AQEMIA’s Post

Abstract submission deadline for RICT 2024 is May 14! Submit your abstracts for poster presentation on the following topics: - Chemistry in Living Systems and Chemical Biology - Induced Proximity Including Degraders - Next Generation Cancer Therapeutics - New Modalities for Drug Discovery - Enabling Technologies - Recent Trends in Neurodegenerative Diseases Drug Development - First Disclosures of Clinical Candidates and Cases Studies - Breakthroughs in Deep Learning, CryoEM and their Impact on Drug Discovery A limited number of grants will be funded by the SCT and Corporate Sponsors to support the participation of young academic scientists presenting a poster at the conference. Find out more on www.rict2024.org/grants Register and submit your abstract on https://lnkd.in/emdk7JYN #MedChem #MedicinalChemistry #DrugDiscovery

Folks, xBiologix is heading to #BIO2024 to connect solid phase tumor profiling with translational research & preclinical drug development. Join us in San Diego and learn how a simplified single staining step & multiplexed immunofluorescence makes profiling the required number of biomarkers available to virtually any research scientist or pathologist. #spatialbiology #multiplexIF

It is indeed an honour to present our poster on the 15th Wädenswil Day of Life Sciences: 6th June 2024 at the symposium “Competencies in Drug Discovery” in Zurich, titled: “Strategic in silico pipeline for PROTAC screening: validation with CRBN-RN6-BRD4”.  We showcase our integrated computational & bioinformatics pipeline-guided evaluation of therapeutic targets and design of PROTAC molecules with emphasis on linker chemistry. PROTACs are the hottest therapeutic modalities to tackle undruggable targets where SMs fail to show the expected therapeutic outcome. BRD4 is a classic example of a potential anti-cancer target; PROTAC-mediated targeting of BRD4 has proven beneficial over SMs. Our pipeline aids in the identification of an optimal preclinical model for efficacy and safety/tox study. We provide a way forward in predicting the impact of deubiquitinating to estimate the therapeutic area-specific efficacy of the designed PROTACs.    We are excited to meet you at the poster session!  To download the poster,click: https://lnkd.in/gAEuSc5j     #ZHAW #Insilico #Bioinformatics #Cancer #PROTAC #DrugDiscovery #Integratedpipeline #TCGLifeSciences #DataScience #BRD4 #DUB #Efficacy #Toxicity    Sohini Basu, Snigdha Patel, Nivedita Dharwar, Anupama Goyal, Sonali Das, Joaquim Figueiredo

🔬🌱 Exciting Update from the National Conference on Biotechnology! 🔬🌱 I'm thrilled to share that I recently had the privilege to participate in the National Conference on Recent Trends in Biotechnology, organized by the esteemed Society for Progressive Learning and Research. The event was an incredible platform to delve into the latest advancements shaping the future of biotechnology. My contribution centered around the intersection of Artificial Intelligence and its potential in revolutionizing treatment against Blood Cancer. Titled "Current Trends in Artificial Intelligence versus Treatment against Blood Cancer," the presentation explored how AI-powered innovations are reshaping the landscape of medical research and treatment methodologies. In a rapidly evolving field like biotechnology, collaboration and knowledge-sharing are key to driving progress. It was inspiring to engage with fellow researchers, industry experts, and thought leaders at the conference, exchanging insights and ideas that have the potential to drive meaningful change in healthcare. I'm immensely grateful for the opportunity to be part of such a dynamic and forward-thinking event. Special thanks to the Society for Progressive Learning and Research for organizing this invaluable gathering. Looking forward to continuing the dialogue and contributing further to the advancement of biotechnology. #Biotechnology #ArtificialIntelligence #HealthcareInnovation #CancerResearch #ConferenceHighlights #SPRLR2024

🌟 Friday Read: Accelerating Drug Development with Spatial Biology 👉https://bit.ly/4aro6Lo Presage Biosciences, Inc.'s CIVO® platform, combined with GeoMx and CosMx technologies, effectively tracks anti-neoplastic and immune-modulating activity in the intact tumor microenvironment. This innovative approach is speeding up drug development and paving the way for more successful clinical trials.🔬 #SpatialBiology #DrugDevelopment #FridayRead This post may include information regarding CosMx™ SMI products for RNA detection, which products are not available in the Federal Republic of Germany, as further described here - https://lnkd.in/gUXh88Pr.

We present here an insightful informatics based pipeline for prediction of PROTAC therapeutic modality outcome.

Click, click, boom—🧪 in a flash, 150 novel molecules materialize, potentially reshaping drug discovery as we know it. This isn't science fiction, it's hard chemistry simplified thanks to the brilliant minds at Cold Spring Harbor Laboratory. Imagine this: new antibiotics and cancer therapies sprouting in days, not months. That's the game-changing promise of the Accelerated SuFEx Click Chemistry (ASCC) developed by Professor John Moses and his team. 🚀 Faster, efficient molecular link-ups are catapulting the drug development process into hyperdrive. The ASCC method isn't just quick; it's meticulous and bountiful. More than a mere handful of new compounds, Moses' team crafted over 150, each with the potential to tackle the fiercest of cancers and meanest, drug-resistant bacteria. And they're not stopping at creation—they're diving headlong into testing. 🧫 Among this molecular treasure trove, derivatives of the heavy-hitting anti-cancer agent combretastatin A4 stand out, displaying lethal efficiency against cancer cells too stubborn for conventional chemo. Meanwhile, dapsone-like antibiotics are showing up bacteria that thought they'd grown invincible. The impact? It's monumental. ASCC is not just speeding up synthesis—it's providing a wellspring of hope for those battling cancer and life-threatening infections. 🎯 The mission now is fine-tuning these discoveries into drugs that can make their way to a pharmacy near you. With ASCC, what used to stretch over seasons can now be done almost overnight. #DrugDiscovery #Innovation #Chemistry breakthroughs

“How recent technological advancements such as spatial biology, single cell genomics, and complex in vitro models are revolutionizing the way drugs are developed." Upcoming Keynote Lecture David Walt, PhD, Scientific Founder of Illumina and Professor of Pathology at @Harvard Medical School.    I've had the pleasure to visit with David Walt in Boston and welcome him Toulouse when I was in the field of Electronic Noses (Pattern Recognition and Chemical sensors). Our paths have not crossed directly again. I recently realized we (Primetech Corporation) distributes ground breaking Spatial Biology Solutions from Vizgen in Japan where he is one of the founders. His Keynote Lecture is in Drug Discovery Day on April 3rd with Endpoints News. In the meantime, I recommend you check out last year’s Drug Discovery Day which I missed until yesterday. Fortunately, available on demand and still very relevant today. "The heat is on to find new ways to advance preclinical drug research" with David Grainger, Centessa Pharmaceuticals; Lorna Ewart, Emulate, Inc.; John Connolly, Parker Institute for Cancer Immunotherapy; John Carroll, Endpoints News. #preclinical #drugdiscovery #drugdevelopment #spatialbiology #singlecellgenomics #nams (by FDA)

A great case study in both biological mechanisms and potential therapies for neuroinflammation and neurodegeneration. I was truly impressed with the research by Superior Medical Experts team and the therapeutic targets of BioScience Pharma (https://lnkd.in/g-3DGTrS) in two 'tandem' narrative reviews surrounding (1) Leukotrienes, microglia, and the pathways of persistent neuroinflammation, and (2) The pre- and clinical evidence on FLAP Inhibitors in neurodegenerative diseases. This also may be one of my favorite uses of the "Embedding" feature of the visuals from Nested Knowledge, Inc.-- see the case study for more! https://lnkd.in/gQe9VAKV

I am just as excited as Julian about the potential of the field of TPD and induced proximity for treating disease. Please register for the webinar linked below to learn more about how SPR can be used to help discover and characterize these modalities.