Aslıhan Ek’s Post

Nanotechnology in Health: Nanotechnology is transforming the landscape of medicine with groundbreaking innovations in diagnostics, therapeutics, and research tools. Introduction to Nanomedicine Nanomedicine harnesses the potential of nanotechnology to enhance human health. By designing nanoparticles between 1-100 nm, we can now target diseases at the molecular level, offering precision treatment and reducing adverse effects seen with conventional drugs. Current Therapeutic Landscape Traditional treatments, particularly for cancer and diabetes, often come with high toxicity and non-specificity. Nanotechnology is changing the game by enabling targeted drug delivery, enhancing efficacy, and minimizing side effects. Nanoparticles are being used as: - Contrast Agents - Fluorescent Materials - Molecular Research Tools - Targeted Drugs Therapeutic Innovations Nanotechnology ensures that even highly toxic drugs, such as cancer chemotherapeutics, can be delivered safely and effectively to specific tissues. Key Nanotechnology Platforms Liposomes: These spherical nanoparticles, with their lipid bilayer membranes, have revolutionized drug delivery since their discovery in the 1960s. They improve drug efficacy and safety, though rapid degradation by liver macrophages poses a challenge. Targeted Liposomal Therapy - Passive Targeting: Utilizes the leakiness of blood vessels in tumor tissues. - Active Targeting: Employs immunoliposomes with antibodies or ligands aimed at specific targets, enhancing precision and reducing side effects. Nanopores Since their introduction in 1997, nanopores have been game-changers in selective molecular passage and DNA sequencing, paving the way for cost-effective, high-throughput genome analysis. The Future of Nanomedicine Nanotechnology is set to play a pivotal role in future medical treatments. While potential toxicities of nanoparticles need further research, the advancements in nanomedicine promise significant improvements in disease treatment and human physiology enhancement. #Nanotechnology #HealthTech #MedicalInnovation #Nanomedicine #FutureOfHealthcare #CancerTreatment #PrecisionMedicine #Biotech #HealthcareRevolution

#Nanotechnology - Recent advancements in the #medical field, particularly in #cancer treatment, #drug delivery, and #vaccine development. 👉Cancer Treatment - Researchers have developed nanorobots that can target and kill cancer cells more efficiently. One notable study demonstrated the use of a DNA-based nanorobot with a hidden weapon designed to seek out and destroy cancer cells in mice. This nanorobot can be further refined to increase its targeting accuracy by incorporating specific proteins or peptides on its surface, allowing it to bind to particular cancer types. (ScienceDaily) (Phys.org) 👉Nanoparticle-Based Vaccines - At MIT, scientists are exploring the use of metal-organic frameworks to enhance vaccine efficacy. In their studies on mice, they found that MOFs could encapsulate parts of the SARS-CoV-2 spike protein and act as an adjuvant to stimulate a robust immune response. This technology not only promises to improve the effectiveness of vaccines but also offers a potentially cheaper and easier-to-manufacture alternative to current mRNA vaccines, which could enhance global vaccine accessibility (MIT News). 👉Precision Medicine and Drug Delivery - Nanoparticle-based delivery systems are revolutionizing precision medicine. These systems can encapsulate drugs and deliver them directly to specific cells or tissues, minimizing side effects and increasing treatment efficacy. For instance, researchers have developed a microrobot-packed pill that shows promise for treating inflammatory bowel disease by delivering medication directly to the inflamed areas in the gastrointestinal tract. (ScienceDaily) 👉Computational Nanotechnology and Green Nanotechnology - Computational nanotechnology is enhancing the development of intelligent nanoparticles, which can be used in various applications, including drug delivery and environmental monitoring. Additionally, green nanotechnology practices are becoming more prevalent, focusing on sustainable nanoparticle synthesis methods and the use of biodegradable materials. These practices help reduce the environmental impact of nanotechnology while maintaining its benefits. (StartUs Insights) 👉Wearable Health Monitors - Innovations in nanotechnology are also advancing wearable health monitors. A recent development includes a wearable ultrasound patch that allows continuous, non-invasive monitoring of cerebral blood flow. This technology has significant implications for monitoring and managing conditions such as stroke and other cerebrovascular diseases. (ScienceDaily) #healthcare #innovation #technology #nantechnology #nanoparticle #materialscience #nanomaterials #nanorobotics #wearabletech #science #research

CURRENT AVENUES AND FUTURE PROSPECTS OF NANOBIOTECHNOLOGY Nanobiotechnology is an emerging field that is an intersection of Biotechnology and Nanotechnology. This field has and continues to achieve contribution from various scientific disciplines. Fundamentally, Nanobiotechnology focuses on the manipulation of materials at the nanosize level and successive combination with biomolecules. Nanostructured materials are now being used in various products, pharmaceuticals, cosmetics and industries. The potential of Nanobiotechnology to deal at the nanomolecular level has fostered the development of devices and products with high sensitivity and specificity thus improving performance of various processes, products and devices. Interestingly, nanomaterials function as more than mere tiny versions of the macromaterial. Nanomaterials possess physical and chemical properties different from those of the large-scale material. Their size is sufficiently small to the effect that quantum mechanics dictates some of their properties. Nanobiotechnology currently does and continues to find diverse application. Owing to the fact that nanomaterials are of the same scale as biological molecules, nanomaterials present their possibility of intervention in biological systems. Notably, this includes Medical Nanobiotechnology which permits diagnosis of diseases at an early stage and more cheaply. Additionally, there is hope for individuals having genetic disorders in that through medical nanobiotechnology, gene therapy is possible. Genetic disorders can be prevented or treated by correcting defective genes causative of genetic disorders by delivery of repaired genes or the replacement of defective ones. Through Nanobiotechnology, therapeutic efficacy and safety of drugs can be improved by controlling drug delivery to ensure accuracy of rate and target. This would incredibly reduce cases of medical toxicity and side effects. Notably, Nanobiotechnology presents great potential in effective cancer therapy. Nanoscale systems are also instrumental in the delivery of incompatible drugs. At a quantum level, the reaction of entities (electrons, atoms, molecules) is in response to the information provided to them in their environment. This principle finds expression on nanobiotechnological tissue engineering which aims to restore the normal function of organs and tissues previously diseased or injured. In harmony with the aforementioned principle, cells respond to nano information presented to them in their microenvironment ultimately achieving the goal of tissue regeneration (engineering). This overcomes limitations related to the use of allografts and xenografts. In the food sector, Nanobiotechnology is instrumental in pathogen detection. Nanobiotechnology provides an accurate nanodetection of food pathogens. This fields continues to evolve and present more scientific potential presently and in years to come. #Nanobiotechnology #nanotechnology #nanomedicine

This is a new way to work with single cells - alternative to microfluidics. Fits well with multi-omics approach; useful for cell line development too.

I think it is important to remember that it is still early days for single cell profiling. I was reviewing comment from AGBT - Advances in Genome Biology and Technology in 2017 and it struck me that there was a quote from Michael Talkowski about the future of single cell having the promise of revealing new insights and becoming mainstream. It has really only been a few years of single cell technologies being mainstream and we are just now seeing new technologies like Deepcell emerging in this space. The next 3 to 5 years should be exciting for both #singlecellanalysis and #spatialbiology

Interesting reading on #secretomic and #transcriptomic analysis that gives us another point of view when designing #celltherapy, defining #biomarker or new #targetedtherapies.

Development of micro-robots that can deliver medication to metastatic tumors Developed by engineers at the Engineers Without Border University of California San Diego, green algae cells are utilised to provide a transportation medium for microrobots, that move through the tissue in the lungs, in order to deliver cancer-fighting medication directly to cancerous tumours. The findings have been published in a paper by Science Advances. The development, has been the production of a collaboration between the labs of Joe Wang and Liangfang Zhang, both professors in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering at the UC San Diego Jacobs School of Engineering, which has seen the use of both biology and nanotechnology. In order to create the microrobots, the developers chemically attached nanoparticles, that were filled with the drug payload, to the surface of the green algae cells. The algae then disperse within the space of the lung tissue, allowing the nanoparticles to deliver their payload to the tumours. The nanoparticles themselves are made of biodegradable polymer spheres. These are then loaded with the required chemo drug, and coating with red blood cell membranes to prevent an immunological response from the patients immune system. In a statement, Zhengxing Li, PhD student and study co-first author, said: “This coating makes the nanoparticle look like a red blood cell from the body, so it will not trigger an immune response.” Regarding the study, it involved monitoring the responses of mice which had developed melanoma in the lungs. The microrobots were administered to the lungs via a small tube that was inserted into the windpipe. Treated mice experienced a media survival time of 37 days, in relation to the 27 day benchmark of untreated mice. “The active swimming motion of the microrobots significantly improved distribution of the drug to the deep lung tissue, while prolonging retention time,” said Li. “This enhanced distribution and prolonged retention time allowed us to reduce the required drug dosage, potentially reducing side effects while maintaining high survival efficacy.” The next phase of development will see the administering of the drug medium to larger animals with an eventual goal of human trials. 

The systemic view of cellular signaling cannot be overstated. The expression of mRNAs for cell surface markers or components of the secretome is simply "junk data" if the gene products do not reach the cell membrane or the extracellular matrix. The disparities between genomic data, IHC antibody detection, and patient outcomes for targetted therapies clearly demonstrate the need for a systemic approach. Try baking bread with eggs, flour, yeast, sugar, and water.....but NO oven. Ingredients alone do not equal finished products.

UCLA press release on our SEC-seq technique, which was published today in Nature Nanotechnology. We apply #nanovials, bowl-shaped microscale hydrogel particles, to detect the secretion of growth factor produced by thousands of individual cells and link this information to the gene expression signature of each of those same single cells. Surprisingly, we found that the mRNA level encoding for the growth factor, vascular endothelial growth factor (VEGF), responsible for induction of blood vessel formation and regeneration of tissue, did not correlate with the level of secretion. Instead we found another set of genes highly correlated with secretion that marked a small sub-population of cells with much higher secretion. We coined the term Vascular Regenerative Signal (VRS) to describe this signature. The VRS also contained some surface marker genes. Some of these genes were reflected by higher protein levels of the VRS cells, which we used to sort the VRS sub-population. The population maintained the highly secretory phenotype and surface marker over at least a week of culture - with implications for therapeutic use! These results should inform how we design the next generation of #celltherapies . Instead of just assuming that inserting a gene to drive higher mRNA levels will lead to more secreted proteins, we need to think about the cell as a holistic system that has other checks and controls on what it secretes and when. We believe this #functionfirst discovery approach can improve outcomes with cell therapies, by directly measuring the final cellular functions that drive therapeutic effect and developing a sophisticated understanding of its origins. SEC-seq stands for Secretion-Encoded single-Cell Sequencing. We designed the approach to be easily accessible to researchers and scientists around the world, since it leverages standard equipment like the 10x Genomics Chromium system with BioLegend's oligo-barcoded antibodies. Sorting of cell-loaded nanovials is conducted with a Sony Biotechnology Inc. SH800S sorter. Nanovials are available from Partillion Bioscience. Congratulations to Shreya Udani, Justin Langerman, Kathrin Plath, Joe de Rutte, Doyeon Felis Koo, SEVANA BAGHDASARIAN, Brian Cheng, Simran Kang, Citra Soemardy for the great teamwork to develop the technology and explore new frontier biology of translational importance. Reach out if you want to try SEC-seq - we'd be happy to help! #labonaparticle #nanotechnology #stemcells #celltherapy #cellandgenetherapy #singlecell #singlecellanalysis #cytometry #flowcytometry #biotechnology #secseq https://lnkd.in/g-uf7P5i

𝐑𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐌𝐚𝐫𝐤𝐞𝐭 𝐰𝐨𝐫𝐭𝐡 $49.0 𝐛𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 2028 Download PDF Brochure @ https://lnkd.in/dPnCniRW The global 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐦𝐚𝐫𝐤𝐞𝐭, 𝐯𝐚𝐥𝐮𝐞𝐝 𝐚𝐭 $16.0 𝐛𝐢𝐥𝐥𝐢𝐨𝐧 𝐢𝐧 2023, 𝐢𝐬 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐞𝐝 𝐭𝐨 𝐫𝐞𝐚𝐜𝐡 $49.0 𝐛𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 2028, 𝐠𝐫𝐨𝐰𝐢𝐧𝐠 𝐚𝐭 𝐚 𝐂𝐀𝐆𝐑 𝐨𝐟 25.1%. The global market is expected to benefit from the focus on #personalizedmedicines. Precision medicine is an approach to medical treatment that tailors therapeutics, and interventions for individual patients or a subpopulation based on their unique genetic, environmental, and lifestyle characteristics. the 𝐅𝐃𝐀 𝐚𝐩𝐩𝐫𝐨𝐯𝐞𝐝 12 𝐩𝐞𝐫𝐬𝐨𝐧𝐚𝐥𝐢𝐳𝐞𝐝 𝐦𝐞𝐝𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬, 𝐫𝐞𝐩𝐫𝐞𝐬𝐞𝐧𝐭𝐢𝐧𝐠 𝐚𝐩𝐩𝐫𝐨𝐱𝐢𝐦𝐚𝐭𝐞𝐥𝐲 34% of all newly approved therapeutic molecular entities. Personalized treatments account for at least a quarter of new drug approvals since 2015. Moreover, five new gene or #cellbased therapies were approved in 2022. These include treatment of rare #geneticdisorders with few other treatment options – #betathalassemia, #hemophiliaB, and cerebral adrenoleukodystrophy, refractory multiple #myeloma, and certain types of non-muscle invasive #bladdercancer. 𝐄𝐧𝐭𝐞𝐫𝐩𝐫𝐢𝐬𝐞𝐬 𝐨𝐩𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐰𝐢𝐭𝐡𝐢𝐧 𝐭𝐡𝐢𝐬 𝐢𝐧𝐝𝐮𝐬𝐭𝐫𝐲: Vidacel      Qkine      Rohto-Mentholatum (VN)      Merrick Biotech      Fluicell      Kimera Labs Inc      UCLA Broad Stem Cell Research Center      Smart BioMaterials Consortium (SBMC)      Orthocell Ltd    PL BioScience GmbH     Future Science Group      minoHealth AI Labs      AMSBIO      Avay Biosciences      BioGrademy  Athenaeum Scientific Publishers      Myo Palate Stempeutics Research Private Limited      RegMed XB    Acorn Biolabs      Donnelly Centre for Cellular and Biomolecular Research, University of Toronto     ClexBio   BPB MEDICA™      Advanced Cell Therapy and Research Institute, Singapore (ACTRIS)      Morphocell Technologies      Xintela AB     Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University Department of Physiology, Anatomy & Genetics - University of Oxford      Gallant Therapeutics      National Center for Cell Science      Cedars-Sinai Biomanufacturing Center      LongevityTech.fund      Cellphire Therapeutics, Inc.     Angelantoni Life Science S.r.l.      3d.FAB platform