Association for Single Cell Analysis (ASCA)’s Post

Here's just one of many examples showcasing the crucial role of organ-on-chip technology in accelerating preclinical research and cutting costs. Organ-on-chip platforms like this are revolutionizing drug screening and preclinical studies, offering faster and more cost-effective solutions compared to traditional methods. #OrganOnChip #PreclinicalResearch #DrugScreening

Single cell transcriptomics provides unparalleled insights into the diverse cell types within complex samples, like tissues or organoids. By analyzing individual cells, it reveals the intricate cellular landscape and uncovers critical differences in cell types affected by diseases or treatments. Reach out to Zenit Science for top-notch single-cell transcriptome services. Turn your data into actionable insights and propel advancements in translational medical research. https://lnkd.in/dyAy3mVH #zenitscience Magnar Bjørås Mirta Sousa Jing Ye Vidar Saasen Emily Helgesen James Booth Henrik Høyer María Cámara Quílez Elias Z. Erik Vinther Peter Horn Møller Marigold Innovation Figure: Single-cell transcriptome analysis of heart organoids derived from healthy individuals and patients with severe genetic heart conditions. Data analyzed at different developmental stages reveal major differences in cell type populations in controls and patients, highlighting the impact of pathogenesis in the developing heart organoids over time.

Cell surface RNAs recruit neutrophils to inflammatory sites. Researchers have discovered a crucial role for cell surface RNAs, particularly glycoRNAs, in recruiting neutrophils to inflammatory sites. Neutrophils, integral to the immune system, utilize glycoRNAs to bind to endothelial cells and migrate through blood vessel walls to reach sites of inflammation. Previous studies have identified glycoRNAs in various cell types, suggesting their broad significance across different biological contexts. These findings highlight the potential of glycoRNAs in facilitating cell-cell interactions and inflammatory responses, opening avenues for further exploration into their functions and mechanisms in diverse cellular processes. Source: #rna #inflammation #immunesystem #biology #medical

Curious about single-cell transcriptomics? This groundbreaking technology allows us to study gene expression at the level of individual cells, providing unprecedented insights into cellular heterogeneity, developmental processes, and disease mechanisms. Learn more at Zenit Science.

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The many uses of mini-organs This week, we reported on a team of researchers who managed to grow lung, kidney, and intestinal organoids from fetal cells. Because these tiny 3D cell clusters mimic…

Under the status quo, it costs approx. $5Billion (you read that right) and 15 years to develop a gene therapy product! Finding the pertinent negative faster has never been more important and thats where Emulate, Inc. Organ-On-Chip technology can help! Utilizing organ chips as an alternative to traditional methods to down select candidates and de-risk the development process can represent significant savings - lets talk about it. #cgt #ascgt #organonchip

Check out this amazing LNP Cost calculator: https://lnkd.in/dZ6vjT2V In a simple cost analysis, Moderna was able to screen 35 novel LNPs in the Liver-Chip during a course of experiments that took 18 months at a total cost of $325,000. If they were to screen the same number of LNPs using traditional NHP studies, it would have cost Moderna over $5,000,000 and taken over 60 months to complete. Simply by incorporating Liver-Chips into their workflow, Moderna was able to down-select LNPs over 4x faster and at a fraction of the cost of NHP studies. Learn more by watching Dr. Atkins’ full presentation -> https://lnkd.in/d4kVSXAv

Comparative immunhistology (DIC DAB) of transgenic mouse strains overexpressing my mystery protein, with identical ages but varying relative copy numbers, in comparison to wild-type brains. These strains exhibit progressively increasing protein deposition and neurodegeneration. Given the convincing nature of these results, I may consider publishing them at one stage. I have many more results that are also very convincing. What do you think?

Struggling to recreate the human physiology in vitro? 💬 We have interviewed Natalia Sánchez Romero, R&D Director at BeCytes, who has given some insights about the necessity of creating in vitro models that approximate in vivo behavior and BeCytes options to recreate the hepatic microenvironment. BeCytes has developed a cell procuring service that offers liver cells, including both primary hepatocytes and non-parenchymal cells. These cells enable the creation of reliable 3D liver models for research purposes. Our cells are produced under rigorous QC standards and fully characterized, including 3D/spheroid qualification. 🔵 Don't miss it! https://lnkd.in/dvW-Vs2v #livermodels #cellculture #hepaticcells #BeCytesBiotechnologies

Pain hypersensitivity includes molecular mediation of transient receptor potential canonical 5 (TRPC5) channels in rodent and human sensory neurons,suggesting inhibition of TRPC5 to reduce experience of pain.(Science Translational Medicine 5/26/2021)