AnaSpec’s Post

Given the current excitement in peptides, in particular cyclic peptides, as therapeutic modalities Charnwood Discovery are happy to be sponsoring the SCI Fine Chemicals Group New Modalities: Innovations in Peptides meeting. Please come and chat to James Krupa and myself on how we support the synthesis and biological evaluation of peptides. You can find more information below especially how we supported a H2L project synthesising over 200 cyclic peptides consisting of bespoke amino acids (eg peptoids) based on our PurePep Chorus by Gyros Protein Technologies 👇 https://lnkd.in/eBAX8-_H #SCI_NewModalities #peptides #drugdiscovery

Exciting news! Explore BioPure Peptides' extensive product range with ease. 🧬 Discover high-purity peptides tailored to your research needs, all with detailed information and streamlined navigation. Stay tuned and be the first to explore our selection! #BioPurePeptides #ExploreOurRange #ResearchPeptides #PeptideCatalog #PurePeptides #LabResearch #BiotechResearch Check out our full range at www.biopurepeptides.com!

Strategic incorporation of a novel proline-like moiety at the P2 position in dipeptidyl compounds led to identification of highly selective and potent cathepsin K inhibitors while modifying the tert-butyl-pyrazole to a trifluoromethylpyrazole at the P3 position resulted in the re-establed the activity against CatK. The chosen 4-methylproline scaffold resembles in 95 % the 3D structure of leucine while keeping the molecular mass constant and reducing the calculated ClogP from 2.3 to 1.6, played a significant role in improving the solubility. The study drives home the message that introducing non-natural amino acids can be an exciting option to achieve selectivity over undesired targets. https://lnkd.in/g5waS7CG

Our preprint on “Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides” is now available on ChemRxiv 🧪🧫 https://lnkd.in/ea45P6kV We incorporated various non-canonical amino acids and backbone modifications into Microcin J25, highlighting the remarkable versatility of the two maturation enzymes McjB and McjC. Our method provides rapid access to chemically modified lasso peptides that could be used to investigate structure-activity relationships, epitope grafting, and improvement of therapeutic properties. w/ Kevin Schiefelbein, Jakob Lang, Matthias Schuster, Claire Grigglestone, Robin STRIGA, Laurent Bigler, Meredith C Schuman, Oliver Zerbe, Yanyan Li 🙏 #peptides #RiPPs #SPPS #flowchemistry

For all your research needs, trust BioPure Peptides! 🧬 We offer high-purity peptides that meet the strictest quality standards, ensuring you have reliable products for your scientific projects. No matter your research focus, we've got you covered with top-tier peptides made right here in the USA. #BioPurePeptides #ResearchPeptides #ForYourResearchNeeds #PurePeptides #LabResearch #PeptideScience #USAMade #BiotechResearch Explore our full range at www.biopurepeptides.com!

Our newest application of ion mobility mass spectrometry in structure elucidation of lasso peptides.

Overcoming challenges like aggregation in peptide synthesis requires innovative strategies. One such method involves the use of Fmoc-pseudoproline dipeptides, disrupting hydrogen bonds and streamlining the synthesis process. This approach has revolutionized peptide synthesis, creating longer and more complex peptides with remarkable efficiency. https://lnkd.in/eybiv3HY

Check out our Customer Highlight featuring Nimble Therapeutics's VP of Therapeutic Discovery, Lauren Goodrich-Berto: "Rapid access to diverse chemical space is critical for identifying peptide hits and transforming them into clinical candidates. One of the most successful strategies in peptide discovery is the incorporation of noncanonical amino acids. However, access to noncanonical amino acids has been extremely costly, even with significantly restricted chemical space. This is especially true for building blocks in the D-configuration. Aralez Bio has unlocked a vast toolbox of noncanonical amino acids, enhancing Nimble’s platform and allowing us to tune peptides in ways that were not previously feasible. Our scientists are excited to access new amino acid space for the discovery and optimization of peptide ligands. The icing on the cake is that the enzymatic process is significantly greener than “traditional” amino acid synthesis. We look forward to seeing what additional noncanonical amino acids Aralez Bio can unlock in the future." To see what's available now & coming in the future, email us at info@aralezbio.com #noncanonical #ncAA #aralezbio #customerhighlight #peptide #greenchemistry #sustainability

Preservation of protein integrity by protecting against proteases is critical in life science research and clinical settings. To maintain the integrity of proteins, protease and phosphatase inhibitors are essential to block the proteases, the enzymes that would otherwise degrade proteins of interest. Optimize your protein production yield with Boston BioProducts’ new Protease and Phosphatase Inhibitors product line: https://lnkd.in/d_AA7KUg