Alentis Therapeutics’ Post

Check out the great work on CLDN1 and organ fibrosis presented by Prof. Pierre-Louis Tharaux's team and Prof. Wim Wuyts's team at the ERA and ATS conferences. Their collaborative research is paving the way for future treatment strategies. #FibrosisResearch #Innovation #ERA2024 #ATS2024"

Sacubitril-Valsartan in #CKD Stage-5 patients on #dialysis "This systematic review suggests that sacubitril-valsartan benefits patients with ESKD with HFrEF and HFmrEF by improving LVEF without increasing the risk of hyperkalemia, hypotension, or angioedema compared to standard care." #nephrology #nephrocardiology

Interesting findings about how #OCTA could be used to detect changes in the retinal vasculature during and between migraine attacks. Results suggest that changes in retinal perfusion could be part of the pathophysiology of #migraine.  

As Lead Editor of the newly released Research topic on BPPV in Frontiers in Neurology, I am thrilled to witness a paradigm shift in our comprehension of BPPV. Alongside esteemed experts including Prof. Francisco Zuma E Maia Prof. Eduardo Martin Sanz, Prof. Bernardo Faria Ramos, and Dr. Shivam Sharma, our editorial delves into a transformative era in diagnostics, simulations, treatment modalities, and molecular insights, illuminating the complexities of BPPV, a prevalent cause of dizziness. https://lnkd.in/g7jNgjKh #bppv, #neurotology, #maneuvers, #vertigo Frontiers

🌐 Nuances of Gamma Knife Radiosurgery in Vestibular Schwannoma Treatment As neuroradiologists, we're often on the lookout for indicators of treatment success. In the realm of Gamma Knife radiosurgery for vestibular schwannoma, a common phenomenon (up to 41% of cases) challenges our conventional understanding: the temporary enlargement of the tumor post-treatment. 🔬 Why is this significant? This enlargement isn't a setback. Rather, it's a biological response to radiation, a critical factor that can complicate the interpretation of MR images in the early stages after treatment (up to 2 years). 🔎 Clinical Insights from Microsurgical Resection: When tumors that have enlarged post-radiosurgery are resected, they exhibit: Hyalinized thrombosis Thickening of the vascular wall Vascular obstruction Granulomatous changes #GammaKnifeRadiosurgery #Neurosurgery #neuroradiology #mri #VestibularSchwannoma

Intense basics of neurology Session 3: 11/06/2024 Topics: 1. Neuron 2. Neuroglia 3. Brain and spinal cord tumors 4. Nerve fibre composition and classification 6. Nerve fibre properties and nerve injuries Timing: 8:20pm-9:35pm

Published in 𝘚𝘵𝘳𝘰𝘬𝘦: 𝘝𝘢𝘴𝘤𝘶𝘭𝘢𝘳 𝘢𝘯𝘥 𝘐𝘯𝘵𝘦𝘳𝘷𝘦𝘯𝘵𝘪𝘰𝘯𝘢𝘭 𝘕𝘦𝘶𝘳𝘰𝘭𝘰𝘨𝘺, an analysis of the largest series of patients with “benign” perimesencephalic subarachnoid hemorrhage suggests that those without aneurysm or hydrocephalus can have shorter hospital stays and less-strict monitoring. Senior author, Gabor Toth, MD, details the findings. #CleClinicNeuro

In the world of #spinesurgery, understanding every possible complication is crucial. Today, let's discuss Spinal Cord Reperfusion Injury (SCRI), or White Cord Syndrome – a rare but serious concern in anterior or posterior decompressive spine surgeries, particularly in the cervical and thoracic regions. SCRI occurs when blood flow returns to a previously ischemic area of the spinal cord. This reperfusion triggers an inflammatory cascade, releasing damaging free radicals that disrupt the phospholipid membranes of neurons and the blood-spinal cord barrier. Key players like TNF-alpha contribute to oxidative stress post-reperfusion. Clinically, we often observe a decrease in TcMEPs or SSEPs (though in one reported case complications only emerged 24 hours postoperatively). Further research is imperative to deepen our understanding of this phenomenon, especially since our standard practice of increasing blood pressure in response to a significant change in SSEPs and TcMEPs might inadvertently worsen the condition. If SCRI is indeed caused by reperfusion, then elevating blood pressure could potentially intensify the reperfusion, thereby exacerbating the injury. This highlights the need for a careful reassessment of our current treatment approaches in these cases. #IONM #neurophysiology #neuroscience

#Optilume was developed in response to the dissatisfaction of patients undergoing endoscopic procedures for urethral stricture, as well as the dissatisfaction of doctors still relying on endoscopic interventions with high failure rates. Its technology combines urethral dilation and the delivery of medication directly into the urethral canal. The rapid absorption of the highly lipophilic drug, Paclitaxel, limits hyperactive cell proliferation and the generation of fibrotic scar tissue responsible for recurrence of the stricture, continuing to act for 28 days post-procedure. For more information 👉🏻 https://lnkd.in/dBbxXCgE #ACTAgroup #innovation #urology #medicine #scientificinnovation #fordignityforlife #laborie Laborie

Quick update on my Honors Thesis on Colocalization of Necroptosis Markers in Diabetic Mice Schwann Cells. Data collection is largely finished, pointing out to significance between necroptosis rates of healthy and diabetic mice. This is exciting news, as it reveals more about the development mechanism of Diabetic Bladder Dysfunction, that currently doesn't have a cure. Inhibition of proteins that play important roles during necroptosis (such as MLKL or RIP Kinases) could prove to be a useful treatment. After another 5 months of further data collection and writing, I will present my findings at 2024 Duke Multidisciplinary Benign Urology Research Symposium and Honors Poster Symposium. Looking forward to sharing the details of my research with you late April!