Treefrog Therapeutics is an innovative biotech aiming to bring cell therapies to millions of patients, thanks to C-Stem technology, which was developed to cultivate and differentiate stem cells on a large scale, a world 1st. Since its incorporation in 2018, Treefrog Therapeutics has raised more than € 74 million and is experiencing strong acceleration thanks to its over 130 froggies team including 10 in Boston.
Description of Position
At TREEFROG US site, this Senior Scientist will lead a team of stem cell biologists to support the pluripotent stem cell (PSC) expansion and differentiation efforts in the C-Stem capsule technology. A primary objective of this role will be the development and validation of novel methods to characterize and expand pluripotent stem cells for use in cell therapy applications, and to support efforts in scaled production of PSCs. This is a lab based position with management responsibilities for junior lab associates.
Main tasks
Working as part of the larger US research group, you will lead a small team to:
Perform routing culture and quality control of human PSCs.
Encapsulate and expand PSCs using the C-Stem capsule technology
Develops protocols for differentiating PSCs into multiple cell types
Develops novel methods for manipulating and analyzing PSCs during the expansion and differentiation process.
Other activities
As the iPS team leader at the US site, you will also be responsible for:
Coordinating and collaborating with the iPS platform team in France
Collaborating with other US TreeFrog teams to improve PSC performance in C-Stem
Evaluating and interacting with external partners to execute on new therapeutic programs
QUALIFICATIONS
PhD in cell/developmental biology or related field with postdoctoral training or 3-5 years of postdoctoral industry experience. Must be able to work in the United States.
SKILLS
Knowledge
Deep understanding of Pluripotent Stem Cell biology and cell differentiation
Expertise in one or more of the following areas of cell biology: cell metabolism, DNA damage repair, epigenetic gene regulation, early embryonic development, or cell:extracellular matrix interactions.
Expert knowledge in at least one disease area.
Know-how
Demonstrated experience with the culture and characterization of multiple pluripotent stem cell lines.
Technical proficiency in standard molecular characterization methods such as flow cytometry, immunocytochemistry, RNA analysis (Taqman, scRNAseq, etc), and standard plate-based assays.
Experience mentoring junior scientists and promoting their career development.
Mindset
Creative, flexible scientist that can thrive in change and interact with colleagues from multiple scientific disciplines.
Excellent documentation skills with a fine attention to detail.
Ability to work in a highly collaborative and matrixed team environment to deliver on common goals.
Work environment & conditions
Location : US TreeFrog site in Cambridge MA
Other aspects : Must be willing to work limited weekend hours as necessary
Seniority level
Associate
Employment type
Full-time
Job function
Research and Analyst
Industries
Biotechnology Research
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