Applied BioMath’s Post

Learn how QSP models can assist in accelerating the reuse of immuno-oncology drugs, such as T-cell engagers and CAR-T therapies, in the autoimmune space in our latest blog written by Saheli Sarkar, PhD, Senior Principal Scientist, and Marc Presler, PhD, Associate Director of Biology at Applied BioMath. Read the blog at: https://lnkd.in/eT8TtQgF #immunooncology #autoimmunediseases #qsp #mathematicalmodeling

Let's leverage the investment made in the IO space to bring new therapies to those suffering from autoimmune diseases with the appropriate urgency. Read the blog here! https://lnkd.in/eKmvUAtt

On this day in science Richard Axel was born. Humans can distinguish more than 10,000 scents. Odors stir human memory and responses. But the basic mechanism was mysterious when Richard Axel and UW alumna Linda Buck set out to understand what lay behind the sense of smell. In elegant experiments, they identified the genes that control odor receptors For their work they shared the 2004 Nobel Prize in Physiology or Medicine "for their discoveries of odorant receptors and the organization of the olfactory system. #science #sciencecommunication #nobelprize #biochemistry #pharma #N #scienceandtechnology #biotherapeutics #olfactory

Our discovery solutions: the drug discovery engine of choice, for even the most challenging targets! We know that in early drug discovery, every cog matters. If one cog is missing, you might not find any compounds, let alone the best hit ⚙️ Having the RIGHT protein in the beginning is crucial. We can help you identify the right protein, alongside the right discovery technologies, cutting-edge structural biology, tailor-made assay development, wide ranges of screening library access options, combined with the full spectrum of biophysical mode-of-action methodologies. Welcome to our Discovery Solutions, we’ve been expecting you! Let’s work together to find the best hit compounds, and make your drug discovery program a success! 🎯 https://lnkd.in/ev33Ufs6 #DrugDiscovery #EarlyDrugDiscovery #DrugDevelopment #DrugDesign #StructuralBiology #AssayDevelopment #ProteinScience

#Journal_Club Session 12 The Journal Club will be held on Tuesday July 12, 2022, from 7:00 PM to 8:00 PM. in this session we will discuss the article titled: "Highly accurate protein structure prediction with AlphaFold" Lecturer: Dr. Elaheh Kashani-Amin (https://lnkd.in/gH_tXDf7) PhD, Molecular Medicine, Protein Molecular Modeling and Computer-aided Drug Design The sessions are free of charge. Skype group:  Tuesdays with Journal Club Skype address: https://lnkd.in/enYE9-y3 Telegram: @molecular_modeling Instagram: @go_molecular_modeling #drugdesign #computationaldesign #molecularmodeling #computationalbiology #Protein #nucleicacid #alphafold #3Dstructure #molecular_docking #molecular_Dynamics_simulation #MD_simulation #homology_modeling #CADD #pharmacophore

There has been remarkable progress made in the use of patient tissue derived primary #organoids for the in-vitro modeling of Cystic Fibrosis (CF) pathogenesis and testing of therapies targeting mutant CFTR. Induced Pluripotent Stem Cells (iPSCs) can be differentiated into epithelial organoids that recapitulate the relevant context for CFTR and enable testing of therapies targeting #CysticFibrosis (CF)-causing mutant proteins. In this article, Sunny Xia et al. describes a #highthroughput, fluorescence-based assay of CFTR channel activity in iPSC-derived intestinal organoids and demonstrates how this method can be adapted to study other apical membrane proteins. Additionally, they discuss how the FLIPR® membrane potential sensitive dye can be used to measure function of apical CFTR and ENaC channels as well as the electrogenic amino acid transporter, SLC6A14. Hence, multiple, disease-relevant, electrogenic #membrane proteins can be interrogated in the same patient-derived tissue. These innovations have expanded the potential application of CF organoid models to include therapy testing for multiple therapeutic targets. Read the article ➡️ https://bit.ly/3TWzPLB

#CellImmortalization is a process that allows cells to bypass their natural limit on replication, enabling them to proliferate indefinitely in culture. This remarkable ability holds tremendous potential for a wide range of applications, from basic research to drug discovery and regenerative medicine. Here's our platform introduction: https://lnkd.in/ejWjwQpQ #CellImmortalizationService #TCellAndMacrophageImmortalization Service #BCellImmortalizationService #KMDBioscience

A potency assay aimed at studying direct interactions between mesenchymal stromal cells (MSCs) and macrophages under proinflammatory conditions- relevant for regenerative medicine: https://lnkd.in/ej2Ymj_v The protocol uses naïve macrophages derived from monocytes to maintain genetic consistency. It requires a plate reader and flow cytometer capable of detecting six fluorophores for quantitative assessment, allowing evaluation of macrophage phenotype and secretome changes to understand mesenchymal stromal cells' immunomodulatory effects more effectively. Work by Hazel Stevens, Angela Jimenez, Bryan Wang , Ye Li, Shivaram Selvam, and Annie Bowles-Welch, PhD at MC3M (Marcus Center for Cell Characterization and Manufacturing), Georgia Institute of Technology Reviewed by Vivien Coulson-Thomas Explore publishing with Bio-protocol at https://lnkd.in/gR3QGYz6! #openaccess #reproducibility #lifesciences #research

Is spatial biology right for you? Many drug development programs, particularly in the immuno-oncology space, can benefit from the power of spatial techniques. Spatial technology is complex and must be used in the right way at the right stage to truly derive its value. REALM Pharma Services brings together the expertise you need to determine exactly what you need for your unique study. #spatialbiology #immunooncology #REALMPharmaServices

I'm excited to share our latest work, published in Small Science (WILEY), which reports de novo designed transmembrane ion channels using α-Peptide-oligourea Foldamers. The crystal structure reveals its channel-like self-assembly in solution. These tunable α-Peptide-oligoureas can be used as bioactive materials with defined structures and functions. Thanks to my PIs and collaborators for their support and guidance. Please access the full article here: https://lnkd.in/ghBjg8Gg #newpublication #postdocwork #researcharticle #NUS