ABHfilms’ Post

Congratulations to researchers from John Hopkins University and Johns Hopkins All Children's Hospital for their remarkable research on pulmonary hypertension (PAH) and its metabolic effects. The John Hopkins team utilized our #VERSA1100 to filter and prepare the tissue samples before conducting 𝗟𝗖-𝗠𝗦 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀, enabling precise sample handling through solid-phase extraction. Read about VERSA here: https://lnkd.in/gHsEHxrg Their method involved treating rodent models to mimic human PAH symptoms. Through this approach, they were able to extract tissue samples and analyze metabolic changes associated with the disease’s progression. Notably, they observed changes in tissue metabolite levels in addition to physical changes such as ventricular sizes. Interested in learning more? Check out the white paper/publication below: White paper: https://lnkd.in/gxQX9d9F Publication: https://lnkd.in/g5DAxP-M Authors: 𝗖𝗮𝘁𝗵𝗲𝗿𝗶𝗻𝗲 𝗘. 𝗦𝗶𝗺𝗽𝘀𝗼𝗻, Anjira S. Ambade,Robert Harlan MS,Aurelie ROUX, David Graham, 𝗡𝗲𝗮𝗹 𝗞𝗹𝗮𝘂𝗲𝗿, Tijana Tuhy, Todd Kolb, 𝗞𝗮𝗿𝘁𝗵𝗶𝗸 𝗦𝘂𝗿𝗲𝘀𝗵, Paul Hassoun, Rachel Damico #PulmonaryHypertension #PAH #JohnHopkins #SPE #SolidPhaseExtraction #LCMS #MassSpec

#Diabetic #wounds, often resistant to conventional treatments, pose serious health risks to millions of people worldwide. #Immune cells known as #macrophages, which are supposed to help, end up causing #inflammation instead, making it harder for the wound to heal properly and quickly. Now, researchers from the Icahn School of Medicine at Mount Sinai and The Ohio State University have designed a #regenerative medicine therapy to speed up diabetic wound repair. Using #lipid #nanoparticles loaded with #RNA encoding a signaling protein known as a #cytokine, the therapy targeted dysfunctional macrophages while simultaneously reducing inflammation in diabetic wounds. "In preclinical models, we basically showed the therapy's ability to reprogram pro-inflammatory macrophages into reparative ones, leading to improved wound healing outcomes," said Yizhou Dong, one of the scientists involved in this study. https://lnkd.in/gqVgtuP6 (Work funded by The National Institutes of Health)

#Characterization of #Adult #Patients with #Pilocytic #Astrocytoma with an Aggressive #Clinical #Course. Retrospective #Cross-Sectional Study. #Single #Center Experience A #researcharticle authored by ✍ Poluektov Yuri #Background: Pilocytic astrocytoma (PA) is a common tumor of the central nervous system and is considered a benign condition. However, in some cases PA can demonstrate aggressive clinical behavior. #Aim: To analyze and correlate factors leading to an aggressive course of disease in patients with PA. #Methods: As part of a retrospective study, medical records of adult patients (over 18 years of age) with a histological diagnosis of pilocytic astrocytoma were examined. #Results: 19 patients with signs of an aggressive course of the disease were identified. It was found that the age of the patients did not differ significantly between the groups... #Conclusion: A small percentage of PA are prone to an aggressive clinical course. One should be more wary of patients with a “benign” diagnosis... To get full-length article kindly go through the link https://lnkd.in/gZndU4zU We do accept #PPTs and #Video Articles to be publish within our Journal. You can send us your article to given email #Email: onlinescientificresearch@gmail.com

Defects in the renin–angiotensin system (RAS) can predict clinical outcomes in sepsis and may outperform traditional biomarkers such as lactate. With Laurence Busse Michael McCurdy Greg Martin and VICTAS collaborators we postulated that RAS dysfunction (elevated active renin, angiotensin 1-7 [Ang-(1-7)], and angiotensin-converting enzyme 2 (ACE2) activity with depressed Ang-II and ACE activity) would be associated with mortality in a cohort of septic patients. 103 biorepository samples from the Vitamin C, Thiamine and Steroids (VICTAS) in Sepsis trial were analyzed Wake Forest University Hypertension and Vascular Research Center under the guidance of Mark Chappell and Christopher Schaich, PhD, MS . Our results demonstrated that baseline serum active renin levels were strongly associated with mortality and a greater relative activation in circulating renin from day 0 to day 3 was associated with a higher risk of death. In addition, we performed a series of important experiments that help understand the mechanistic of the balance of ACE, ACE2, Ang II/Ang 1-7 and other elements of the RAAS axis. All of this is work in evolution and our hope is that it will lead to the production of an effective, accurate and precise bedside assay of renin and or Ang metabolites that allow for biomarker guided resuscitation, and choice of effective vasopressors. Atrium Health Wake Forest Baptist Wake Forest University School of Medicine Wake Forest University Full text:

#Glaucoma is one of the leading causes of visual impairment and blindness. In glaucoma patients, the fluid within the eye, known as aqueous humour, continuously flows, resulting in higher intraocular pressure (#IOP) for which long-term medication is required. However, current drugs can only slow disease progression rather than halt it completely, and their efficacy diminishes over time. Yet, the #PolyU research team has discovered the mechanism of IOP regulation, paving the way for novel treatment approaches for glaucoma, with the aspiration of preventing vision loss from this disease. The research led by Dr Samantha SHAN, Research Assistant Professor of the PolyU School of Optometry, focuses on gaining insights into the mechanisms of miR-17-92 cluster members and their effects on IOP. They found a way to repress the expression of a protein that reduces the outflow of aqueous humour and increases IOP, resulting in an approximately 73% increase in the outflow of aqueous humour. The research results play a crucial role in understanding the genetic and molecular mechanisms underlying diseases such as glaucoma, helping identify potential biomarkers, therapeutic targets and personalised treatment options, with far-reaching implications. Learn more: https://polyu.hk/HAAIQ #PolyUResearch #AqueousHumour #IntraocularPressure #EyeDisease #Treatment #EyeCare

#kidneydisease #research  #medicine #medicalsciences https://lnkd.in/gBraqraa Abstract Notable progress in basic, #translational and #clinical #nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection of kidney disease, disparities in access to care and variability in responses to existing and emerging therapies. Innovations in drug development, research technologies, tissue engineering and #regenerative #medicine have the potential to improve patient outcomes. Exciting prospects include the availability of new #drugs to slow or halt the progression of chronic kidney disease, the development of #bioartificial #kidneys that mimic healthy kidney functions, and tissue engineering techniques that could enable transplantable kidneys to be created from the cells of the recipient, removing the risk of rejection. Cell and gene therapies have the potential to be applied for kidney tissue regeneration and repair. In addition, about 30% of kidney disease cases are monogenic and could potentially be treated using these genetic medicine approaches. Systemic diseases that involve the kidney, such as diabetes mellitus and hypertension, might also be amenable to these treatments. Continued investment, communication, collaboration and translation of innovations are crucial to realize their full potential. In addition, increasing sophistication in exploring large datasets, implementation science, and qualitative methodologies will improve the ability to deliver transformational kidney health strategies.

Hypertrophic cardiomyopathy (HCM) is a cardiac disease in which several gene mutations affect its manifestation. HCM thickens heart walls and increases the risk of irregular heartbeats and sudden death. Affecting up to five in 1,000 people, it's the most common inherited cardiac disease and a leading cause of sudden death in young individuals. Despite the complexity of the disease, current approaches treat HCM as a single disease, resulting in less effective care. Enter SMASH-HCM, a €10 million EU project led by Tampere University, poised to revolutionize HCM management! SMASH-HCM develops a sophisticated digital twin – a digital replica of the heart and blood vessels, complemented by sympathetic nerve control and integrated with AI and clinical data. This advanced digital tool enhances risk assessment and enables tailored treatments for individual patients. Doctors gain improved diagnostics and can provide precise lifestyle advice. Moreover, the new tool supports healthcare, technology, and pharmaceutical industries by facilitating target discovery and cardiac safety testing. Ultimately, it promises superior treatments, outcomes, and global healthcare cost savings. 📸 Jonne Renvall / Tampere Uni #HCMawareness #DigitalHealth #PersonalizedMedicine #CardiologyInnovation #PatientCare #MedicalResearch #HealthTech #SMASHHCM

Disease-modifying therapies (DMTs) are a class of medications used in the treatment of multiple sclerosis (MS). These medications aim to modify or slow down the course of the disease, reduce the frequency and severity of relapses, and delay the progression of disability. The choice of DMT depends on various factors, including the type of MS, the patient's medical history, and individual preferences. It's best to discuss these options with your healthcare provider. #Biotech #MS #Multiplesclerosis #DMT #Disease #Modifying #Therapies #Neurodegenerative #Science #FDA

🧐Check out Brief Report: Neutrophil-to-Lymphocyte Ratio Predicts Early Neurological Deterioration after Endovascular Treatment in Patients with Ischemic Stroke 🎓by Prof. Dr. Lattanzi et al., from the Marche Polytechnic University, Italy. 📄Enjoy reading: https://lnkd.in/eGgQsjYx #cerebrovascular disease; #ischemicstroke; #neutrophils; #lymphocytes; #neutrophil-to-lymphocyte ratio

Osteolabs Publishes Real-World Data from 3,000 OsteoTest Samples Osteolabs GmbH has announced publication in Bone journal, showcasing real-world data from 3,000 OsteoTest patient samples. This study, conducted with GEOMAR, University Hospital Schleswig-Holstein, and UCL Great Ormond Street Hospital, is the first to report the application of their CIM technology in real-world clinical settings. The results highlight a strong correlation between CIM markers and metabolic bone diseases, reinforcing OsteoTest’s potential as a universal diagnostic tool for early osteoporosis detection. Read more here: https://lnkd.in/g5uQTMVw #osteolabs #osteoporosis #healthtech #diagnostics