BioIVT’s Post

Dissociated tumor cells are a valuable tool in cancer researchers' arsenal. They offer significant advantages for in vitro drug screening and evaluation, personalized medicine applications, and modeling tumor heterogeneity. However, ethical considerations in sourcing starting materials and the limitations of DTCs must be carefully managed. Learn more: https://lnkd.in/ecqNf3Eq #Oncology #Biospecimens #CancerResearch #DrugDevelopment

DTCs provide the closest representation of the clinical scenario containing tumor, epithelial, and immune cells as well as fibroblasts. https://lnkd.in/dcWXcNFd

While no two patients’ tumors are identical, there is a greater likelihood of a therapy being effective if it has been previously tested on dissociated tumor cells (DTCs) from patients with similar health issues. DTCs isolated from freshly resected tumors can be used to determine how specific cohorts of #cancercells will react to different therapies. They can also be incorporated into 3D micro-tumor arrays to provide high-throughput screening and chemo-sensitivity testing. We have ready-to-ship inventory of DTCs, custom procurement capabilities, and extensive expertise in the isolation and propagation of diseased human primary cells. #PBMCs and adjacent normal cellular material are also available for select lots. What does your research program need? https://lnkd.in/eiFmnDqc #Oncology #CancerResearch #DrugDevelopment #biospecimens

Mutation analysis is a valuable #diagnostics tool for many diseases, including cancer, and can support the development of diagnostic assays for specific #biomarkers for patient stratification. We support these efforts through standard mutation analysis for all solid tumors such as lung, colorectal, breast, and head and neck to name a few, as well as custom screening of tissues and biofluids with extraction, library preparation, #sequencing and #bioinformatics services available. If you’ve had difficulty finding the mutation cohort you need, we screen around 600 specimens with NGS data each month! Browse a tailored inventory of our specimens: https://lnkd.in/erEm6-rm Or screen for #mutations: https://lnkd.in/eqZcYTg3

Mutation analysis is a valuable #diagnostics tool for many diseases, including cancer, and can support the development of diagnostic assays for specific #biomarkers for patient stratification. We support these efforts through standard mutation analysis for all solid tumors such as lung, colorectal, breast, and head and neck to name a few, as well as custom screening of tissues and biofluids with extraction, library preparation, #sequencing and #bioinformatics services available. If you’ve had difficulty finding the mutation cohort you need, we screen around 600 specimens with NGS data each month! Browse a tailored inventory of our specimens: https://lnkd.in/eBcxCJfN Or screen for #mutations: https://lnkd.in/eC6iNuEP

While cells can be manually isolated in-house, the process requires expertise, bandwidth &/or capacity that many researchers do not have available. We can fill that gap so you can focus on your research. Our extensive #biospecimens portfolio includes readily-available, high-quality, fresh and cryopreserved cells from a diverse range of highly characterized donors, including immune cells and purified subsets such as: Lymphocytes - CD3+, CD4+, and CD8+ #Tcells - CD56+ NK cells - CD19+, CD20+ B cells Monocytes and Granulocytes: - CD14+ - Basophils, Eosinophils, Neutrophils Stem Cells: - CD34+ View the full options and learn more: https://lnkd.in/eNK9rp37

Did you miss our #scientificposter, "Using siRNA Generated Isogenic Pairs in a Micropatterned Primary #Hepatocytes Co-culture (#HEPATOPAC) to Define the Role of CIDEB in a Model of Hepatic Steatosis," at the MASH & Fibrosis Symposia last month? No problem! It’s now available on our website: https://lnkd.in/dbGwNeaH Therapeutic development for metabolic dysfunction-associated fatty liver disease (#MAFLD) treatment is focused on identifying and validating novel targets for disease modulation, including genetic variants which modulate individuals’ risk to develop MAFLD. A recent study identified loss-of-function variants in cell death-inducing DFFA like effector B (CIDEB) which provide a protective effect for risk of #liverdisease. We explored the role of CIDEB in hepatic steatosis using our long-term primary hepatocyte culture model. View poster: https://lnkd.in/dbGwNeaH

The #scientificposter we presented at the #MicrophysiologicalSystems World Summit last month is now available. It demonstrates the utility of #HEPATOPAC for generating #siRNA mediated isogenic pairs for both #ADME and target screening applications. siRNA knockdown can be utilized to explore ADME-Tox related gene function in a well differentiated #hepatocyte model. Gene Knockdown in HEPATOPAC can be used to assess the effects of gene function on disease state modeling such as #MASLD and validate potential therapeutic modalities. #GalNAc conjugated siRNA can be utilized in the HEPATOPAC model and uptake and knockdown from these treatments is #ASGPR expression dependent. View the poster: https://hubs.ly/Q02GFHn00

Here is Labiotech.eu’s weekly roundup of the latest #biotech news.

How to generate high-quality, monoclonal cell populations in cell line development (CLD)? 🌟 If you're a scientist facing challenges with precise single-cell seeding, boosting cell line purity, scalability, or isolating rare cells, read this blog by Dr. Katrin Raute, PhD for success strategies that also help with regulatory compliance. 💡 Inside the Blog: ✔️ Importance of single-cell seeding ✔️ Methods to ensure traceability and regulatory compliance ✔️ Isolation of rare cells in oncology and microbiome research ✔️ Verifying cell viability and purity … and more. Access the full article now. 📖👇 https://lnkd.in/eF2iA9a4 #CellLineDevelopment #SingleCellSeeding #HealthCareInnovation #Biotech #Blog