We've had a fantastic response to our newest product! Make sure to check out the fastest and most affordable human iPSC-derived astrocytes on the market! We recently announced our new axoCells™ Astrocytes line (ax0704) designed to fuel robust in vitro models for neurodegenerative disease research and drug discovery. With labs around the world increasingly moving to in vitro models, drug discovery researchers are embracing human iPSC-derived cells to build more human, more functional models for neuroscience. But with many labs still using rat astrocytes for their work (with very long protocols, some even >100 days), we're "supporting the switch" to human iPSCs with this new axoCells Astrocytes product that can drive faster, cheaper in vitro workflows. Key highlights of our new axoCells Astrocytes product include: • Best price on the market • Derived from fibroblasts taken from a healthy 40-50-year-old male donor • Assay ready in just 48 hours • Express seven key markers of primary human astrocytes including GFAP, AQP4 and S100B and astrocyte-associated markers (EAAT1 and ALDH1L1) with low levels of neuronal progenitor markers including Nestin • Specifically developed for use in powerful in vitro monoculture models and complex co-culture systems for drug discovery Bolstered by our world-leading ISO 9001-accredited manufacturing processes, we are delighted to pass on further cost savings to you. Our new ax0704 astrocytes are cheaper than previous astrocytes and are priced at just £660 / $830 / €770 per vial (1 million cells)- the best price on the market! Click here to read more about this new product line and how you can use axoCells Astrocytes to power robust, physiologically relevant models of Alzheimer’s Disease, Parkinson’s Disease and ALS: https://hubs.la/Q02BjWkX0 Want to explore the details and get a quote? Click here: https://hubs.la/Q02BjWpy0 #iPSCs #Astrocytes #AlzheimersDisease #ParkinsonsDisease #ALS #DrugDiscovery
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CEO of Axol Bioscience, enabling “Better Human Disease Models” with iPSC technology in neurodegenerative, eye, cardiac, pain and skin disease
NEW PRODUCT ALERT! axoCells ASTROCYTES Key highlights of our new axoCells Astrocytes product include: • Best price on the market • Derived from fibroblasts taken from a healthy 40-50-year-old male donor • Assay ready in just 48 hours • Express seven key markers of primary human astrocytes including GFAP, AQP4 and S100B and astrocyte-associated markers (EAAT1 and ALDH1L1) with low levels of neuronal progenitor markers including Nestin • Specifically developed for use in powerful in vitro monoculture models and complex co-culture systems for drug discovery Bolstered by our world-leading ISO 9001-accredited manufacturing processes, we are delighted to pass on further cost savings to you. Our new ax0704 astrocytes are cheaper than previous astrocytes and are priced at just £660 / $830 / €770 per vial (1 million cells)- the best price on the market! Click here to read more about this new product line and how you can use axoCells Astrocytes to power robust, physiologically relevant models of Alzheimer’s Disease, Parkinson’s Disease and ALS: https://hubs.la/Q02BjWkX0 Want to explore the details and get a quote? Click here: https://hubs.la/Q02BjWpy0 #drugdiscovery #drugdevelopment #ipsc #cellculture #biopharma #neuroscience #biotech #stemcells #humancells #pharma #MPS #organoids
We've had a fantastic response to our newest product! Make sure to check out the fastest and most affordable human iPSC-derived astrocytes on the market! We recently announced our new axoCells™ Astrocytes line (ax0704) designed to fuel robust in vitro models for neurodegenerative disease research and drug discovery. With labs around the world increasingly moving to in vitro models, drug discovery researchers are embracing human iPSC-derived cells to build more human, more functional models for neuroscience. But with many labs still using rat astrocytes for their work (with very long protocols, some even >100 days), we're "supporting the switch" to human iPSCs with this new axoCells Astrocytes product that can drive faster, cheaper in vitro workflows. Key highlights of our new axoCells Astrocytes product include: • Best price on the market • Derived from fibroblasts taken from a healthy 40-50-year-old male donor • Assay ready in just 48 hours • Express seven key markers of primary human astrocytes including GFAP, AQP4 and S100B and astrocyte-associated markers (EAAT1 and ALDH1L1) with low levels of neuronal progenitor markers including Nestin • Specifically developed for use in powerful in vitro monoculture models and complex co-culture systems for drug discovery Bolstered by our world-leading ISO 9001-accredited manufacturing processes, we are delighted to pass on further cost savings to you. Our new ax0704 astrocytes are cheaper than previous astrocytes and are priced at just £660 / $830 / €770 per vial (1 million cells)- the best price on the market! Click here to read more about this new product line and how you can use axoCells Astrocytes to power robust, physiologically relevant models of Alzheimer’s Disease, Parkinson’s Disease and ALS: https://hubs.la/Q02BjWkX0 Want to explore the details and get a quote? Click here: https://hubs.la/Q02BjWpy0 #iPSCs #Astrocytes #AlzheimersDisease #ParkinsonsDisease #ALS #DrugDiscovery
New product launch: new line, lower price axoCellsTM Astrocytes for better neurodegenerative disease modeling
axolbio.com
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We've had a fantastic response to our newest product! Make sure to check out the fastest and most affordable human iPSC-derived astrocytes on the market! We recently announced our new axoCells™ Astrocytes line (ax0704) designed to fuel robust in vitro models for neurodegenerative disease research and drug discovery. With labs around the world increasingly moving to in vitro models, drug discovery researchers are embracing human iPSC-derived cells to build more human, more functional models for neuroscience. But with many labs still using rat astrocytes for their work (with very long protocols, some even >100 days), we're "supporting the switch" to human iPSCs with this new axoCells Astrocytes product that can drive faster, cheaper in vitro workflows. Key highlights of our new axoCells Astrocytes product include: • Best price on the market • Derived from fibroblasts taken from a healthy 40-50-year-old male donor • Assay ready in just 48 hours • Express seven key markers of primary human astrocytes including GFAP, AQP4 and S100B and astrocyte-associated markers (EAAT1 and ALDH1L1) with low levels of neuronal progenitor markers including Nestin • Specifically developed for use in powerful in vitro monoculture models and complex co-culture systems for drug discovery Bolstered by our world-leading ISO 9001-accredited manufacturing processes, we are delighted to pass on further cost savings to you. Our new ax0704 astrocytes are cheaper than previous astrocytes and are priced at just £660 / $830 / €770 per vial (1 million cells)- the best price on the market! Click here to read more about this new product line and how you can use axoCells Astrocytes to power robust, physiologically relevant models of Alzheimer’s Disease, Parkinson’s Disease and ALS: https://hubs.la/Q02BjVV50 Want to explore the details and get a quote? Click here: https://hubs.la/Q02BjL-Q0 #iPSCs #Astrocytes #AlzheimersDisease #ParkinsonsDisease #ALS #DrugDiscovery
New product launch: new line, lower price axoCellsTM Astrocytes for better neurodegenerative disease modeling
axolbio.com
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Transcriptional Profiling of iPSC-Derived Microglia for Neurodegenerative Therapy In the seminal study, "Transcriptional Characterization of iPSC-Derived Microglia as a Model for Therapeutic Development in Neurodegeneration," featured in Scientific Reports, authors Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn Akerberg, Bryan Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali AlAbdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfca Sehgal, Alla A. Sigova, Robert T. Fremeau Jr., Yuting Liu, and David Bumcrot deliver a masterful exploration of the potential of iPSC-derived microglia for developing therapies against neurodegenerative diseases. This comprehensive analysis offers groundbreaking insights into the utility of these cells in translational research. Unveiling the Potential of iPSC-Derived Microglia The authors begin by meticulously characterizing iPSC-derived microglia (iMGL) cells, demonstrating their remarkable similarity to primary human microglia. They highlight how iMGL cells express key microglial transcription factors and functional genes, positioning them as a robust in vitro model for neurodegenerative research. This feature singularly positions iMGL cells as a universal tool for studying microglial behavior and therapeutic responses in neurodegeneration. iPSC Microglia: A Paradigm Shift in Neurodegenerative Therapy The study delves deep into the transcriptional profiling of iMGL cells, both at the bulk and single-cell levels. It sheds light on pivotal findings that show iMGL cells exhibit distinct transcriptional subpopulations, representing both homeostatic and activated states similar to those in vivo. The authors meticulously dissect the transcriptional responses of iMGL cells to Liver X Receptor (LXR) pathway agonists, emphasizing their potential in modeling disease states and evaluating therapeutic interventions. Navigating the Therapeutic Landscape Perhaps most compelling is the study's exploration of the clinical relevance of iMGL cells. The authors provide a critical analysis of the cells' transcriptional responsiveness to LXR pathway agonists, demonstrating robust changes in lipid metabolism and cell cycle processes. They advocate for the integration of iMGL cells in drug development pipelines, highlighting their utility in preclinical testing and the potential to uncover novel therapeutic targets. #Neurodegeneration #iPSCCells #Microglia #TherapeuticDevelopment #TranslationalResearch #BiomedicalInnovation #Neurology #CellularTherapy #MedicalResearch #SingleCellSequencing #RNASeq #DiseaseModeling #HealthcareInnovation #Neuroscience #Neuroinflammation #DrugDevelopment #StemCellResearch #GenomicProfiling #LXRPathway #ScientificReports
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📃Scientific paper: Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mTOR in microglia and its importance in Alzheimer's disease (AD) have remained largely uncharacterized. We report that selective loss of Tsc1, a negative regulator of mTOR, in microglia in mice of both sexes, caused mTOR activation and upregulation of Trem2 with enhanced β-Amyloid (Aβ) clearance, reduced spine loss, and improved cognitive function in the 5XFAD AD mouse model. Combined loss of Tsc1 and Trem2 in microglia led to reduced Aβ clearance and increased Aβ plaque burden revealing that Trem2 functions downstream of mTOR. Tsc1 mutant microglia showed increased phagocytosis with upregulation of CD68 and Lamp1 lysosomal proteins. In vitro studies using Tsc1-deficient microglia revealed enhanced endocytosis of the lysosomal tracker indicator Green DND-26 suggesting increased lysosomal activity. Incubation of Tsc1-deficient microglia with fluorescent-labeled Aβ revealed enhanced Aβ uptake and clearance, which was blunted by rapamycin, an mTOR inhibitor. In vivo treatment of mice of relevant genotypes in the 5XFAD background with rapamycin, affected microglial activity, decreased Trem2 expression and reduced Aβ clearance causing an increase in Aβ plaque burden. Prolonged treatment with rapamycin caused even further reduction of mTOR activity, reduction in Trem2 expression, and increase in Aβ levels. ... Continued on ES/IODE ➡️ https://etcse.fr/nSf ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
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#Alzheimer #neuron #signaling #cell Signaling interactions among neurons impact cell fitness and death in Alzheimer’s disease https://lnkd.in/grvTt483 Amit Singh University of Dayton The pathology of Alzheimer’s disease involves a long preclinical period, where the characteristic clinical symptoms of the changes in the brain are undetectable. During the preclinical period, homeostatic mechanisms may help prevent widespread cell death. Evidence has pointed towards selective cell death of diseased neurons playing a potentially protective role. As the disease progresses, dysregulation of signaling pathways that govern cell death contributes to neurodegeneration. Aberrant activation of the c-Jun N-terminal kinase pathway has been established in human and animal models of Alzheimer’s disease caused by amyloid-beta 42- or tau-mediated neurodegeneration. Clonal mosaic studies in Drosophila that examine amyloid-beta 42 in a subset of neurons suggest complex interplay between amyloid-beta 42-expressing and wild-type cells. This review examines the role of c-Jun N-terminal kinase signaling in the context of cell competition and short-range signaling interactions between amyloid-beta 42-expressing and wild-type neurons. Cell competition is a conserved phenomenon regulating tissue integrity by assessing the fitness of cells relative to their neighbors and eliminating suboptimal cells. Somatic clones of amyloid-beta 42 that juxtapose genetically distinct neuronal cell populations show promise for studying neurodegeneration. Generating genetic mosaics with labeled clones of amyloid-beta 42- or tau-expressing and wild-type neurons will allow us to understand how short-range signaling alterations trigger cell death in neurons and thereby contribute to the progression of Alzheimer’s disease. These approaches have the potential to uncover biomarkers for early Alzheimer’s disease detection and new therapeutic targets for intervention.
Signaling interactions among neurons impact cell fitness... : Neural Regeneration Research
journals.lww.com
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Speaking to NeurologyLive, about research in amyotrophic lateral sclerosis (#ALS), Rita Sattler, MSc, PhD, a professor in the Department of Translational Neuroscience at Barrow Neurological Institute said, "There’s not going to be 1 single biomarker that’s going to be the golden ticket for us. We need to understand that we’re probably going to need a combination of biomarkers. And depending on what the clinical trial is being designed as, we may pick one biomarker that sort of measures the overall changes in outcome and progression of the disease as well as another biomarker that would be more of a pharmacodynamic biomarker to see target engagement." Dr. Sattler will provide more insights on translational research in ALS, including the most recent discoveries and utilization of molecular biomarkers for the disease at the 2024 MDA Clinical & Scientific Conference March 3-6 in Orlando, Florida. View the full agenda here: https://lnkd.in/gawc92xD REGISTER: in-person or virtual attendance at MDAconference.org #MDAconference
The Emergence of Novel Biomarkers and Model Systems for ALS: Rita Sattler, MD, MSc
neurologylive.com
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Earliest-yet Alzheimer's biomarker found in mouse model could point to new targets . A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer's disease, report researchers studying a mouse model of the disease. Furthermore, the increased protein activity leads to the seizures associated with the earliest stages of neurodegeneration, and inhibiting the protein in the mice slowed the onset and progression of seizure activity. The neural-specific protein, PSD-95, could pose a new target for Alzheimer's research, early diagnosis and treatment. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers
March 11th 2024
sciencedaily.com
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📃Scientific paper: Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mTOR in microglia and its importance in Alzheimer's disease (AD) have remained largely uncharacterized. We report that selective loss of Tsc1, a negative regulator of mTOR, in microglia in mice of both sexes, caused mTOR activation and upregulation of Trem2 with enhanced β-Amyloid (Aβ) clearance, reduced spine loss, and improved cognitive function in the 5XFAD AD mouse model. Combined loss of Tsc1 and Trem2 in microglia led to reduced Aβ clearance and increased Aβ plaque burden revealing that Trem2 functions downstream of mTOR. Tsc1 mutant microglia showed increased phagocytosis with upregulation of CD68 and Lamp1 lysosomal proteins. In vitro studies using Tsc1-deficient microglia revealed enhanced endocytosis of the lysosomal tracker indicator Green DND-26 suggesting increased lysosomal activity. Incubation of Tsc1-deficient microglia with fluorescent-labeled Aβ revealed enhanced Aβ uptake and clearance, which was blunted by rapamycin, an mTOR inhibitor. In vivo treatment of mice of relevant genotypes in the 5XFAD background with rapamycin, affected microglial activity, decreased Trem2 expression and reduced Aβ clearance causing an increase in Aβ plaque burden. Prolonged treatment with rapamycin caused even further reduction of mTOR activity, reduction in Trem2 expression, and increase in Aβ levels. ... Continued on ES/IODE ➡️ https://etcse.fr/nSf ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
ethicseido.com
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📃Scientific paper: Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mTOR in microglia and its importance in Alzheimer's disease (AD) have remained largely uncharacterized. We report that selective loss of Tsc1, a negative regulator of mTOR, in microglia in mice of both sexes, caused mTOR activation and upregulation of Trem2 with enhanced β-Amyloid (Aβ) clearance, reduced spine loss, and improved cognitive function in the 5XFAD AD mouse model. Combined loss of Tsc1 and Trem2 in microglia led to reduced Aβ clearance and increased Aβ plaque burden revealing that Trem2 functions downstream of mTOR. Tsc1 mutant microglia showed increased phagocytosis with upregulation of CD68 and Lamp1 lysosomal proteins. In vitro studies using Tsc1-deficient microglia revealed enhanced endocytosis of the lysosomal tracker indicator Green DND-26 suggesting increased lysosomal activity. Incubation of Tsc1-deficient microglia with fluorescent-labeled Aβ revealed enhanced Aβ uptake and clearance, which was blunted by rapamycin, an mTOR inhibitor. In vivo treatment of mice of relevant genotypes in the 5XFAD background with rapamycin, affected microglial activity, decreased Trem2 expression and reduced Aβ clearance causing an increase in Aβ plaque burden. Prolonged treatment with rapamycin caused even further reduction of mTOR activity, reduction in Trem2 expression, and increase in Aβ levels. ... Continued on ES/IODE ➡️ https://etcse.fr/nSf ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
ethicseido.com
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Unlocking the mysteries of #ALS requires a multi-faceted approach. Rita Sattler, MD, MSc, Professor of Translational Neuroscience, delves into the latest in translational research and the importance of combining biomarkers for a comprehensive understanding of disease progression ahead of the ALS track she is chairing at the 2024 Muscular Dystrophy Association Clinical & Scientific Conference. Learn more in this NeurologyLive feature and register for the conference today: https://lnkd.in/ggPqES3F #ALSresearch #MDAconference
Speaking to NeurologyLive, about research in amyotrophic lateral sclerosis (#ALS), Rita Sattler, MSc, PhD, a professor in the Department of Translational Neuroscience at Barrow Neurological Institute said, "There’s not going to be 1 single biomarker that’s going to be the golden ticket for us. We need to understand that we’re probably going to need a combination of biomarkers. And depending on what the clinical trial is being designed as, we may pick one biomarker that sort of measures the overall changes in outcome and progression of the disease as well as another biomarker that would be more of a pharmacodynamic biomarker to see target engagement." Dr. Sattler will provide more insights on translational research in ALS, including the most recent discoveries and utilization of molecular biomarkers for the disease at the 2024 MDA Clinical & Scientific Conference March 3-6 in Orlando, Florida. View the full agenda here: https://lnkd.in/gawc92xD REGISTER: in-person or virtual attendance at MDAconference.org #MDAconference
The Emergence of Novel Biomarkers and Model Systems for ALS: Rita Sattler, MD, MSc
neurologylive.com
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