Atlas Antibodies’ Post

Check out our new study: "Single-Cell Multi-Omics Map of Cell Type-Specific Mechanistic Drivers of Multiple Sclerosis Lesions." We identified a unique genetic signature in oligodendrocytes and spatially distinct metabolic changes in astrocytes at chronic active lesions in patients with progressive multiple sclerosis. Read more here: https://lnkd.in/eXfF2vXp #MultipleSclerosis #Neuroscience #SingleCellResearch

are GLP1 agonists a miracle drug?🎉🔬 I recently read a groundbreaking preprint demonstrating the remarkable potential of GLP1 receptor agonism in battling Parkinson's disease. This cutting-edge research reveals how the GLP1 receptor agonist, exenatide, not only restores insulin signaling and reduces oxidative stress but also improves mitochondrial functionality and decreases α-synuclein aggregation. 🧬💊 The findings, based on in-depth in vitro and clinical studies, including iPSC models and data from a Phase 2 trial, shed light on the mechanism behind the neuroprotective effects of exenatide, offering hope for a disease-modifying approach to synucleinopathies. By enhancing neuronal viability and reducing glial inflammation, this strategy opens new avenues for treating Parkinson's disease, moving us one step closer to turning the tide against this challenging condition. 💡🙌 read the preprint in: https://lnkd.in/eqiHYfpX #ParkinsonsResearch #Neuroscience #InnovationInHealthcare #ClinicalTrials #ScientificBreakthrough #GLP1Agonism #EndParkinsons

Vala Sciences is going to #SfN2023 in Washington DC! 🧠 🔬 🧠 Stop by our posters to learn more about our high-content, single-cell phenotypic screening assays for #neurotoxicty and #epilepsy Thank you Kara Gordon, Christine Gjerdrum Rines, Nicole A. Suarez, Ameena Pascua, and Md Fayad Hasan for all your hard work in developing these assays! PSTR202.20  Board X1 on November 13, 8AM-12AM session 2D and 3D iPSC-derived platforms for neurotoxicity screening demonstrate compound effects on calcium activity, synapses, viability and cell proliferation PSTR514.12  Board A10 on November 15, 1-5PM session Anti-retroviral therapy is toxic to iPSC-derived NPC's in vitro and alters neuronal calcium transients in differentiated NPCs PSTR526.17 Board E28 on November 15, 1-5PM session "Epilepsy in a dish" (EIDA): a suite of assays to discover therapeutics of epilepsy using isogenic hiPSC-neuron/astrocyte/microglia 2D and 3D tri-cultures and kinetic imaging cytometry #highthroughput #drugdiscovery #drugdevelopment #neuroscience

🔬Citation Break!📖 This citation investigates the effects of beta-amyloid oligomers on microglial samples for Alzheimer’s Disease research. rPeptide Beta-Amyloid 1-42 HFIP (Cat# A-1163) was used to generate the oligomers for the authors’ experiments. rPeptide also offers Preformed Fibrils generated from our Beta-Amyloid 1-42 (Cat# AF-1002) for customers wishing to use this reagent in their research without the need to create fibrils themselves. Paper: https://rb.gy/nnitox BA(1-42) HFIP: https://rb.gy/gnukbm #Research #Development #rPeptide #Beta #Amyloid #NeuroSciences #Alzheimers

New research showing that α-synuclein protein, a hallmark of Parkinson's disease, may be transferred from gut mucosal cells to the vagus nerve and dorsal motor nucleus. The study used newly engineered transgenic mice with restricted and inducible pathological human α-synuclein expression in intestinal epithelial cells, providing evidence for gut mucosal cells as a potential non-neuronal source of fibrillar α-synuclein protein. Check out the link to learn more. #ParkinsonsDisease #neuroscience #research

Explore a new perspective on Parkinson's disease! 🧠🌐 The latest research "Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson's disease," delves into the diversity of midbrain dopamine neurons, providing insights into the complex symptoms of Parkinson's. The authors analyze different subtypes of neurons, unveiling the intricate mechanisms behind the disease. Read the full article by clicking the link: https://lnkd.in/gKyaek2M 🚀 #ParkinsonsResearch #Neuroscience #ScientificAdvancements

#nose_to_brain_drug_delivery As a pharmacist delving into neuropharmacology, I am excited to present our recent article on Heliyon. It's about the potential effects of resveratrol on the rat model of MCAO. Resveratrol is a natural phenolic compound widely found in plants. Previous studies have suggested its neuroprotective role in cerebral ischemia due to its anti-oxidative, anti-inflammatory, and anti-apoptotic effects. Intranasal administration of resveratrol enhances its capacity to penetrate the blood-brain barrier, increasing therapeutic efficacy and safety. #Resveratrol #Neuroscience #Neuropharmacology #drugdelivery

☑️ *READ ABSTRACT BELOW:* Part 2: Results: Using 3D ex vivo organoid culture protocol, we successfully established 27 HNCOs from 39 patients with an overall success rate of 70% (27/39). Their mutational profiles were highly concordant, with three of the HNCOs analyzed showing greater than 70% concordance. Only one HNCO displayed less than 50% concordance. However, many of these organoid lines displayed clonal evolution during serial passaging, although major cancer driver genes and VAF distributions were shared between early and later passages. We also found that all late passages of HNCOs tended to be more sensitive to radiation than early passages, similar to drug response results. Conclusions: We report the establishment of HNCO lines derived from 27 patients and demonstrate their genetic concordance with corresponding parental tumors. Furthermore, we show serial changes in mutational profiles of HNCO along with long passage culture and the impact of these clonal evolutions on response to radiotherapy. Choi SY, Oral Oncol. 2023 Nov;146:106571. doi: 10.1016/j.oraloncology.2023.106571. Epub 2023 Sep 21. PMID: 37741019. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Identification of genetic modifiers of soluble TREM2 levels in CSF of Alzheimer’s patients. TREM2 participates in microglial activation, survival, and apoptosis, as well as in Alzheimer’s disease (AD) pathogenesis. Researchers investigated the genetics of soluble TREM2 (sTREM2), a protein involved in Alzheimer's disease (AD). They identified four new genetic regions associated with sTREM2 levels and AD risk, including a regulatory variant in a microglia-specific chromatin loop in the TGFR2 promoter and in NECTIN2. The study provides insights into TREM2 biology and suggests TGFBR2 and NECTIN2 as potential targets for AD treatment. https://lnkd.in/eW8HM3du #genetics #genomics ##precisionmedicine #genomicmedicine #gwas #omics #brain #neurology #neurodegeneration #neuroscience #alzheimer #dementia #longevity #aging #biomarkers #therapeutics #biotechnology #innovation #research #science ##sciencecommunication

【Cited FineTest ELISA Kit】4-HNE ELISA Kit | Redox Biology | IF: 10.7 Abstract: FineTest 4-HNE ELISA Kit is cited by an article entitled "BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation" Published in Redox Biology. Read Full Text: https://bit.ly/4fSyqzS Keywords: #Hemorrhage, #Stroke, #CognitiveHealth, #Neuroscience, #BrainHealth