Rodrigo Lima’s Post

Curious about single-cell transcriptomics? This groundbreaking technology allows us to study gene expression at the level of individual cells, providing unprecedented insights into cellular heterogeneity, developmental processes, and disease mechanisms. Learn more at Zenit Science.

🔔 Out now! Our blog post detailing the culture of primary human hepatocytes in both 2D and complex models for the advancement of drug discovery, ADME, toxicity, DDI, and tissue engineering. https://lnkd.in/eHQmdhVF Talk with our experts to discover how to leverage our primary human hepatic cells to empower your sciences: info@mosaiccellsci.com

Mitigation of TDP-43 toxic phenotype in amyotrophic lateral sclerosis models In virtually all ALS patients, a protein called TDP-43 is responsible for forming abnormal clumps within cells, which causes cell death. In recent years, The team discovered a second protein, called RGNEF, with functions that are opposite to TDP-43. The team’s latest breakthrough identifies a specific fragment of that RGNEF protein, named NF242, that can mitigate the toxic effects of the ALS-causing protein. The researchers discovered that when the two proteins interact with each other, the toxicity of the ALS-causing protein is removed, significantly reducing damage to the nerve cell and preventing its death. In fruit flies, the approach notably extended lifespan, improved motor functions and protected nerve cells from degeneration. Similarly, in mouse models, the approach led to enhanced lifespan and mobility, along with a reduction in neuroinflammation markers. #ScienceMission #sciencenewshighlights https://lnkd.in/dyGAu3Dt

Scientists use three-dimensional cell culture models, such as organoids, to replicate an organ’s functionality and structure in vitro. However, researchers with limited experience often find it challenging to develop organoid models. In this webinar brought to you by Sartorius, Aitor Aguirre, Ph.D. will explain how his group produces mini hearts and uses these organoids to investigate development and disease. Register today #AD: https://ow.ly/ksgt50RuaVU

Single cell transcriptomics provides unparalleled insights into the diverse cell types within complex samples, like tissues or organoids. By analyzing individual cells, it reveals the intricate cellular landscape and uncovers critical differences in cell types affected by diseases or treatments. Reach out to Zenit Science for top-notch single-cell transcriptome services. Turn your data into actionable insights and propel advancements in translational medical research. https://lnkd.in/dyAy3mVH #zenitscience Magnar Bjørås Mirta Sousa Jing Ye Vidar Saasen Emily Helgesen James Booth Henrik Høyer María Cámara Quílez Elias Z. Erik Vinther Peter Horn Møller Marigold Innovation Figure: Single-cell transcriptome analysis of heart organoids derived from healthy individuals and patients with severe genetic heart conditions. Data analyzed at different developmental stages reveal major differences in cell type populations in controls and patients, highlighting the impact of pathogenesis in the developing heart organoids over time.

🔸 Single-cell multiomics analysis of myelodysplastic syndromes and clinical response to hypomethylating therapy Campillo-Marcos et al. used single-cell technologies to simultaneously map the genome and immunoproteome of myelodysplastic syndromes (MDS) throughout clinical evolution. Key points 📍The architecture and evolution of molecular clones in precious paired bone marrow MDS samples at diagnosis and posttreatment 📍A combined imbalance of specific cell lineages with diverse mutational profiles associated with the clinical response to hypomethylating therapy. ➡ More details: https://lnkd.in/eTCF9u5P #spatialomics #spatialbiology #singlecellanalysis #singlecell

𝗔𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗧𝗿𝗮𝗻𝘀𝗽𝗼𝗿𝘁𝗲𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝘁 𝗖𝘂𝗿𝗲 𝗖𝗟𝗖𝗡𝟰 𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 🧑🏫 Join us at the Cure CLCN4 Annual Scientific Meeting to learn how our SURFE2R platforms can enhance your research on CLC channels and transporters. Connect with Giovanna De Filippi, our Business Development Manager, and discover how our cutting-edge technology can drive your research forward. 𝗪𝗵𝘆 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿𝘀: CLCN4-related conditions are exceptionally rare, with just over 120 identified cases worldwide. These conditions need urgent and extensive research to uncover the basic biology of the CLC-4 protein and develop potential therapies. Supporting the Cure CLCN4 Annual Scientific Meeting aligns with our commitment to advancing scientific understanding and improving therapeutic options for patients. We are proud sponsors of the poster session, and look forward to see all the innovative research that is currently happening around CLC transporters. Join us in our mission to advance membrane transporter research and improve lives. Connect with us at the event and learn how we can support your research endeavors. Want to learn more about CLCN4-related conditions? Read more here https://ow.ly/iIqJ50RXWkw #CLCN4 #SSME #SURFE2R #MembraneTransporters #IonChannels #RareDisease #Electrophysiology #Carefortherare

🔬 A recently published study by Nadjar et al. in Science Signaling introduces an optogenetic method to activate inflammasomes, inducing pyroptosis – a form of programmed cell death. Their tool allows precise manipulation of inflammasome activation, shedding light on cellular mechanisms. More on their method 👉 https://lnkd.in/deZ8fyV4 #Science #Inflammasomes #Pyroptosis 🧬🔦

Discover the groundbreaking B6-hIL-17A Mouse Model for advancing psoriasis research and treatment development. 🌟 Psoriasis affects millions worldwide, impacting quality of life and causing physical and psychological distress. Cyagen's B6-hIL-17A Mouse Model offers a platform for targeted research into the IL-23/17 pathway, crucial in promoting inflammation and overproduction of skin cells in psoriasis. The model aids in understanding psoriasis mechanisms, testing interventions, and simulating disease progression. Additionally, research using the model focuses on genetic diversity and precise measurement techniques for severity assessment. Join the conversation by sharing your thoughts on the potential of the B6-hIL-17A Mouse Model in revolutionizing psoriasis research. 💪 #Psoriasis #mousemodel #scienceandtechnology #biotech #biotechnology #bioscience #researchmatters #research #preclinicalresearch #cyagen #humanized #diseaseresearch

➡️Molecular mechanism of Mitochondrial dynamics:⤵️ "Understanding mitochondrial dynamics is crucial for cellular health. The delicate balance between mitochondrial fusion and fission regulates key processes such as energy production, apoptosis, and autophagy. This molecular machinery not only drives cell survival but also plays a pivotal role in aging and disease. The visualization of these complex interactions highlights the importance of mitochondrial function in cell fate decisions. #Mitochondria #CellBiology #MolecularMechanisms #BioTech"