapt in the ‘unknown’
• Maintain compliance with lab documentation to enable collaboration among multinational project teams
  
  
  

Qualifications

• PhD in Biology or related discipline, with 2-4 years of industrial experience, or equivalent
• Background in cancer biology with experience and quantitative impact using cell biology techniques to enable discovery biology
• Deep expertise in mammalian cell culture is required; proficiency and independence with core techniques such as Western blotting, CRISPR (KO/KI), flow cytometry, phenotypic assays are also essential
• Demonstrated success in development, optimization and execution of quantitative cellular assays to support small molecule drug discovery
• Previous experience with AlphaLISA, TR-FRET, NanoBRET, HiBit, CETSA, ternary complex formation assays preferred
• Strong management and mentorship skills with history of advancing the careers of direct reports
• Excellent organizational, communication, multi-tasking and collaboration skills
• Outstanding problem-solver, driven by innovative approaches, and comfortable working in a fast-paced startup environment
• Focus on the “we” rather than the “me”
• Motivated by patients, passionate about our company culture, inclusive and respectful of all colleagues
  
  
  

About Us ARTBIO is a clinical-stage radiopharmaceutical company redefining cancer care by creating a new class of alpha radioligand therapies (ARTs). The unique ARTBIO approach selects the optimal alpha-precursor isotope (212Pb) and tumor-specific targets to create therapeutics with the potential for highest efficacy and safety. The company's AlphaDirect™ technology, a first-of-its-kind 212Pb isolation method, enables a distributed manufacturing approach for the reliable production and delivery of ARTs. ARTBIO is advancing multiple pipeline programs with lead program AB001 currently in first in human trials. ARTBIO is shaped by a long-standing scientific legacy with nearly a century of pioneering work in radiation therapy conducted at the University of Oslo and Norway’s Radium Hospital. For more information, visit www.artbio.com, and follow us on LinkedIn and Twitter. As an emerging, global biotech with locations in Boston, Massachusetts, Basel, Switzerland, London, England and Oslo, Norway, we take advantage of diverse scientific depth and insights which makes ARTBIO a unique place to work. We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while at the same time raising the bar on clinical efficacy and duration. EEO Statement ARTBIO is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.