Ascidian Therapeutics’ Post

🌟 Exciting News! 🌟 We're thrilled to announce the publication of our latest research in Nature Portfolio #NatureCommunications: "m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation." After five years of hard work and dedication, we've uncovered a new layer of gene regulation in human neuronal development. Collaborating with The Francis Crick Institute and UCL, our study reveals how m6A methylation directs an essential protein's function, controlling neuronal shape and synaptic connections in humans. This discovery significantly advances our comprehension of neuronal function, paving the way for improved therapies for neurodegenerative disorders. Massive shout-out to everyone involved. Harry Crook Jasmine Harley Marija Petrić Howe Anob Chakrabarti Raphaëlle Luisier Rickie Patani https://lnkd.in/eRwAzXGC #Neuroscience #Neurodegeneration #RNA #m6A #Epitranscriptomics #Therapeutics #Bioinformatics #Multiomics

We sat down with Scripps Research Institute’s Dr. Jeanne Loring to discuss the current state and exciting future of cell and gene therapy, as well as how she believes #OGM is driving innovation in these applications. 💡 Learn more about Dr. Loring’s pioneering research in iPSCs and how OGM is helping to redefine safety considerations in our latest blog: https://lnkd.in/grBFiSrU

The field of cardiovascular medicine is rapidly evolving, with researchers exploring innovative treatment approaches to address complex heart and vascular conditions. Novel therapies leveraging gene editing, stem cell technologies, and regenerative medicine techniques hold promise for targeting the fundamental mechanisms of diseases like heart failure, atherosclerosis, and arrhythmias. These emerging strategies aim to improve patient outcomes and quality of life beyond what is possible with current standard-of-care interventions.  What are the most exciting or promising emerging therapeutic strategies in cardiovascular diseases? Share your thoughts with me down below. #CardiovascularMedicine #InnovativeTherapies #RegenerativeTreatments #FutureOfHeartHealth

The field of cardiovascular medicine is rapidly evolving, with researchers exploring innovative treatment approaches to address complex heart and vascular conditions. Novel therapies leveraging gene editing, stem cell technologies, and regenerative medicine techniques hold promise for targeting the fundamental mechanisms of diseases like heart failure, atherosclerosis, and arrhythmias. These emerging strategies aim to improve patient outcomes and quality of life beyond what is possible with current standard-of-care interventions.  What are the most exciting or promising emerging therapeutic strategies in cardiovascular diseases? Share your thoughts with us down below. #CardiovascularMedicine #InnovativeTherapies #RegenerativeTreatments #FutureOfHeartHealth

"The IPS-cell or Induced Pluripotent Stem-cell can possible can become therapeutic subject to study." Let's say, Transcription regulators are the majorly focused in current study of cell differentiation and regulation. However, it is experimentally found to regulate the cell differentiation even by induced artificial gene regulators/transcription factor. For example, Inducing the eye factors of Drosophila to somatic cell lead to eye like organ formation at the leg in larva stage. Even some of the master regulators such as, Oct4, Sox2, Klif4 etc. are cause to turnover somatic cell to intermediary IPS-cell. In fact, all of them are self activators and each other. Following up, the people with challenged by nerve or liver diseases, may be blessed with advanced study outcome of IPS-cell therapies. Ref: 1. Abou-Saleh, H., Zouein, F.A., El-Yazbi, A. et al. The march of pluripotent stem cells in cardiovascular regenerative medicine. Stem Cell Res Ther 9, 201 (2018). https://lnkd.in/gABbsrns 2. The Molecular Biology of the Cell. Bruce et al. #MolecularBiology #IPScell #Transcription #GeneRegulation #ResearchStudy

- Mesenchymal Stem Cells (MSCs) are unsung heroes in regenerative medicine, drug therapy, and cell and gene therapy research.  - Discover the power of versatile adult stem cells – self-renewal, immune regulation, anti-inflammatory, and cell differentiation capabilities unite for groundbreaking treatments. - Adult bone marrow extraction poses challenges, including weak cell adhesion and slow proliferation, leading to potential project delays. . Imagine a world where scientists have access to a powerful tool that improves treatment efficiency, opens doors to advanced technologies, and saves lives. This is the promise of mesenchymal stem cells (MSCs). . Join us as we explore the fascinating world of MSCs, delving into their potential and the challenges we face. Learn how these remarkable cells can revolutionize healthcare and foster a global research community united by knowledge and expertise. . References :  https://lnkd.in/gHVckGSi  https://lnkd.in/dWKhrx9   https://lnkd.in/gjzSJB59  https://lnkd.in/gKSEuk2X #Atlantis #BenchtoBed #AtlantisBioscience #DiscoverSolutions #TranslationalSolutions #Drug #DrugDevelopment #MSCs #MesenhymalStemCells #CellandGeneTherapy #CellTherapy #GeneTherapy #Cell #Gene #RegenerativeMedicine #Research #ResearchandDevelopment #StemCell #Exosome #SeneScenceMatters

🚨From from the field🚨Chelsey Derderian-LeBlang and colleagues in the lab of Rosalind A Segal at Dana-Farber Cancer Institute with collaborators at Harvard Medical School and National Center for Advancing Translational Sciences (NCATS) discovered that co-culturing hiPSC-derived sensory neurons (iSNs) with rodent dorsal root ganglion satellite glia (rSG) significantly advances their maturation. 🔬 Key Findings: Morphological Advancements: Co-cultured sensory neurons develop a pseudounipolar morphology through contact with rSGs, driven by semaphorin-plexin guidance cues and glial gap junction signaling. Functional Enhancements: iSNs in co-culture exhibit enhanced spontaneous action potential firing, more mature gene expression, and increased susceptibility to paclitaxel-induced axonal degeneration. This breakthrough provides a more physiologically relevant model to study human peripheral neuropathies and could pave the way for novel therapeutic strategies. Read the full article here: https://lnkd.in/gEK3_rh6 #NotYourAverageNeuron #CompleteTheCircuit #StemCellResearch #Neuroscience #PeripheralNeuropathies

A breakthrough gene therapy developed by scientists at Umeå University shows remarkable success in slowing the progression of amyotrophic lateral sclerosis (ALS) in a patient with an aggressive form of the disease caused by a mutation in the SOD1 gene. After four years of treatment, the patient maintains functional abilities such as climbing stairs and speaking, defying initial prognoses. This promising development underscores the potential of the therapy to significantly improve the lives of ALS patients, although further research is needed to optimize dosage and understand its broader applicability across different types of ALS. #ALSResearch #GeneTherapy #NeurologyBreakthrough #MedicalInnovation #RareDisease #HealthTech #Neuroscience #MedicalAdvancements #SOD1Mutation #ClinicalTrials https://lnkd.in/eHn-UVah

I am obviously passionate by #lifescience and #biotechnology, but also, surprisingly or not, interested in #spacetechnology and #spaceexploration. Both fields are quite hot these weeks with SpaceX launching finally into space its reusable Starship after the 3rd attempt, opening for humanity deep space travel possibilities in the coming years. In parallel, we are seeing the next generation of therapies, which are focusing on disease modification or cure of diseases, coming to the patients. Last approved by FDA is Orchard Therapeutics’ atidarsagene autotemcel, a gene therapy aiming to cure early-onset metachromatic leukodystrophy that affects around one in 100 000 births. To have seen the dramatic unavoidable fatal outcome of this gene mutation, while working in neuropediatrics in Paris, gives me even more hope for other deemed incurable diseases. What impresses me the most is the long term outcomes and the disease modification aspects. See the link to one of the paper published in #TheLancet 2 years ago. We are living in exciting times for science. Happy Easter! https://lnkd.in/dxr9uHMQ