Aladdin Scientific’s Post

🧬 The Importance of Immunodetection Reagents & Substrates in Research 🧬 Immunodetection reagents and substrates are pivotal in the field of biomedical research. These tools enable the precise detection and quantification of proteins, facilitating breakthroughs in diagnostics, therapeutics, and disease understanding. From primary and secondary antibodies to chromogenic and chemiluminescent substrates, they play a crucial role in various assays like ELISA, Western blotting, and immunohistochemistry. Understanding and utilizing these reagents effectively can lead to significant advancements in medical science. #BiomedicalResearch #Immunodetection #HealthcareInnovation #LifeSciences #AladdinScientific Aladdin Scientific: https://lnkd.in/gmZe2sd7 Aladdin official：https://lnkd.in/gdZRkbhS

Evosep and Thermo Fisher Scientific have joined forces to take clinical proteomics to new heights. Their co-marketing agreement combines Evosep's cutting-edge sample separation technology with Thermo Fisher Scientific's state-of-the-art mass spectrometry instruments, promising groundbreaking advancements. Proteomics, with its comprehensive analysis of protein isoforms, offers insights into diseases and individual patient responses. This deeper understanding paves the way for targeted therapies, optimized treatment efficacy, drug discovery, and personalized medicine. Plasma proteomics, powered by liquid biopsy, accelerates drug discovery, identifies biomarkers for early disease detection, and supports personalized medicine. Single-cell proteomics provides a nuanced understanding of individual cell protein profiles, advancing precision medicine. #Proteomics #PrecisionMedicine #MassSpectrometry #FutureOfHealthcare #Healthcare Read more about this exciting development: https://lnkd.in/gZqbTM8W

Happy to share our recent paper where we compared different separation techniques for the isolation and enrichment of extracellular vesicles (EVs) from a clinically relevant 1mL sample of human plasma. Considering the fact that: (i) patient sample availability is a key barrier to translational research (with many biobanks storing samples of ~1,5mL or less) and (ii) there is a need for an easy, fast, not complicated and reproducible method that separates EVs, in this study we confirm and highlight size exclusion chromatography (SEC) as the most preferred method that would be suitable for widespread adoption in less EV-specialised labs for clinical biomarker identification studies. Well done to Stephen Robinson and the rest of the team! #extracellularvesicles #exosomes https://lnkd.in/eg8S8Mmp

Exciting study! 🌟 This latest research unveils the power of the new Thermo Scientific Stellar MS in rapidly translating large-scale biomarker discoveries into precise clinical assays. Key achievements include: - Handling extensive biomarker data. - Developing versatile assays with varied throughputs and peptide counts. - Validating assays with biological samples for accuracy. The study involved preparing plasma samples and categorizing assays into P100, P800, and P2000 types. Results showcased Stellar MS's exceptional performance, detecting 1913 out of 1960 SIL peptides and ensuring high reproducibility and robustness. This innovation has significant potential for advancing biomarker discovery and clinical diagnostics. #BiomarkerDiscovery #StellarMS #Proteomics #ThermoScientific #MassSpectrometry Learn more » https://lnkd.in/drVZXSr8

Today Clene Nanomedicine, Inc. presented new data from the HEALEY-ALS Platform trial that supports #CNMAu8 efficacy at the 2024 #ENCALS meeting in Stockholm, Sweden. The data shows the drug’s performance during the randomized, double-blind portion of the trial through the long-term, open-label extension. Key highlights of the presentation include long-term survival benefit with CNM-Au8 30 mg treatment compared to PRO-ACT propensity-matched controls, and continued decline in plasma neurofilament light biomarker levels with CNM-Au8 treatment. See more details here: https://bit.ly/3VsqpZ2 #EndALS #ENCALS

lf you are attending #AACR2024, we invite you to come to our oral presentation, where we'll discuss development of Claudin18.2 IHC 14G11 pharmDx as a clinical trial assay for the clinical development of anti-Claudin 18.2 monoclonal antibody Osemitamab (TST001) in gastric and gastroesophageal junction adenocarcinoma.

🚨 Mark your calendar for October 17th! 🚨 We’re excited to invite you to a groundbreaking webinar where the Eurofins Discovery Biophysics team and Eurofins CALIXAR unite their expertise to present: "Unprecedented Fragment-Based Screening Using Spectral Shift for GPCRs"! Join our experts—Vanessa Porkolab, Maud Sigoillot, and Alexis Moreno—as they reveal cutting-edge methods for producing and characterizing challenging recombinant proteins like GPCRs, and explore the vital role biophysics plays in hit finding and confirmation. 🔬 Unlock new possibilities for your research with insights on: - Fragment-Based Screening (FBS): See how fragment-based drug design uncovers novel binding sites on membrane proteins. Using Spectral Shift technology, our team identified antagonist hit fragments for the human adenosine A2A receptor. - Accelerating Drug Discovery: Discover how Eurofins CALIXAR’s GPCR production expertise combined with biophysics technologies can speed up your drug discovery pipeline. - GPCRs & Spectral Shift: Learn how FBS with Spectral Shift technology opens new avenues for finding hidden binding sites on membrane proteins. Don't miss this opportunity to gain cutting-edge insights from the forefront of GPCR drug discovery! Register today and secure your spot: https://lnkd.in/gFN6CDKA #DrugDiscovery #GPCR #FragmentBasedScreening #Biophysics #SpectralShift #PharmaInnovation #Webinar

Flow cytometry plays a pivotal role in clinical development by enabling detailed, single-cell analysis to assess immune responses and therapeutic efficacy. In our latest Q&A, Medpace scientists explain how this powerful tool can enhance trials by analyzing thousands of cells simultaneously, supporting CAR-T therapy, and assessing biologic therapies.   Download the article to learn more about the role of flow cytometry in clinical trial #biomarkers: https://lnkd.in/gqwATyH8

Advanced Proteins Innovation Showcase – Membrane Proteins Discover the future of engineered conformational proteins at AAI! Bioactive proteins not only mimic but also interact like native conformations.   The CMP™ nanoparticle technology platform produces native conformational membrane proteins by using the self-assembling and then budding functions of the viral structural proteins. A proprietary design is used to select viral backbones with structural proteins resulting in high quality membrane protein presenting nanoparticles. These membrane proteins can be used as an:   immunogen: generates antibodies against complex membrane protein for translational research and therapeutic discovery   lipid-bilayer-based antigen: can screen for binders and analyze affinities or perform biophysical and structural investigation of complex membrane proteins   Visit Conigen at AAI booth #337 to review our data on membrane proteins. Dive into the science that's empowering translational research and drug discovery.  https://lnkd.in/eZ2CXKZD #AAI2024 #Immunology #InnovateWithConigen #AdvancedProteins

📰 In the Summer 2024 edition of Drug Discovery World, Diana Spencer examines the most recent advancements in high-throughput screening technologies for drug discovery and their potential to expedite therapeutic development: https://ow.ly/cnIH50Stkl3. During her discussion with Shan D., Vice President of Strategy and Innovation at Molecular Devices, Shan emphasizes the significance of automated cell culture and how our CellXpress.ai Automated Cell Culture System offers a solution for researchers that incorporates machine learning to enhance processes like media exchange, plating, passaging, organoid monitoring, endpoint assays, and complex image analysis—ultimately increasing both productivity and reproducibility in drug screening. #3dbiology #3dcellculture #organoids #drugdiscovery #drugscreening #drugdevelopment #diseasemodeling #labautomation #ai #machinelearning #deeplearning #highcontentimaging #highcontentscreening #scienceandtechnology #pharma #geneeditting #cellculture #pdo #imageanalysis #IntheNews