Keto-Mojo

The evidence shows that patients who receive instant feedback on their dietary choices have higher rates of compliance. That's why real-time monitoring of patient health data can be a game-changer for health practitioners who, in the past, have had to rely on the memory and honesty of patients in reporting compliance with their treatment programs. With MyMojoHealth, practitioners can quickly scan their patient's blood glucose and ketone readings on a daily or weekly basis and identify the patients that need more attention. Learn more about the free MyMojoHealth platform for healthcare practitioners here: https://lnkd.in/ghUcjDcT #keto #ketomojo #healthcare #remotepatientmonitoring https://lnkd.in/gVNr-3CK

Fasting takes the spotlight this week! 🌟 In this special edition of our Spotlight on Keto Research, we’ve gathered the latest science on time-restricted eating and intermittent fasting and their powerful impact on metabolic health. Curious about the science of fasting? Check out this week’s newsletter and subscribe for more keto science every week! 🔍 #MetabolicHealth #IntermittentFasting #TimeRestrictedEating

Multiple sclerosis (MS) is a neurodegenerative disease that can cause various symptoms, including sleep disturbances, which affect up to 50% of individuals with the condition. These disturbances––such as insomnia, obstructive sleep apnea, and restless leg syndrome–– significantly impact quality of life and contribute to fatigue in people with MS. Sleep disturbances are also linked to metabolic, vascular, and immune dysfunction. Researchers are investigating ketogenic diets in people with MS because of their potential benefits for reducing inflammation and improving metabolic health. Growing evidence suggests that KDs can also enhance sleep quality. A six-month trial evaluated the effects of a ketogenic modified Atkins diet on sleep disorder symptoms in 65 patients with relapsing multiple sclerosis (MS). Net carbohydrate intake was limited to less than 20 grams per day, and adherence to the intervention was monitored through daily urine ketone tests. Sleep disorder symptoms were assessed at baseline and after 6 months. Statistical analyses were conducted to evaluate changes in sleep quality, sleep disorder symptoms, and their correlation with fatigue, depression, and quality of life. 87% of participants completed both baseline and 6-month assessments. Results: 🔷 Excessive daytime sleepiness (EDS): The mean ESS score decreased by 1.9 points, with the percentage of participants experiencing EDS dropping from 15.4% to 7.7%. 🔷 Sleep disorder symptoms: → Insomnia scores reduced by 1.55 points. → Obstructive sleep apnea (OSA) scores dropped by 0.91 points. → Restless leg syndrome (RLS) scores decreased by 1.00 points. 🔷 Sleep diaries: There was a slight reduction in wake after sleep onset at 3 months but no significant change at 6 months. 🔷 Correlations: Improvements in daytime sleepiness correlated with reductions in fatigue, depression, and improved quality of life. In this trial, a ketogenic diet improved daytime sleepiness and reduced symptoms of insomnia, OSA, and RLS in people with relapsing MS. These improvements were independent of changes in sleep duration. These findings suggest that a ketogenic diet could be a valuable adjunct treatment for improving sleep in people with MS. — Perlman J, Wetmore E, Lehner-Gulotta D, Banwell B, Bergqvist C, Coleman R, Chen S, Conaway M, Goldman MD, Morse AM, Brenton N. Impact of a ketogenic diet on sleep quality in people with relapsing multiple sclerosis. Sleep Med. 2024. Oct:122:213-220. doi: 10.1016/j.sleep.2024.08.020 📌 Link to study: https://lnkd.in/gdamTxQu 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #KetoDiet #MultipleSclerosis #Research

Could Ketones Help Us Age Better? A recent editorial by Cadar & Bartley in The Journal of Nutrition, Health and Aging highlights the potential of ketones to support healthy aging by slowing down declines in essential biological processes. Typically, ketones are produced while on a ketogenic diet (low carb, high fat, moderate protein) and serve as an alternative energy source to glucose. For those not following a ketogenic diet, ketone supplements offer an effective way to boost ketone levels. Research suggests that ketones may have unique signaling properties that promote muscle preservation, cognitive function, inflammation reduction, cancer prevention, and improved mitochondrial and metabolic function. Ketones could be a key to extending our health span. Exciting research is underway! --- Cadar & Bartley. The sweet escape: Are ketones a key player in unlocking healthy aging? The Journal of nutrition, health and aging 28 (2024) 100395. https://lnkd.in/g9KXQ-mZ #Keto #KetoDiet #Research #Longevity #HealthyAging #MetabolicHealth

In recognition of National Diabetes Month, we’re sharing a new article that delves into the science, addresses common safety concerns, and provides practical tips and resources for managing type 1 diabetes with a ketogenic or very low-carb diet. Read the full article: https://lnkd.in/gHQrdvWN

Intermittent fasting (IF) and time-restricted feeding (TRF) are dietary regimens known to produce favorable metabolic outcomes. During periods of fasting, ketones are well-recognized as an essential fuel for the brain, while their role in skeletal muscle and heart has been explored less. This study investigated muscle ketone metabolism in mice during a newly developed intermittent TRF (iTRF) schedule, consisting of 4 days of 18-hour fasting (to drive a strong ketogenic response) followed by 3 days of unrestricted feeding (to allow recovery). Mitochondria in heart and skeletal muscles are highly efficient at fatty acid oxidation (FAO) and contain high amounts of the enzyme beta-hydroxybutyrate dehydrogenase 1 (BDH1). This study used mice with a deficiency of BDH1 in their striated muscles to understand the enzyme's role. Key findings: 🔷 Muscle remodeling and ketone flux: The benefits of iTRF on muscle remodeling were closely linked to ketone flux via BDH1, particularly in the heart and oxidative skeletal muscle. 🔷 Fat oxidation and exercise tolerance: Mice deficient in BDH1 showed impaired fat oxidation and reduced exercise tolerance during fasting, indicating that BDH1 is critical for efficient mitochondrial function in muscle. 🔷 Metabolic benefits of iTRF: iTRF led to significant muscle remodeling, such as increased lean mass and enhanced mitochondrial bioenergetics, but these benefits were diminished in BDH1-deficient mice. Conclusions: These findings provide new insights into the importance of ketones in skeletal and cardiac muscle metabolism. Understanding these mechanisms deepens our knowledge of how fasting promotes muscle remodeling, enhances mitochondrial efficiency, and optimizes energy utilization. These insights have potential applications in developing therapeutic strategies to improve metabolic health and muscle function. — Williams AS, Crown SB, Lyons SP, et al. Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding. Cell Metabolism 2024;36:422–437 📌 Link to study: 10.1016/j.cmet.2024.01.007 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #KetoDiet #Research

In this study, researchers investigated the potential protective effects of a medium-chain triglyceride ketogenic diet in a mouse model of Parkinson's disease. They looked at the damage to specific brain cells, the gut bacteria, and the substances produced by the gut bacteria. The results showed that a long-term ketogenic diet significantly reduced damage to dopamine-producing neurons in the brain, which are affected in Parkinson's disease. The ketogenic diet also had antioxidant effects and reduced oxidative stress in the neurons. It protected the mitochondria and inhibited the activation of microglia, immune cells in the brain. Additionally, the ketogenic diet altered the composition of gut bacteria and the metabolites they produce, which influenced the metabolism of neurons in the brain region affected by Parkinson's disease. Overall, the study suggests that the medium-chain triglyceride ketogenic diet has multiple protective effects against Parkinson's disease. — Zhang W, Chen S, Huang X, Tong H, Niu H, Lu L. Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: a combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome. Cell Death Discov. 2023 Jul 17;9(1):251. doi: 10.1038/s41420-023-01549-0. PMID: 37460539; PMCID: PMC10352270. 📌 Link to study: https://lnkd.in/g9j8THqe 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Parkinsons #keto #ketogenicdiet #nutritionaltherapy #research

📢 The latest Spotlight on Keto Research is packed with insights on the applications of ketogenic therapies. 🔬Interested in how keto could impact genetic kidney disease? Fatty liver? Inflammatory bowel disease? Cognitive health? Or even aging and cancer progression? It's all in this issue! 📚 Check it out now and subscribe to stay updated on the latest in keto science! #MetabolicHealth #KetogenicTherapies

In a recent article in Nature Communications, the authors explore the complexity of metabolic reprogramming in ErbB2+ breast cancer models, in vitro and in vivo. While the Warburg effect shows increased glucose consumption in tumors, recent research shows that HER2+ breast cancer cells can rewire lipid metabolism to fuel their growth and resist treatments. Carnitine palmitoyl transferase 1a (Cpt1a) is a key enzyme involved in the mitochondrial uptake and oxidation of long-chain fatty acids, with a crucial role in fatty acid metabolism. In ErbB2+ breast cancer models, removing Cpt1a reduced tumor growth and metastasis. However, these cells also became more dependent on glucose, which helped them survive and grow. In this study the combination of Cpt1a inhibition with either a ketogenic diet (high in long-chain fatty acids) or treatment with anti-HER2 monoclonal antibodies significantly affected tumor growth, enhanced apoptosis, and reduced lung metastasis. These findings offer a new potential therapeutic approach to combat resistance in HER2+ breast cancer. — Nandi I., Ji L., Smith HW., Avizonis D., Papavasiliou V., Lavoie C., Pacis A., Attalla S., Sanguin-Gendreau V. & J. Muller WJ. Targeting fatty acid oxidation enhances response to HER2-targeted therapy. Nat Commun. 2024;15(1):6587. doi: 10.1038/s41467-024-50998-3 📌 Link to study: https://lnkd.in/g7yw6ehH 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #Ketogenicdiet #Nutritionaltherapy #Research #BreastCancerAwareness #HER2Positive #CancerResearch

While insulin therapy has dramatically improved life expectancy for people with type 1 diabetes (T1D), blood sugar control remains challenging. For this reason, there has been growing interest in low-carbohydrate diets for improving blood glucose levels and reducing insulin requirements. A case report detailed the experience of a 37-year-old man newly diagnosed with T1DM who adopted a low-carbohydrate diet shortly after diagnosis. Although he had rapid improvements in blood glucose levels and HbA1c after starting insulin therapy, he was concerned about glycemic variability and hypoglycemia. After doing his own research, he began following a low-carb diet of 85–100 grams of carbohydrates per day, which he gradually reduced to around 15 grams per day. Results: 🔷HbA1c improved from 11.6% at diagnosis to 6.2% within 11 months of starting the low-carb diet. 🔷Insulin requirements were minimized. The patient achieved temporary insulin-free remission for over a year. His current dose is approximately 2 units of rapid-acting insulin daily, 6.5 years post-diagnosis. 🔷Blood glucose levels have been well-controlled with minimal variability, and no hypoglycemic episodes were reported. 🔷Beta-hydroxybutyrate concentrations, indicating ketosis, have remained at safe and stable levels between 0.3 and 1.2 mmol/L. This case report suggests that very-low-carbohydrate diets may extend the "honeymoon period" of T1DM and lead to stable blood glucose control with low insulin requirements after temporary remission ends. However, the researchers state that further studies are needed to understand long-term safety and outcomes. — Ozoran H, Guwa P, Dyson P, Tan GD, Karpe F. Prolonged remission followed by low insulin requirements in a patient with type 1 diabetes on a very low-carbohydrate diet. Endocrinology, Diabetes, and Metabolism Case Reports. 2024 Jan 1; 2024(1): 23-0130. doi: 10.1530/EDM-23-0130 📌 Link to study: https://lnkd.in/gfAg8_FQ 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #lowcarb #type1diabetes #Research