ACTIV-H’s Post

🚀 Discover Innovative Drug Discovery Approach! Optimizing molecules for drug discovery is often a tedious and costly process. However, by implementing automation and miniaturization directly into biological assays, we can accelerate synthesis, save expensive reagents, and eliminate the need for extensive single-compound purification and handling. This innovative approach is commonly known as plate-based chemistry or direct-to-biology. In addition to classical small molecules, this method has been successfully applied to new modalities like PROTACs. At the upcoming EFMC-ISMC 2024, where we will showcase a proof-of-principle case study demonstrating automated reaction miniaturization of amide couplings, followed by direct biological readouts of unpurified reaction mixtures. 🌐Curious about the details? Visit our poster and schedule a meeting with our team for an in-depth discussion -> https://lnkd.in/excR7WYi #PlateBasedChemistry #LifeScienceChemistry #DrugDiscovery #EFMCISMC2024 #NUVISAN #ScienceCRO

🌟Fsp3: The Gold Standard in Drug-Likeness - Escaping from Flatland💊 🔍 Revisiting Game-Changing Concepts in Drug Discovery! 🔍 Excited to highlight "Fsp3: A new parameter for drug-likeness" published in 2020. Dive into how Fsp3 and enhanced 3D structures revolutionize medicinal chemistry, predicting molecular properties and aiding in drug discovery. Spirocycles are ready to take center stage in sp3-rich scaffolds. Perfect time to refresh your knowledge and explore innovative advancements! Source: Wenxiu Wei et al., Fsp3: A new parameter for drug-likeness https://lnkd.in/gZkKQ_uF https://lnkd.in/gmvwbU6F #DrugDiscovery #MedicinalChemistry #Fsp3 #Spirocycles #Innovation

The East Coast 2024 Medicinal Chemistry Strategy Meeting welcomes Curia's James LaRocque, a leader in High-Throughput Screening (HTS), for a session exploring how this technology is pushing the boundaries of drug discovery. Jim currently leads a team developing cutting-edge screening platforms at Curia. His expertise spans areas like cellular imaging and label-free screening, techniques poised to revolutionize how we tackle previously undruggable targets. Jim leads us for a deep dive into the future of HTS, where we'll explore: 🔹 Engineered vs. traditional assays 🔹 Cellular vs. Biochemical HTS approaches 🔹 The power of label-free HTS 🔹 Emerging screening methods and their impact 🔹 The role of computational modeling in focused library design 🔹 Leveraging HTS for broader lead optimization Get ready for a thought-provoking discussion on how HTS is changing the game in drug discovery! #MedicinalChemistry #HTS #DrugDiscovery #UndruggableTargets #JamesLaRocque #Curia #EastCoastScience

We are proud to be part of #MC4DD - a New EU consortium focused on the discovery and application of macrocycles in drug discovery. In the frame of this collaboration, 8 universities and 6 industry partners join forces to advance the science of macrocycles as drugs. More information about MC4DD: www.MC4DD.com Together with Serhiy Ryabukhin (Enamine Ltd. and UORSY (Ukrorgsyntez Ltd.) Enamine Germany will focus on the design and production of specific building blocks for further application in macrocycle construction. See more about our capabilities in the area of macrocycle synthesis: https://lnkd.in/eHSZq-5x Exciting chemistry is ahead! #DrugDiscovery #Macrocycles #UORSY #OrganicChemistry #MedicinalChemistry

🔬 BMCS 4th Synthesis in Drug Discovery and Development 2024 💻 Virtual Meeting 📅 June 4-5, 2024 ⏳ Registration Deadline: June 3, 2024 Join this event for a deep dive into the heart of drug discovery and development. This symposium will celebrate the crucial role of synthesis, highlighting the demand for high-quality clinical candidates and the innovative methods used to target less druggable biological targets. 🌟 Why Attend? ◼️ Discover the latest advancements in synthetic methodologies. ◼️ Learn about the introduction of novel bioisosteres. ◼️ Engage with leading experts in the field. ◼️ Don't miss this opportunity to enhance your medicinal chemist's toolbox and network with fellow researchers. 🔗 https://lnkd.in/ebTH8NiX #SDDD24 #DrugDiscovery #MedicinalChemistry #SyntheticMethods #VirtualSymposium

Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development https://lnkd.in/eb6YXrPy #subQ #subcutaneousinjections #injectables

Supercharge your research with CyberX-SAR—a game-changer that enhances efficiency by 100x. exploration of potential drug targets , obtain structure-activity relationships, and visualize molecular clusters effortlessly. Step into the future of medicinal chemistry with AI-driven insights! #AIinMedicine #drugdiscovery #medicinalchemistry #AIInsights #FutureofChemistry #aifordrugdiscovery #PharmaInnovation #AIAdvancements #DrugDesign #CyberAIDD

*Molecules of the Month - July Edition* This month, our MotM focuses on Target Protein Degradation and some of the medicinal chemistry approaches that are applied within this area of drug discovery. Read on to find out how LCC's proprietary linkers, virtual libraries and parallel synthesis capabilities can help accelerate you drug discovery efforts. 👇 #TargetProteinDegradation #Linkers #VirtualLibraries #DrugDiscovery

🔬 BMCS 4th Synthesis in Drug Discovery and Development 2024 💻 Virtual Meeting 📅 June 4-5, 2024 ⏳ Registration Deadline: June 3, 2024 Join this event for a deep dive into the heart of drug discovery and development. This symposium will celebrate the crucial role of synthesis, highlighting the demand for high-quality clinical candidates and the innovative methods used to target less druggable biological targets. 🌟 Why Attend? ◼️ Discover the latest advancements in synthetic methodologies. ◼️ Learn about the introduction of novel bioisosteres. ◼️ Engage with leading experts in the field. ◼️ Don't miss this opportunity to enhance your medicinal chemist's toolbox and network with fellow researchers. 🔗 https://lnkd.in/ebTH8NiX #SDDD24 #DrugDiscovery #MedicinalChemistry #SyntheticMethods #VirtualSymposium

Announcing the launch of CHI's 20th Annual Drug Discovery Chemistry: in San Diego April 2025! Check the website to view new as well as established, popular symposia and conference tracks. Consider submitting a proposal to speak. And of course SAVE THE DATE to attend! If you have speaker or topic suggestions, reach out to Tanuja Koppal and me. We look forward to programming, over the next two months, an exciting four days of the latest and greatest advancements in the design and discovery of small molecules (and some bigger molecules such as oral peptides) with therapeutic potential. #DrugDiscoveryChemistry #MedicinalChemistry