BiOkuris’ Post

Delving into unmet medical needs in IBS and highlighting our patented technology's ability to address multiple pathways in IBS pathophysiology marks a pivotal stride in our innovation journey. Gratitude to all involved in this research and the creation of this insightful article!

📢 The Gut-Kidney Connection 📰 Thanks Majd Isreb, MD, FACP, FASN, IFMCP and Integrative Kidney Institute for sharing thus interesting study! Short Chain Fatty Acids (SCFA) like Propionate and Butyrate are a function of healthy/balanced gut bacteria. The levels of SCFA produced by the microbiome affect gut health and can contribute to the development of several diseases 👉🏽 including kidney disease. The study demonstrated that: 1️⃣ levels of propionate and butyrate in stool were lower in CKD patients and gradually reduced as the disease progresse 2️⃣ "Early administration of these SCFAs prevents disease advancement in a pre-clinical model of acute renal damage, demonstrating their therapeutic potential independently of the gut microbiota." ✨️ This is a major step in better understanding the role of applying an Integrative lense in renal care by supporting gut health and mucrobiome balance as a foundation in protecting kidney health. Read the full article here: https://lnkd.in/euYXKQvv ❇️ From your experience, what do you think of this study or the gut-kidney connection? #kidneydisease #pharmacist #integrativemedicine #nephrology #microbiome

Finally his colon starts to fire properly! A middle age men who was lived abroad, visited me at OPD. He has been suffering from constipation for long. Previously multiple investigations were done and fatigued being investigated and gave me a bulk of investigation files. I told him I have to look at the investigation in details and took the file home. After over night review of his investigation files, including colonoscopy results and pelvic floor dysfunction workups, he fulfilled the Rome IV criteria as having functional constipation (FC). On the next day he came and we discussed about his case. I told him “his colon is not firing properly” likely because of gut desbiosis. Prescribed him probiotics ( which contains Lactobacillus)for 3months. After three months he came….He was smiling and he said “Finally my colon starts firing” we both laughed…what a relief. Key messages: chronic idiopathic constipation with normal transit, further subclassified as functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C) with significant overlap. There is an increasing body of evidence that alteration of gut microbiota may contribute to the development of functional bowel disorders, which may be secondary to gut microbiota dysbiosis responsible for altered metabolic activity. NB: probiotics use for functional constipation, the large heterogeneity of the studies included in the systematic reviews, as well as in meta-analyses (e.g. numbers of samples, ethnicity, methodology), makes it difficult to establish a consensus or guidelines. Segenet Bizuneh #UoGSCH #InternalMedicine #GIclinic

A new study in Diabetology & Metabolic Syndrome has investigated the link between metabolic syndrome and the risk of developing primary open-angle glaucoma, a condition characterized by the gradual loss of retinal ganglion cells and optic nerve degeneration, eventually leading to irreversible vision loss. Analyzing data from the 2019-2021 Korean National Health and Nutrition Examination Survey, encompassing 11,499 adults aged 19 years and above, the researchers categorized participants into groups based on the presence or absence of metabolic syndrome. Findings revealed a notable dose-response relationship between the number of metabolic syndrome components a person had and their risk of developing primary open-angle glaucoma. Consequently, the study suggests that people with metabolic syndrome, who are at a heightened risk of primary open-angle glaucoma, especially normal-tension glaucoma, should undergo comprehensive ophthalmological evaluations as a preventive measure. — Lee, JH., Kwon, YJ., Kim, S.J. et al. Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study. Diabetol Metab Syndr 15, 177 (2023). 📌 Link to study: https://lnkd.in/g2G3Nevg 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #Ketogenicdiet #Nutritionaltherapy #Research

¿Ya lo conoce? #SaludMetabólica #HafniaAlvei #ProbioSatys #Obesidad 1. Gut microbiota and obesity: role in aetiology and potential therapeutic target. Carthage Moran  31 Jul 2014-Best Practice & Research in Clinical Gastroenterology 2. Gut microbiota in obesity Bing-Nan Liu  06 Jul 2021-World Journal of Gastroenterology 3. Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity. Nicolas Lucas  22 Dec 2019 4. The Probiotic Strain H. alvei HA4597 ® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study. Pierre Déchelotte  31 May 2021-Nutrients 5. 5. An overview of microbiome based strategies on anti-obesity. Cherng Shyang Chang  31 Dec 2018-Kaohsiung Journal of Medical Sciences

#TrendingWithImpact: On March 3, 2024, researchers from Pusan National University published a new research paper in Aging's Volume 16, Issue 5, entitled, “FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.” “This discovery unveils a potential novel molecular target for therapeutic strategies against hepatic steatosis during the aging process [...]” #PressRelease: https://lnkd.in/e4nr7Gyi #aging #hyperlipidemia #steatosis #diet #agingresearch #openaccess #openscience #peerreviewed #journal #publication #publishing #meded

Effects of maternal PFAS exposure and high-fat diet on hepatic proteome and metabolic health in mouse offspring: experimental insights and human implications Proteomic analysis of the livers of offspring of pregnant mice exposed to PFOA, PFOS, PFHxS, or their mixture in combination with a high-fat diet revealed that PFAS exposure affected biochemical pathways associated with liver injury, xenobiotic metabolism, and lipid regulation. These changes suggest that maternal exposure to PFAS may predispose offspring to hepatic and metabolic dysfunction. https://lnkd.in/dnRTXGeA However, caution must be exercised in interpreting the results and we must keep in mind that: i) The mice were exposed to very high levels of PFAS; ii) Mice are much more susceptible than humans to liver damage caused by PFAS due to binding to their PPARalpha receptor; iii) Such a high-fat diet is not common in the general human population. Therefore, these results, although of experimental interest, cannot be extrapolated to humans. #pfas #foreverchemicals #cleanwaters #bioremediation #enzymes

Keen to hear your thoughts… Sarcopenia vs myopenia terminology when it comes to nutrition research describing skeletal muscle loss in clinical conditions. Let’s first look at the definitions. Sarcopenia is defined as an age-related loss in skeletal muscle mass and function. Myopenia is described as the presence of clinically relevant muscle wasting due to illness at any age. I’ve noticed recently, in the last few years, an increasing number of clinical nutrition research is using sarcopenia as the definition for skeletal muscle loss. Particularly in critical illness. Given the definition above, is this the correct and or most accurate use of the term sarcopenia? I don’t think so. Why do you ask? Well, what terminology do you use for younger patients? What about muscle wasting due to, immobility, cancer, chronic heart failure, lung and kidney diseases? All these conditions can occur at any age. While it’s great to see more research being done in this space to highlight the importance of the negative clinical and functional effects that muscle wasting has on patients in hospital, using the term sarcopenia may be confusing both scientific and medical communities. Instead, I believe the term myopenia may be a better definition. This terminology can encompass a large range of disease related levels of muscle loss, including sarcopenia. Let me know your thoughts in the comments below. Open to a constructive discussion around this topic. For more, see this editorial by Fearon, et al (2011). PMC3063883. Image Source: Fearon et al (2011) #terminology #myopenia #sarcopenia #criticalillness #yourthoughts Note: These opinions are my own, and are not the opinions of the companies I work for or have worked for in the past.

Please register for Hifas da Terra’s next educational webinar ’A Deep Dive into Mycotherapy in Clinical Practice’ Presented by Naturopathic Nutritionist, Tanya Clarke 14th May 2024 - 7:00 PM Do you have a yearning to use mycotherapy with more clients? Are you confused as to how different medicinal mushroom concentrations and formulas can be applied in individual and complex cases? If so, this webinar is for you. Join experienced Mycotherapist Tanya Clarke for an in-depth review of six of her clinical cases. Together we will journey through these detailed case studies and how you might consider applying Hifas da Terra medicinal mushroom formulas for a variety of conditions, ranging from chronic fatigue, eczema, cancer, candida and grief. Through Tanya’s observations you will learn how functional mushrooms and certain strains and combinations can be suitably dosed at different stages of an individual’s quest for health, in order to balance and calm the immune system and ultimately restore emotional equilibrium and vitality. Please click the link to register your spot: https://lnkd.in/epipiZwV