Arun D.’s Post

Hello, Dear Connections, As someone interested in the biomedical engineering field, I am excited to share some advancements in nanotechnology that are transforming drug delivery systems. The convergence of nanotechnology and medicine is opening up new frontiers for more effective, targeted, and personalized treatments. Here’s how: 🔬 Precision Targeting Nanotechnology enables the development of drug delivery systems that can precisely target diseased cells, minimizing the impact on healthy tissues. This precision reduces side effects and increases the efficacy of treatments, particularly in cancer therapy. Nanoparticles can be engineered to recognize and bind to specific cell receptors, ensuring that the medication reaches its intended destination. 💡 Enhanced Drug Solubility and Bioavailability Many drugs suffer from poor solubility and bioavailability, limiting their effectiveness. Nanotechnology can enhance the solubility of drugs, allowing for better absorption and improved therapeutic outcomes. Nanocarriers, such as liposomes and polymeric nanoparticles, help in delivering hydrophobic drugs in a more soluble form. ⏳ Controlled and Sustained Release Nanotechnology allows for the design of drug delivery systems that provide controlled and sustained release of medication. This means that drugs can be released at a consistent rate over a prolonged period, reducing the need for frequent dosing and improving patient compliance. The controlled release also ensures a steady therapeutic effect, enhancing the overall treatment process. 🌐 Crossing Biological Barriers One of the significant challenges in drug delivery is crossing biological barriers, such as the blood-brain barrier. Nanoparticles have shown promise in overcoming these barriers, enabling the delivery of drugs to previously inaccessible areas of the body. This advancement opens up new possibilities for treating neurological disorders and brain cancers. 🔍 Future Prospects The future of nanotechnology in drug delivery is incredibly promising. Research is ongoing to develop smart nanoparticles that can respond to environmental stimuli, such as pH or temperature changes, for on-demand drug release. Additionally, integrating nanotechnology with other cutting-edge fields like gene therapy and immunotherapy holds the potential for creating highly personalized treatment regimens. Thank you for reading, and let’s keep pushing the boundaries of biomedical engineering! #BiomedicalEngineering #Nanotechnology #DrugDelivery #HealthcareInnovation #TargetedTherapy #ControlledRelease #FutureOfMedicine

Nanomaterial with potential to tackle multiple global challenges could be developed without risk to human health. A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests. The study is published in the journal Nature Nanotechnology. Carefully controlled inhalation of a specific type of graphene—the world's thinnest, super strong and super flexible material—has no short-term adverse effects on lung or cardiovascular function, the study shows. The first controlled exposure clinical trial in people was carried out using thin, ultra-pure graphene oxide—a water-compatible form of the material. Researchers from the The University of Edinburgh and The University of Manchester recruited 14 volunteers to take part in the study under carefully controlled exposure and clinical monitoring conditions. The volunteers breathed the material through a face mask for two hours while cycling in a purpose-designed mobile exposure chamber brought to Edinburgh from the National Public Health Institute in the Netherlands. Effects on lung function, blood pressure, blood clotting and inflammation in the blood were measured—before the exposure and at two-hour intervals. A few weeks later, the volunteers were asked to return to the clinic for repeated controlled exposures to a different size of graphene oxide, or clean air for comparison. There were no adverse effects on lung function, blood pressure or the majority of other biological parameters tested. Researchers noticed a slight suggestion that inhalation of the material could influence the way the blood clots, but they stress that this effect was very small. Dr. Mark R. Miller of the The University of Edinburgh's Centre for Cardiovascular Science, said, "Nanomaterials such as graphene hold such great promise, but we must ensure they are manufactured in a way that is safe before they can be used more widely in our lives. ...Professor Kostas Kostarelos, of the The University of Manchester and the Catalan Institut Català de Nanociència i Nanotecnologia (ICN2) in Barcelona, said, "This is the first-ever controlled study involving healthy people to demonstrate that very pure forms of graphene oxide—of a specific size distribution and surface character—can be further developed in a way that would minimize the risk to human health. ... Professor Bryan Williams OBE MD FMedSci, Chief Scientific and Medical Officer at the British Heart Foundation, added, "The discovery that this type of graphene can be developed safely, with minimal short term side effects, could open the door to the development of new devices, treatment innovations and monitoring techniques. We look forward to seeing larger studies over a longer timeframe to better understand how we can safely use nanomaterials like graphene to make leaps in delivering lifesaving drugs to patients." By The University of Edinburgh

𝐍𝐀𝐍𝐎𝐓𝐄𝐂𝐇𝐍𝐎𝐋𝐎𝐆𝐘 𝐈𝐍 𝐀𝐔𝐓𝐎𝐈𝐌𝐌𝐔𝐍𝐄 𝐃𝐈𝐒𝐄𝐀𝐒𝐄𝐒: 𝐀𝐃𝐕𝐀𝐍𝐂𝐄𝐒 𝐀𝐍𝐃 𝐀𝐍𝐀𝐋𝐘𝐒𝐈𝐒 In the realm of medical research, the application of nanotechnology in addressing autoimmune diseases represents a significant advancement. The review article titled "Recent advances of nanotechnology application in autoimmune diseases – A bibliometric analysis," authored by Rendong He, Li Li, Tingjun Zhang, Xuefeng Ding, Yan Xing, Shuang Zhu, Jun Gu, and Houxiang Hu, serves as an exemplary reference in this field. Published in Elsevier Nano Today, this article offers a comprehensive summary of the development and research priorities in nanotechnology for autoimmune diseases, backed by an insightful bibliometric analysis. 𝐊𝐞𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐑𝐞𝐯𝐢𝐞𝐰: 𝑩𝒊𝒃𝒍𝒊𝒐𝒎𝒆𝒕𝒓𝒊𝒄 𝑨𝒏𝒂𝒍𝒚𝒔𝒊𝒔 The authors have meticulously analyzed publications, influential countries/institutions, and journals related to nanotechnology in autoimmune diseases. Their findings reflect a growing worldwide interest, with major research focus areas being therapy, imaging, and sensors. 𝑵𝒂𝒏𝒐𝒕𝒆𝒄𝒉𝒏𝒐𝒍𝒐𝒈𝒚 𝒊𝒏 𝑫𝒊𝒂𝒈𝒏𝒐𝒔𝒊𝒔 𝒂𝒏𝒅 𝑻𝒉𝒆𝒓𝒂𝒑𝒚 The review emphasizes the emerging role of nanomaterials in diagnosis and therapy, including nano-biosensors and nanoprobes for imaging. These advancements are particularly crucial given the idiopathic and persistent nature of autoimmune diseases, where early detection and effective therapy are key to better management. 𝑪𝒉𝒂𝒍𝒍𝒆𝒏𝒈𝒆𝒔 𝒂𝒏𝒅 𝑪𝒍𝒊𝒏𝒊𝒄𝒂𝒍 𝑷𝒓𝒐𝒔𝒑𝒆𝒄𝒕𝒔 The authors highlight existing challenges and potential clinical applications, indicating that while significant progress has been made, further research is essential to fully harness the potential of nanotechnology in autoimmune disease treatment. 𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐅𝐮𝐭𝐮𝐫𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡: 𝑺𝒕𝒂𝒏𝒅𝒂𝒓𝒅𝒊𝒛𝒊𝒏𝒈 𝑴𝒂𝒏𝒖𝒇𝒂𝒄𝒕𝒖𝒓𝒊𝒏𝒈 𝒂𝒏𝒅 𝑨𝒑𝒑𝒍𝒊𝒄𝒂𝒕𝒊𝒐𝒏 𝑷𝒓𝒐𝒄𝒆𝒔𝒔𝒆𝒔 For the safe and effective use of nanotechnology, establishing standardized manufacturing and application processes is critical. This will not only improve clinical outcomes but also pave the way for broader clinical adoption. 𝑬𝒙𝒑𝒍𝒐𝒓𝒊𝒏𝒈 𝑻𝒊𝒔𝒔𝒖𝒆 𝑬𝒏𝒈𝒊𝒏𝒆𝒆𝒓𝒊𝒏𝒈 Nanotechnology-based tissue engineering emerges as a promising frontier, especially for end-stage autoimmune disease patients. This approach could offer new solutions for tissue regeneration, improving quality of life and survival rates. 𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧 𝐚𝐧𝐝 𝐅𝐮𝐭𝐮𝐫𝐞 𝐎𝐮𝐭𝐥𝐨𝐨𝐤 The review by He et al. marks a significant step in understanding the impact of nanotechnology on autoimmune diseases. It lays a foundation for future research directions and clinical translation, driving the field towards more innovative and effective solutions. #Nanotechnology #AutoimmuneDiseases #MedicalResearch #Innovation #Healthcare #Science #Research #BibliometricAnalysis #FutureOfMedicine #NanoToday

As a #nanomedicine lead scientist, I am privileged to work in a field that harnesses the power of #nanotechnology to revolutionize healthcare. In my research group, we focus on three key aspects that have the potential to reshape the way we understand and treat diseases: 1️⃣ **Studying Diseases with Nanotechnology**: Throughout history, the scientific community has dedicated centuries to studying diseases. However, the full potential of nanotechnology in disease research has only recently been realized. By understanding how our body deal with nanoscale components, such as albumin present in our bodies, we have a unique opportunity to deepen our understanding of diseases. My group is utilizing nanotechnology to study diseases like #inflammation, #cancer, and #aging. 2️⃣ **Developing Next-Generation Therapies**: Nanotechnology has emerged as a game-changer in delivering therapeutic agents effectively and safely to targeted cells. Many research groups, including ours, are at the forefront of developing novel formulations that utilize nanotechnology to deliver mRNA, siRNA, CRISPR, monoclonal antibodies, and more. Our collaborations with leaders in various fields aim to develop innovative treatments for rare diseases, infectious diseases, and cancer. 3️⃣ **Advancing Vaccine Development**: The role of nanotechnology in vaccine development cannot be overstated. During the recent pandemic, nanotechnology played a pivotal role in the creation of safe and effective mRNA vaccines for the general population. Looking ahead, we are excited about the potential of nanotechnology in developing universal vaccine formulations against coronavirus and other diseases, particularly in the field of cancer vaccines. In the posts to come, I will share insights from our published work, providing real-life examples for each aspect mentioned above. These posts will serve as valuable resources for students, junior scientists, and anyone interested in leveraging their skills in nanotechnology to drive groundbreaking scientific research. Stay tuned for more updates and let's embark on this exciting journey together! 🌟

This is a new way to work with single cells - alternative to microfluidics. Fits well with multi-omics approach; useful for cell line development too.

**DID YOU KNOW** Did you know that by introducing more stem cells into the body, you can experience a higher rate of healing and regeneration? More stem cells in the blood means that those cells will differentiate into several types of cells needed for repair - lung cells, skin cells, heart tissue, muscle issue, bone and even connective tissue. This is exactly what our company has done with their patented technology with the NATURAL stem cell activation PATCH that’s turns your Dormant Stem Cells back on. Through the process called Photo-Bio-Modulation, this wafer thin wearable patch causes your body to activate your dormant stem cells and it floods your body with young stem cells. The result is an unparalleled level of health and vitality. This is futuristic technology at its best! SEE THE DIFFERENCE, TAKE THE JOURNEY!

Interesting reading on #secretomic and #transcriptomic analysis that gives us another point of view when designing #celltherapy, defining #biomarker or new #targetedtherapies.

Nanotechnology in Health: Nanotechnology is transforming the landscape of medicine with groundbreaking innovations in diagnostics, therapeutics, and research tools. Introduction to Nanomedicine Nanomedicine harnesses the potential of nanotechnology to enhance human health. By designing nanoparticles between 1-100 nm, we can now target diseases at the molecular level, offering precision treatment and reducing adverse effects seen with conventional drugs. Current Therapeutic Landscape Traditional treatments, particularly for cancer and diabetes, often come with high toxicity and non-specificity. Nanotechnology is changing the game by enabling targeted drug delivery, enhancing efficacy, and minimizing side effects. Nanoparticles are being used as: - Contrast Agents - Fluorescent Materials - Molecular Research Tools - Targeted Drugs Therapeutic Innovations Nanotechnology ensures that even highly toxic drugs, such as cancer chemotherapeutics, can be delivered safely and effectively to specific tissues. Key Nanotechnology Platforms Liposomes: These spherical nanoparticles, with their lipid bilayer membranes, have revolutionized drug delivery since their discovery in the 1960s. They improve drug efficacy and safety, though rapid degradation by liver macrophages poses a challenge. Targeted Liposomal Therapy - Passive Targeting: Utilizes the leakiness of blood vessels in tumor tissues. - Active Targeting: Employs immunoliposomes with antibodies or ligands aimed at specific targets, enhancing precision and reducing side effects. Nanopores Since their introduction in 1997, nanopores have been game-changers in selective molecular passage and DNA sequencing, paving the way for cost-effective, high-throughput genome analysis. The Future of Nanomedicine Nanotechnology is set to play a pivotal role in future medical treatments. While potential toxicities of nanoparticles need further research, the advancements in nanomedicine promise significant improvements in disease treatment and human physiology enhancement. #Nanotechnology #HealthTech #MedicalInnovation #Nanomedicine #FutureOfHealthcare #CancerTreatment #PrecisionMedicine #Biotech #HealthcareRevolution

Development of micro-robots that can deliver medication to metastatic tumors Developed by engineers at the Engineers Without Border University of California San Diego, green algae cells are utilised to provide a transportation medium for microrobots, that move through the tissue in the lungs, in order to deliver cancer-fighting medication directly to cancerous tumours. The findings have been published in a paper by Science Advances. The development, has been the production of a collaboration between the labs of Joe Wang and Liangfang Zhang, both professors in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering at the UC San Diego Jacobs School of Engineering, which has seen the use of both biology and nanotechnology. In order to create the microrobots, the developers chemically attached nanoparticles, that were filled with the drug payload, to the surface of the green algae cells. The algae then disperse within the space of the lung tissue, allowing the nanoparticles to deliver their payload to the tumours. The nanoparticles themselves are made of biodegradable polymer spheres. These are then loaded with the required chemo drug, and coating with red blood cell membranes to prevent an immunological response from the patients immune system. In a statement, Zhengxing Li, PhD student and study co-first author, said: “This coating makes the nanoparticle look like a red blood cell from the body, so it will not trigger an immune response.” Regarding the study, it involved monitoring the responses of mice which had developed melanoma in the lungs. The microrobots were administered to the lungs via a small tube that was inserted into the windpipe. Treated mice experienced a media survival time of 37 days, in relation to the 27 day benchmark of untreated mice. “The active swimming motion of the microrobots significantly improved distribution of the drug to the deep lung tissue, while prolonging retention time,” said Li. “This enhanced distribution and prolonged retention time allowed us to reduce the required drug dosage, potentially reducing side effects while maintaining high survival efficacy.” The next phase of development will see the administering of the drug medium to larger animals with an eventual goal of human trials. 

SEC-seq: technique developed by Dino Di Carlo and colleagues to link protein secretion to gene expression at single cell level via use of nanovials.