André de Vries’ Post

Let’s talk about macrocyclization! Drawing inspiration from nature's complexity, macrocyclization enhances bioactive small molecules by improving potency, target selectivity, and other crucial biological and physiochemical properties.   Discover more about their transformative impact on pharmacological potential via this short article on our website. (Link in comments) Please contact us if you want to discuss a project that might benefit from the Symeres macrocyclization capabilities.   #Symeres #CRO #DrugDiscovery #Macrocyclization #Innovation #BioTech #Pharma #Research

Touchlight’s dbDNA™ is a linear, double stranded, covalently closed DNA vector which is produced through an enzymatic manufacturing process. The cell-free process avoids selective pressure often associated with plasmid instability which produces truncations and malformations of DNA. Learn how we can address your DNA challenges: https://lnkd.in/e8meAqY #biotechnology #pharma #biotech #genetherapy #dbDNA

Product of the week : (Z)-6-Hydroxyhex-3-en-1-yl 4-methylbenzenesulfonate 3-Hexene-1,6-diol, mono(4-methylbenzenesulfonate), (Z)- (9CI) CAS No.： 72530-34-8 Approach us for your Discovery Solutions!!! Transform your R&D journey with our cutting-edge discovery solutions. Whether you're in biotech, pharmaceuticals, or academia, our expertise accelerates innovation. Reach out today and let's pioneer the future together. #DiscoverySolutions  #Innovation #ResearchAndDevelopment #CRO #DrugDiscovery  #Research #Development  #CRAMS #linkedin #PROTAC #BuildingBlocks  #linkedincommunity  #Ligands #Linkers  #protein  #ligand #Medchem  #MedicinalChemistry #PROTACs #Innovation  #Targeted  #Protein  #drug #discovery #combi #dmf #fte #blocks  #Novel  #Approach #Crosslinker #Portfolio #proteolysis #Ligase #synthetic #Linker #smallmolecule #compounds  #CDMO #CRDMO  #CMO #chemtech  #outsourcing  #chemicalindustry #drugdiscovery #medchem  #express  #medicinalchemistry  #organic  #chemistry #ligands  #scaffold  #medchemexpress #marketresearch #research

Beginning the year updating the Ubiquigent 2024 Research Tools catalogue 📣 Did you know we sell high-quality reagents to support #ubiquitin-system research? We have 100s of validated reagents including DUBs and their substrates, Ubiquitin substrates, chains & binding proteins, E1 / E2 #enzymes & E3 #ligases, #proteosome, #kinases and much more.  Useful to discover the next clinical DUB inhibitor/modulator or in #TPD and developing #PROTAC® Importantly, and what provides our users confidence, we utilise many of these products in our platform to support clients and partners or drive our internal R&D goals. You can check out the list attached or click here https://lnkd.in/gcyyVxHe to find out more. Any questions just ask. #deubiquitinases #DrugDiscovery #DrugDevelopment #DUB #DUBTAC #E3Ligase #TargetedProteinDegradation #research #pharma #biotech

CellRev have been working with C2C12 cells for several years now in an effort to demonstrate true continuous processing of adherent cells. Read our case study to understand how we are facilitating the transition to continuous processing. https://hubs.ly/Q02c-y-H0 We have now shown compatibility with several cell lines including VERO Cells, iPSCs, and Fibroblasts. Get in touch on enquiry@cellrev.co.uk to discuss your requirements #cellmanufacturing #celltherapy #biomanufacturing #cellculture #bioprocessing #processautomation #biosciences #biotechnology #biopharma #pharma #biotech #innovation #biotechnology #bioengineering

Exciting research on a novel biocatalytic process! ⚗️ Our SpinChem rotating bed reactor was used for reactions in the process of synthesizing Nemtabrutinib. By immobilizing the transaminase enzyme, stability was improved allowing for extended operation in organic solvents. The final streamlined and robust process enables simplified, direct isolation of the product as a crystalline salt. Exactly such operationally straightforward, and productive processes will give rise to the effective use of biocatalysis to transform chemical production!🌱 Find more about this publication here: https://lnkd.in/dJHaeVH7 The authors to this study are: Christopher Prier, Karla Camacho Soto, Jacob Forstater, Nadine Kuhl , Jeffrey Kuethe, Wai Ling Cheung-Lee, Mike Di Maso, Claire M. Eberle, Shane Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin Maloney, Amanda Makarewicz, Jon McMullen, Jeffrey Moore, Grant Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David Thaisrivongs, Deeptak Verma, Adeya Wyatt, and Daniel Zewge. #biocatalysis #enzymeimmobilization #greensolvent #enzymeengineering #transamination #pharmaceuticals #rbr #spinchem

🔬 Looking to advance your research with high-quality Discovery Building Blocks, PROTAC Ligands, and Linkers? Look no further! Our catalog features a diverse range of compounds designed to accelerate your discoveries in drug development, chemical biology, and beyond. Why choose us? ✅ Premium Quality ✅ Competitive Pricing ✅ On-Time Delivery Together, let's unlock the potential of your discoveries! Reach us : Email: info@eversynlaboratories.com Or Mobile: +91 88850 22850 #DrugDiscovery  #Research  #Development  #CRO  #CRAMS  #BuildingBlocks  #PROTAC  #Ligands  #Linkers  #protein  #ligand  #Medchem  #MedicinalChemistry  #PROTACs  #Innovation  #Targeted  #Protein  #drug  #discovery  #combi  #blocks  #Novel  #Approach  #Crosslinker  #Portfolio  #Ligase  #synthetic  #Linker  #smallmolecule  #compounds #scaffold #fragment #drugmolecules #DrugDesign #Privileged #BuildingBlocks #medicine #healthcare #pharmaceuticals #medchem #researching #pharma#active #agents #screening #Advanced #Chemical #BuildingBlocks #Novelscaffolds

#WRIB is in full swing and Steve Lowes, Richard Snyder, Sara Brady, Rickerson Felix, MBA, and the rest of the Q2 Team are excited to meet with you and talk about your upcoming plans and/or help you overcome scientific, quality, deliverables, or other challenges. Want to set up a time to meet here at WRIB, or if you’re not attending and want to chat, just click here: https://lnkd.in/eRPJS6Uz #drugmetabolism #pharmacokinetics #lifescience #invitro #biotransformation #dmpk #pharma #biotech #research #drugdevelopment #bioanalysis #bioanalytical #immunoassay #lcmsms #lcms #hrms #pharma #adme #oligonucleotides #monoclonalantibodies #rnabasedtherapeutics

The ideal biologic is abiological. The potential of existing biological medicines hasn't been realized because we've been limited by the boundaries of nature - until now. Abiologics is creating Synteins de novo using a broad set of artificial building blocks, far beyond the 20 naturally occurring amino acids that form the basis of today’s biologic medicines. These include biologics built with D-amino acids, chemically identical mirror images of standard amino acids. By surpassing the limitations of traditional drug discovery tools, Abiologics is the first to discover, prototype and scale-up polymers composed solely of artificial building blocks. See how we're creating supranatural biologics for maximum patient benefit: https://bit.ly/3W8GSSo #biotechnology #innovation #drugdevelopment #FlagshipFounded

👍 A new study has successfully identified key missing enzymes in #paclitaxel’s biosynthetic pathway – potentially laying the foundation for large scale production of this leading #CancerDrug. > Because of its complex molecular structure, paclitaxel can only be made semi-synthetically at present, which means that production is limited by the availability of slow-growing natural materials. (Learn more in LGC Mikromol™'s #PharmaRoots article: https://okt.to/E3tvm0) >The global market for paclitaxel products is expected to be worth $20 billion by 2025, but the lack of a fully synthetic route means that manufacturers cannot fully meet growing demand. 🔬 LGC Standards meanwhile provides a range of high quality research chemicals and reference materials to support your laboratory’s paclitaxel analysis: https://okt.to/pPxGtj #pharma #PharmaceuticalAnalysis