As shared by NCI, a meta-analysis my team and I prepared in early 2022 reviewed key data to conclude the following ➡️
Plain language summary:
Immune checkpoint inhibitors (ICI), atezolizumab and pembrolizumab, have received approval for patients with triple-negative breast cancer (TNBC) expressing PD-L1. Thus far, it has only been approved for patients with unresectable locally advanced or metastatic TNBC. With the IMpassion 130 and KEYNOTE-355 trials introducing the immunotherapy era for TNBC, ongoing trials have started exploring the outcomes of the ICIs in early-stage TNBC in combination. Recently, the ICIs have demonstrated positive efficacy outcomes in neoadjuvant settings. Both the ICIs have shown a safe profile in terms of adverse events. The recent advances made by clinical trials indicate promising results for early-stage and advanced/metastatic TNBC. However, there is a need to harmonize and explore biomarkers and endpoints in the ongoing clinical trials to enhance patient treatment protocols. As TNBC is an aggressive subtype, exploring beyond the PD-L1 positive subgroup is necessary to expand the target population receiving ICIs for TNBC.
Here is the full link of the study: https://lnkd.in/ejmYcqeQ
While immunotherapy has taken the center stage in many clinical paradigms, my current line of work focuses on the best treatment/practices to improve AE profiles as well.
#cancer #oncology #TNBC #breastcancer #research
Adding the immunotherapy drug pembrolizumab (Keytruda) to chemotherapy can help some people with advanced triple-negative breast cancer live longer. In a 2022 trial, survival improved among those whose tumors had high levels of the PD-L1 protein. http://spr.ly/6043X3shF #TNBCday
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