Mohammad Vaziri’s Post

#kidneydisease #medicine #medicalscience https://lnkd.in/gBraqraa Abstract Notable progress in basic, #translational and #clinical #nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection of kidney disease, disparities in access to care and variability in responses to existing and emerging therapies. Innovations in drug development, research technologies, tissue engineering and regenerative medicine have the potential to improve patient outcomes. Exciting prospects include the availability of new drugs to slow or halt the progression of chronic kidney disease, the development of #bioartificial #kidneys that mimic healthy kidney functions, and tissue engineering techniques that could enable transplantable kidneys to be created from the cells of the recipient, removing the risk of rejection. Cell and gene therapies have the potential to be applied for kidney tissue regeneration and repair. In addition, about 30% of kidney disease cases are monogenic and could potentially be treated using these genetic medicine approaches. Systemic diseases that involve the kidney, such as diabetes mellitus and hypertension, might also be amenable to these treatments. Continued investment, communication, collaboration and translation of innovations are crucial to realize their full potential. In addition, increasing sophistication in exploring large datasets, implementation science, and qualitative methodologies will improve the ability to deliver transformational kidney health strategies.

#kidneydisease https://lnkd.in/gBraqraa Abstract Notable progress in basic, #translational and #clinical #nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection of kidney disease, disparities in access to care and variability in responses to existing and emerging therapies. Innovations in drug development, research technologies, tissue engineering and #regenerative #medicine have the potential to improve patient outcomes. Exciting prospects include the availability of new #drugs to slow or halt the progression of chronic kidney disease, the development of #bioartificial #kidneys that mimic healthy kidney functions, and tissue engineering techniques that could enable transplantable kidneys to be created from the cells of the recipient, removing the risk of rejection. Cell and gene therapies have the potential to be applied for kidney tissue regeneration and repair. In addition, about 30% of kidney disease cases are monogenic and could potentially be treated using these genetic medicine approaches. Systemic diseases that involve the kidney, such as diabetes mellitus and hypertension, might also be amenable to these treatments. Continued investment, communication, collaboration and translation of innovations are crucial to realize their full potential. In addition, increasing sophistication in exploring large datasets, implementation science, and qualitative methodologies will improve the ability to deliver transformational kidney health strategies.

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan The authors examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. - As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. - Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. - Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. -  These data suggest that anti-IL-11 therapy, which has a reassuring safety profile and is currently in early-stage clinical trials for fibroinflammatory diseases, is a potentially translatable approach for extending human healthspan and lifespan. https://lnkd.in/efbwFrAv #inflammation #ageing #science

In 2023, several research findings related to endometriosis have emerged. Some of the latest advancements include: 1. A study published in Science Translational Medicine found that endometriosis may be caused by a bacterial infection. This discovery could potentially lead to new treatments and a better understanding of the condition. 2. A global study revealed compelling evidence of a shared genetic basis for endometriosis and other types of pain seemingly unrelated to endometriosis. This finding could help researchers develop more targeted treatments for endometriosis. 3. A potential new treatment for endometriosis is being tested in a groundbreaking clinical trial involving 100 women in Edinburgh and London. The trial aims to assess whether the drug dichloroacetate helps relieve pain, which could be the first non-hormonal, non-surgical treatment for endometriosis. 4. Research has shown that pelvic floor therapy could be key to tackling endometriosis-induced pain. A 2021 study showed that incorporating pelvic floor therapy as part of a lifestyle could help women with deeply infiltrative endometriosis (DIE) – a type of endometriosis that can invade the pelvic cavity. These findings contribute to the ongoing research and development of new treatments and interventions for managing endometriosis, a condition that affects around 190 million women and girls globally. #EndometriosisAwareness #EndoWarrior #EndoStrong #EndoCommunity #EndoSupport #EndoSisters #EndoAdvocate #EndoLife #EndoAware #EndoFighter #EndoPain #EndoAwarenessMonth #EndoResearch #EndoHealth #EndoAwarenessCampaign

Thrilled to share the results of our latest study entitled "#Neurosteroid Levels in #GBA Mutated and Non-Mutated #Parkinson’s Disease: A Possible Factor Influencing Clinical Phenotype?" just published in Biomolecules MDPI. This pilot study provides the first observation of changes in #neurosteroid peripheral levels in #GBAPD representing a great collaboration between AUSL Reggio Emilia #IRCCS_RE and Università degli Studi di Modena e Reggio Emilia. Some key points: - we assessed neurosteroids’ serum levels in a cohort of GBA-PD compared with matched cohorts of consecutive non-mutated PD patients and healthy subjects with (GBA-HC) and without (NM-HC) GBA mutations. - 22 GBA-PD, 22 NM-PD, 14 GBA-HC and 15 HC were included. - most of the serum neurosteroids were reduced in both GBA-PD and NM-PD compared to the respective control cohorts, except for 5α-dihydroprogesterone. - Allopregnanolone was the only neurosteroid significantly lower in NM-PD compared to GBA-PD patients. - interestingly in GBA-PD, allopregnanolone, and pregnanolone levels correlated with a more severe MDS-UPDRS part-III, while Allopregnanolone levels also negatively correlated with MoCA scores, and pregnanolone levels correlated with more pronounced bradykinesia. Many thanks to all the co-authors in particular Giuseppe Biagini, Chiara Lucchi, franco valzania, Alessio di Fonzo, Edoardo Monfrini, Sara Grisanti, Valentina Fioravanti, Giulia Di Rauso and Jessica Rossi.

A pivotal 2024 study in Nature Medicine discusses the unexpected long-term consequences faced by those who received cadaveric pituitary-derived growth hormone (c-hGH) treatments between 1960 and 1980. The study suggests a heightened risk of developing early-onset Alzheimer’s disease due to exposure to amyloid beta protein, which can accumulate in the brain tissues and blood vessels. This discovery highlights the often overlooked long-term risks of early medical interventions and the sobering truth that we must be cautious of one-size-fits-all approaches due to each person’s uniqueness. It also underscores the importance of detailed health histories! For more details, you can read the full article from Nature Portfolio here: https://lnkd.in/gagW9epY

Dear Colleagues, Aging results from the cumulative dysfunction of the various organs and systems, with implications on morbidity and mortality. Immunosenescence is the remodeling of the immune system accompanying aging, characterized by the defects in immunocompetent capacity and tumor immunosurveillance, and inflammaging is a condition of low-grade inflammation, contributing to the onset and progression of age-related diseases. In the elderly, nutritional deficits and hormonal dysfunctions impact on the immune system. Complex interactions of metabolic and immunological pathways, as well as genetic and epigenetic regulation of defenses against oxidative damage and responses to stress, drive both senescence and inflammaging. The aim of this Special Issue is to collect the most recent preclinical and molecular research and the current concepts about the interconnected signals linking aging and immunosenescence as well as other homeostatic system dysfunctions in the elderly and their translational implications. Prof. Dr. Lia Ginaldi Guest Editor

Neurodegenerative diseases are characterized by synapse dysfunction and the aggregation of proteins in the brain. As the global population ages, the prevalence of these diseases increases. Though diseases such as #Alzheimers and #Parkinsons affect millions of people across the world, a comprehensive understanding of the mechanisms remains elusive. Much of the recent progress in research relies on collaborative efforts and data-sharing initiatives. Researchers worldwide from different fields must pool their data and findings to enhance our understanding of the underlying mechanisms, offering hope for more effective treatments and diagnostic methods. Read the full Technology Networks article: article: https://lnkd.in/edgWzR46

📢Raising star Paper Sharing: IL-6 signaling pathway differentiation for endometriosis and inflammatory diseases 👥 Authors: Ryan D. Castle (Ryan Castle) 🔑 Keywords: #Inflammation, interleukin-6, #endometriosis, #cytokines, #biomarkers, inflammatory diseases 🎯 "...This review proposes adjustments to research methodologies and stresses the importance of careful interpretation of inflammatory markers in IL-6-related research. Examples of differentiation issues are discussed across the topics of endometriosis and multiple inflammatory diseases. By addressing this methodological issue, researchers could potentially improve patient outcomes, enhance the efficacy of interventions, and contribute to public health advancements." 🔸 Academic editor: Giustino Varrassi 🔗 Read the full article: https://lnkd.in/gmpp-vuh

Amazing research! As mentioned in the article this can be used in the future as personalized medicine by using these Mini-guts to testing with different therapies prior to the patient even starting treatment thus as guides for the best treatment option for the patient. I believe they can also be used to test the gut microbiome within these mini-guts to attempt to find any potential association with a microbe causing these epigenetic changes within patients with CD. Determining if CD pathogenesis may be due to changes in gut microbiome in genetically predisposed individuals that cause the DNA methylation or histone acetylation or miRNA disturbance to MHC-1 transcription. The use of AI can help accelerate this type of research. 🧐 #biotechnology #bioinformatics #AI