Redefine your CITE-Seq research by expanding its power to intracellular proteins. With our new Intracellular CITE-Seq Assay using BD® AbSeq Antibody-Oligos you can simultaneously detect RNA, surface proteins and intracellular proteins (such as cytokines and transcription factors) to get a full profile of your cells in one experiment like never before. Learn more here: 👉 https://lnkd.in/eUvMfUWT For Research Use Only. Not for use in diagnostic or therapeutic procedures. #IntracellularCITEseq #SingleCellMultiomics #BDRhapsody #BDBiosciences
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Intracellular protein detection from single cells? With whole transcriptome sequencing and cell surface protein detection? And with full length TCR/BCR sequencing? And sample multiplexing? YES, with Rhapsody platform. Maximise single cell data collection from your precious samples. #singlecellanalysis #multiomics #Immunology #CITE-seq
Redefine your CITE-Seq research by expanding its power to intracellular proteins. With our new Intracellular CITE-Seq Assay using BD® AbSeq Antibody-Oligos you can simultaneously detect RNA, surface proteins and intracellular proteins (such as cytokines and transcription factors) to get a full profile of your cells in one experiment like never before. Learn more here: 👉 https://lnkd.in/eUvMfUWT For Research Use Only. Not for use in diagnostic or therapeutic procedures. #IntracellularCITEseq #SingleCellMultiomics #BDRhapsody #BDBiosciences
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An interesting primer from Serna Bio covering developing small molecule binders to RNA targets and how this may differ from protein targets - definitely worth a read. #drugdiscovery #smallmolecule #RNA #nucleicacid #compchem #cheminformatics #machinelearning #artificialintelligence
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💡𝐆𝐞𝐭 𝐦𝐨𝐫𝐞 𝐝𝐚𝐭𝐚 𝐟𝐫𝐨𝐦 𝐲𝐨𝐮𝐫 𝐩𝐫𝐞𝐜𝐢𝐨𝐮𝐬 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐬! Lumit™ immunoassays multiplex effortlessly with cell viability and cytotoxicity assays, enabling you to get 3 data points from a single well. ✔️ Measure cytotoxicity over time using CellTox-Green ✔️ Collect supernatant for Cytokines quantitation using Lumit ✔️ Read cell viability using CellTiter-Glo Not interested in cell viability? Harvest your cells for RNA extraction. 🤓 Read more Lumit : https://bit.ly/48Lj4IG Cell Health : https://bit.ly/48G5Xby RNA Extraction : Manual (https://bit.ly/48HkT9q) or Benchtop automated (https://bit.ly/3uVs5Bc) #ResearchEfficiency #LumitImmunoassays #CellViability #Cytotoxicity #LaboratoryInnovation #labautomation
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"Molecular Biotechnology Senior | Aspiring Molecular Oncologist | Experienced in Cancer Research & Gene Cloning | Unveiling Skills in Communication, Teamwork, and Leadership through Comprehensive Research Expertise"
latest CRISPR news
𝐀𝐧𝐨𝐭𝐡𝐞𝐫 𝐅𝐫𝐢𝐝𝐚𝐲, 𝐚𝐧𝐨𝐭𝐡𝐞𝐫 𝐩𝐚𝐜𝐤𝐞𝐝 𝐧𝐞𝐰𝐬𝐥𝐞𝐭𝐭𝐞𝐫 𝐟𝐫𝐨𝐦 𝐂𝐑𝐈𝐒𝐏𝐑 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐍𝐞𝐰𝐬! ✂ Exciting results from Stephanie Cherqui at UC San Diego and colleagues at Sanford Consortium for Regenerative Medicine, who demonstrate that excision of certain repeats in the FRX gene can rescue disease phenotypes in Friedreich’s ataxia iPSC-derived neurons. ✅ The European Commission approves CASGEVY™ for the treatment of sickle cell disease and beta thalassemia in individuals 12 years and older. 🤝 Intellia Therapeutics, Inc. and ReCode Therapeutics join forces to develop new gene-editing therapies for cystic fibrosis. Get all the news below 👇 https://lnkd.in/ezvnWxHA #crisprmedicinenews #crisprmedicine #geneediting #fda #crispr #raredisease #clinicalnews #crisprnews #crisprtrial Sangamo Therapeutics, Inc. CRISPR Therapeutics Fate Therapeutics Inc Precision BioSciences, Inc. Prime Medicine, Inc.
News: CMN Weekly (16 February 2024) - Your Weekly CRISPR Medicine News - CRISPR Medicine
crisprmedicinenews.com
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Did you know that ABclonal’s Bax Rabbit mAb (A19684) has been cited in over 118 studies and validated for its specificity using Bax knockout (KO) 293T cells? This antibody plays a crucial role in apoptosis and cellular stress research, helping scientists better understand the mechanisms of cell death. If you're investigating apoptosis pathways or studying Bax protein expression, this antibody is a super reliable tool for your experiments. Feel free to explore more about the applications of Bax Rabbit mAb and how it could be useful in your research. https://hubs.li/Q02Rz6V10 #ApoptosisResearch #BaxAntibody #LifeSciences #CellularStress #ScientificResearch #ABclonal #AntibodyValidation #ResearchTools
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Genetic Medicine | RNA Therapeutics | Chemical Development of Oligonucleotide Therapeutics
Interesting read
We’re leading the field of #RNAediting through continuous innovation, including with our growing toolkit of novel chemistries. In our latest publication, we report on our oligonucleotide N-3-uridine (N3U) base modification, which combats the key RNA editing challenge of enzyme sequence bias to expand the scope of therapeutic RNA editing. Read more in NAR Nucleic Acids Research: https://lnkd.in/e8K9ehtU Congratulations to the authors!
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Sometimes, proteins your body makes can cause or contribute to disease. These proteins can be either be faulty, or healthy. RNAi therapeutics are a type of medicine, pioneered by Alnylam, that treats disease by targeting and disabling specific mRNA (messenger RNA) which tell your body how to make these unwanted proteins. #ScienceCurious to learn more about the science of #RNAi? Click here: https://bit.ly/3oR8r2l #RNAiTherapeutics #siRNA #GeneSilencing #science
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Just as Geoff Hale and I have finished drafting a paper comparing Fc variants with enhanced effector function another set gets published. I guess this shows that people still aren't fully satisfied with the existing toolbox of Fc variants and certainly the data we have would suggest there is still room for improvement. These new variants look interesting but why don't people run helpful positive controls in their assays?! In the early screening work the authors compare their variants with a few of the well known variants for enhanced FcgR binding but when it comes to the critical cell killing ADCC assay at the end they just compare to wild type. Surely the key question here isn't are these new variants better than wild type but are they better than the plethora of existing Fc variants for enhanced effector function? We won't know until somebody else goes to the effort of running that assay.
There seems no limit to the number of different Fc variants that antibody engineers are able to produce! A new paper from scientists at The University of Texas Health Science Center at Houston (UTHealth Houston) and University of California, Riverside describes a novel approach to screen Fc variants from CHO libraries to generate variants with improved affinity for FcgRIIa, IIb and IIIa. In particular they focus on a couple of variants that show greatly enhanced ADCC in a PBMC assay. If you are looking to enhance the effector function of your therapeutic antibody this is probably worth a read! DOI: https://lnkd.in/evbpFYkz
Fc engineering by monoclonal mammalian cell display for improved affinity and selectivity towards FcγRs
academic.oup.com
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💡𝐆𝐞𝐭 𝐦𝐨𝐫𝐞 𝐝𝐚𝐭𝐚 𝐟𝐫𝐨𝐦 𝐲𝐨𝐮𝐫 𝐩𝐫𝐞𝐜𝐢𝐨𝐮𝐬 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐬! Lumit™ immunoassays multiplex effortlessly with cell viability and cytotoxicity assays, enabling you to get 3 data points from a single well. ✔️ Measure cytotoxicity over time using CellTox-Green ✔️ Collect supernatant for Cytokines quantitation using Lumit ✔️ Read cell viability using CellTiter-Glo Not interested in cell viability? Harvest your cells for RNA extraction. 🤓 Read more Lumit : https://bit.ly/3wQ5ZjS Cell Health : https://bit.ly/3IIlWf3 RNA Extraction : Manual (https://bit.ly/3uTIztz) or Benchtop automated (https://bit.ly/4c2lDJ7) #ResearchEfficiency #LumitImmunoassays #CellViability #Cytotoxicity #LaboratoryInnovation #labautomation
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Consulting - Projects, Business Ops, Resilience, Audits, Optimization, Crisis Management, Security, Protective Services, Food Security, Training. Spiritual Guidance & Motivation
https://lnkd.in/dQPRvaGV. Coding RNAs generally refers to mRNA that encodes protein ① to act as various components including enzymes, cell structures, and signal transductors. Noncoding RNAs act as cellular regulators without encoding proteins ③.22 May 2019
Coding or Noncoding, the Converging Concepts of RNAs
ncbi.nlm.nih.gov
